REVIEW ARTICLE
Measurement of Quality of Life in Pediatric Asthma Clinical Trials

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Objective

This review will provide the reader a current appraisal of attempts to measure quality of life (QoL) in pediatric asthma and guidelines toward making a discriminating selection from available QoL questionnaires.

Data sources

A MEDLINE literature search was performed using the index terms quality of life and asthma. Reference lists from articles identified through this search were also perused. References that did not include the term “quality of life” but clearly addressed this topic were included.

Results

Nine questionnaires employed in studies evaluating life quality associated with pediatric asthma were identified. Five of the questionnaires are parent-completed and four are child-completed. The instruments vary considerably in length and content areas, and most have been used in a single study.

Conclusion

The science of measuring QoL change associated with pediatric asthma is in its infancy and the decision to use any single QoL instrument should be made cautiously. Investigators seeking to employ a QoL questionnaire in pediatric asthma clinical trials must consider several problems specific to evaluation with children, including age effects, reading ability, impact of adult assistance upon responses, and the inclusion of mother-versus father-completed questionnaires. The selected QoL questionnaire should address specific hypotheses and be piloted by the investigator before inclusion in a planned investigation.

References (23)

  • BG Bender et al.

    Neuropsychiatric effects of medications for allergic diseases

    J Allergy Clin Immunol

    (1995)
  • EF Juniper et al.

    Determining a minimal important change in a disease-specific quality of life instrument

    J Clin Epidemiol

    (1994)
  • GA Fava

    Methodological and conceptual issues in research on quality of life

    Psychother Psychosom

    (1990)
  • H Schipper et al.

    Quality of life studies: definitions and conceptual issues.

  • AE Kazdin

    Research design in clinical psychology

    (1992)
  • EF Juniper et al.

    Measuring quality of life in children with asthma

    Qual Life Res

    (1996)
  • AJ McSweeney et al.

    Health-related quality-of-life assessment in medical care

    Dis Month

    (1995)
  • S Harter et al.

    Developmental changes in children's understanding of single, multiple, and blended emotion concepts.

  • TL Creer et al.

    A life activities questionnaire for childhood asthma

    J Asthma

    (1993)
  • MJ Christie et al.

    The patients' perceptions of chronic disease and its management: psychosomatics, holism and quality of life in contemporary management of childhood asthma

    Psychother Psychosom

    (1991)
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    Supported by a grant from Zeneca Pharmaceuticals

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