Attenuation of amphetamine-stereotypy by mesostriatal dopamine depletion enhances plasma corticosterone: Implications for stereotypy as a coping response

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The relationship between amphetamine-induced stereotyped behavior and a neuroendocrine index of arousal, plasma corticosterone (CCS), was investigated. 6-Hydroxydopamine lesions of the caudate-putamen, which produced dopamine depletions of 60%, blocked stereotypy and prolonged the elevation in corticosterone associated with d-amphetamine treatment (5 mg/kg). Similar dopamine depleting lesions of the nucleus accumbens, which attenuated the locomotor, but not the stereotypic, response to AMPH did not have this effect on CCS. This pattern of results supports the hypothesis that stereotypy has a coping function which may serve to alter arousal and further suggests important differences between the nigrostriatal and mesolimbic dopamine projections in modulating the responsiveness of the neuroendocrine system. These results have implications for understanding the function of behavioral stereotypies common to a number of psychopathological conditions, including schizophrenia and childhood autism.

References (34)

  • AngristB. et al.

    The phenomenology of experimentally induced amphetamine psychosis: Preliminary observations

    Biological Psychiatry

    (1970)
  • AntelmanS.M. et al.

    Amphetamine as a stressor

  • BlancG. et al.

    Response to stress of mesocortico-frontal dopaminergic neurones in rats after longterm isolation

    Nature (London)

    (1980)
  • BleulerE.P.

    Dementia praecox or the group of schizophrenics

    (1950)
  • BreeseG.R. et al.

    Depletion of brain noradrenaline and dopamine by 6-hydoxydopamine

    British Journal of Pharmacology

    (1971)
  • ConnellP.H.

    Amphetamine psychosis

    (1958)
  • CorbettJ.A. et al.

    Tics and Gilles de la Tourette's syndrome: A follow-up study and critical review

    British Journal of Psychiatry

    (1969)
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    G.M. was supported by a postdoctoral fellowship and NSF Grant INT-8402257.

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