Reflection and ReactionTrials comparing cytology with human papillomavirus screening
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Options for triage and implications for colposcopists within European HPV-based cervical screening programmes
2021, European Journal of Obstetrics and Gynecology and Reproductive BiologyEuropean Code against Cancer, 4th Edition: Cancer screening
2015, Cancer EpidemiologyCitation Excerpt :Cytology screening in women younger than 25 years has lower detection rates, higher false-positive rates, and lower effectiveness than in older women [146] (level of evidence: III–IV). HPV testing is more sensitive than cytology [147,148]. HPV testing was substantially more sensitive in detecting CIN2+ than cytology (96.1% versus 53.0%) but less specific (90.7% versus 96.3%).
Advances in colposcopy: New technologies to challenge current practice
2014, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :In a meta-analysis of 25 studies Koliopoulos et al. (2007) reported a combined sensitivity of hybrid capture II HPV testing to detect CIN2+ of 90% compared to cytology (threshold of atypical squamous cells of undetermined significance: ASC-US) of 73% [12]. More colposcopies would be anticipated with an HPV-based screening test positive rate of up to 16% [13–16] with an approximate doubling of the referral rate to colposcopy compared to that for current cytology-based screening [17]. A post implementation report of HPV-based screening in Italy revealed 11% (31/272) of colposcopy referrals yielded a diagnosis of CIN2+ following triage with ASC-US or worse cytology [18].
Cervical cancer screening: on the way to a shift from cytology to full molecular screening
2014, Annals of OncologyCervical Cytology (The Pap Test)
2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms