Original ArticleMechanisms of post-traumatic seizures: a quantum pharmacological analysis of the molecular properties of an epileptogenic focus following iron-induced membrane peroxidation
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Cited by (10)
Post-traumatic seizures-A prospective, multicenter, large case study after head injury in China
2013, Epilepsy ResearchCitation Excerpt :However, the mechanisms of PTS caused by contusion are still not clear. According to former studies (Willmore et al., 1978; Dakin and Weaver, 1993; Angeleri et al., 1999; Kharatishvili et al., 2006; Sharma et al., 2007), a possible explanation for this may be the following: cortical neurons injured following contusions, and this would lead the iron from the blood deposited in the cortex; the deposited iron would lead to iron-induced membrane peroxidation, and would make the seizure spread to the subcortical areas (hippocampus mainly); the occurrence and evolution of the epileptiform activity in the subcortical structures would in parallel with that in the cortical focus. Further studies are needed to unveil this topic.
Trace elements and electrolytes homeostasis and their relation to antioxidant enzyme activity in brain hyperexcitability of epileptic patients
2004, Journal of Pharmacological SciencesEnhanced lipid peroxidation in epileptics with null genotype of glutathione S-transferase M1 and intractable seizure
2002, Japanese Journal of PharmacologyA prospective study to determine the risk factors associated with post traumatic seizures: A single institution experience
2023, Surgical Neurology InternationalThe effects of vigabatrin on rat liver antioxidant status
2005, Drug Metabolism and Drug InteractionsThe effects of oxcarbazepine on oxidative stress in epileptic patients
2004, Methods and Findings in Experimental and Clinical Pharmacology
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