Systematic ReviewSentinel lymph node assessment in endometrial cancer: a systematic review and meta-analysis
Section snippets
Search strategy
We searched Medline, Embase, and the Cochrane Library from database inception to March 25, 2016. Electronic searches were supplemented by reviewing reference lists of included studies and prior systematic reviews, hand-searching the journal Gynecologic Oncology, and contacting the authors of included studies for any additional published or unpublished studies meeting review inclusion criteria. When the search strategy identified a meeting abstract, we searched Medline for an associated
Results
Of the 1230 abstracts screened, 55 articles including 4915 women with endometrial cancer were eligible for inclusion (Figure 1).11, 12, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66 The kappa statistic for interrater reliability was 96%. Twenty-one studies were conducted in North America, 23 in Europe, 6 in the Middle East, 3 in Asia, and 2 in
Comment
In this systematic review and meta-analysis of 55 studies including 4915 women investigating the utility of SLN mapping for endometrial cancer, the following 3 primary findings emerged: (1) the pooled overall SLN detection rates were relatively high at 81% (95% CI, 77–84) with 51% (95% CI, 45–54) bilateral nodal detection; (2) the pooled sensitivity of SLN mapping for the detection of lymphatic metastases was high at 96% (95% CI, 92–98); (3) and the use of cervical injection with combination
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The authors report no conflict of interest.