Letters to the EditorCerebellar hypoplasia and hyperplasia in infantile autism
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Cited by (66)
Antiepileptic drugs lamotrigine and valproate differentially affect neuronal maturation in the developing chick embryo, yet with PAX6 as a potential common mediator
2022, Neurotoxicology and TeratologyCitation Excerpt :These effects were rapid and occurred within 24 h after drug administration. Cerebellar hypoplasia is one of the predominant and shared features among infants and children with ASD (Courchesne et al., 1994; Allen, 2005). A smaller cerebellum has been linked to the administration of high doses of VPA, with evidence from pediatric use in humans during childhood years (10-year-old child, case report) (Ghosh et al., 2011) and after repeated prenatal exposure (E10–12) in an experimental rat model (Main and Kulesza, 2017).
4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors
2021, Cell ReportsCitation Excerpt :Although the neocortex has historically been regarded as the principal brain region giving rise to ASDs, cerebellar injury at birth carries the largest single non-heritable risk for ASD (Wang et al., 2014), and loss of Purkinje cells (PCs) is one of the salient anatomical pathologies in postmortem brain samples of individuals with ASD (Palmen et al., 2004; Skefos et al., 2014; Wegiel et al., 2014). Neuronal activity has been observed in the posterior cerebellar hemispheres following cognitive tasks such as attention shifting or verbal working memory tasks (Allen et al., 1997; Desmond et al., 1997), indicating that damage to this region could underlie difficulties in problem solving and attention-shifting impairments, both of which are characteristics of autistic people (Courchesne et al., 1994). Interestingly, emotional outbursts, difficulty understanding social cues, mood changes, and repetitive behaviors are also present in individuals with tumors, injuries, or congenital defects affecting the cerebellum (Bolduc et al., 2011).
Dyspraxia, motor function and visual-motor integration in autism
2014, Behavioural Brain ResearchA magnetic resonance imaging study of Cerebellar volume in tuberous sclerosis complex
2013, Pediatric NeurologyCitation Excerpt :The cerebellum plays an important role in learning, motor control, and memory [10,11]. Structural abnormalities including congenital lesions and aberrant structure are strongly associated with cognitive impairment [28,33,44], and there is a growing body of literature reporting on the potential role of the cerebellum in autism [44-47]. In tuberous sclerosis complex specifically, the presence of tubers in the cerebellum has been linked to autism [26,33].
An emergence of technological aids using machine learning algorithms to curtail the mounting manifestation of dyspraxia
2024, Multimedia Tools and ApplicationsCentral Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder
2021, Frontiers in Integrative Neuroscience