Original articleA Comparison of Vitamin A and Cyclosporine A 0.05% Eye Drops for Treatment of Dry Eye Syndrome
Section snippets
Methods
Eligible patients were at least 21 years of age and had a diagnosis of dry eye syndrome refractory to conventional management. The inclusion criteria were: Schirmer test (without anesthesia) results of less than 5 mm/5 minutes in at least one eye; low tear film BUT (<5 seconds); mild superficial punctate keratitis, defined as a corneal punctate fluorescein staining score of one or more in either eye (scale, 0 [none] to 3 [severe]); and symptoms of ocular irritation as assessed by an Ocular
Results
The characteristics of the study patients are presented in Table 1. There were no statistically significant differences in age, gender, or pretreatment tear film or ocular surface parameters among the three patient groups. A total of 150 patients were enrolled in equal numbers across the three treatment groups. The first patient was enrolled in July 2006, and the last patient completed the three-month treatment and evaluation in February 2007.
There was no statistically significant difference
Discussion
The vitamin A eye drops used in our study are preservative free and are composed of polysorbate 80 1% and retinyl palmitate 0.05%. Vitamin A is known to regulate the proliferation and differentiation of corneal epithelial cells, preserves conjunctival goblet cells,8 and has been used in the treatment of eye diseases such as dry eye and superior limbic keratoconjunctivitis for some time.12, 18, 19, 20, 21, 22 Tseng demonstrated that topical all-trans retinoic acid ointment was effective in the
Eun Chul Kim, MD, is a Assistant Professor of the Department of Ophthalmology and Visual Science at the College of Medicine, Catholic University of Korea, Seoul, Korea. He completed a residency and a fellowship at the, KangNam St Mary's Hospital, Seoul, Korea. Dr Kim specializes in cornea, cataract, and refractive surgery, and his research interests include keratoplasty and dry eye syndrome.
References (25)
- et al.
Efficacy and safety of cyclosporine ophthalmic emulsion in the treatment of moderate-to-severe dry eye disease: a dose-ranging, randomized trial
Ophthalmology
(2000) - et al.
Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease
Ophthalmology
(2000) - et al.
Possible mechanisms for the loss of goblet cells in mucin-deficient disorders
Ophthalmology
(1984) Staging of conjunctival squamous metaplasia by impression cytology
Ophthalmology
(1985)- et al.
Vitamin A eye drops for superior limbic keratoconjunctivitis
Am J Ophthalmol
(1988) - et al.
Topical retinoid treatment for various dry eye disorders
Ophthalmology
(1989) Scientific basis for medical therapy of cataracts by antioxidants
Am J Clin Nutr
(1991)Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes
CLAO J
(1995)- et al.
Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation
Cornea
(1998) Inflammation: a unifying theory for the origin of dry eye syndrome
Manag Care
(2003)
Cellulose acetate impressions of the ocular surfaceDry eye states
Arch Ophthalmol
Effect of retinol palmitate as a treatment for dry eye: a cytological evaluation
Ophthalmologica
Cited by (0)
Eun Chul Kim, MD, is a Assistant Professor of the Department of Ophthalmology and Visual Science at the College of Medicine, Catholic University of Korea, Seoul, Korea. He completed a residency and a fellowship at the, KangNam St Mary's Hospital, Seoul, Korea. Dr Kim specializes in cornea, cataract, and refractive surgery, and his research interests include keratoplasty and dry eye syndrome.
Supplemental Material available at AJO.com.