Medicine; pathology
Peripheral giant cell granuloma. Clinicopathologic study of 224 new cases and review of 956 reported cases

https://doi.org/10.1016/S0901-5027(88)80158-9Get rights and content

Abstract

The clinical and histopathological features of 224 new cases of peripheral giant cell granuloma were studied. In addition, the data from 956 previously reported cases in the literature were evaluated and compared with the present series. Females were found to be more commonly affected than males. All age groups were found to be affected with a relative predilection from 40 to 60 years of age. The mandible was more often affected than the maxilla. Clinically, the lesions were red in color, had a smooth surface and were rubbery or with a soft consistency. The most characteristic histologic features included a non-encapsulated highly cellular mass with abundant giant cells, inflammation, interstitial hemorrhage, hemosiderin deposits, mature bone or osteoid.

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    Citation Excerpt :

    PGCG tends to occur more frequently between the ages of 40 and 60, more frequently in women and in the mandible rather than the maxilla (Dojcinovic, Richter, & Lombardi, 2010). Although its etiology is not fully understood, it is thought to be associated with irritant and traumatic factors on the basis of poor oral hygiene (Katsikeris, Kakarantza-Angelopoulou, & Angelopoulos, 1988). In the microscopic examination of PGCGs, fibroblastic spindle mesenchymal cells and osteoclast-like multinuclear giant cells are seen.

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