Elsevier

The Lancet

Volume 300, Issue 7789, 9 December 1972, Pages 1223-1224
The Lancet

EFFECT OF WEIGHT-LOSS ON PLASMA AND URINARY LEVELS OF URIC ACID

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Abstract

Fifteen overweight subjects, ten men and five women, six of them with gout, reduced their weight on a low-calorie diet. Plasma and urinary levels of uric acid were estimated while the subjects were taking a low-purine diet before and after the period of weight-loss, which ranged from 4 to 22 kg. After weight-loss, plasma-uric-acid fell in twelve of the fifteen subjects by a mean decrease of 0·8 mg. per 100 ml. Changes in urinary urate were not consistent. This influence of body-weight upon the plasma level of uric acid may be responsible for the association between these two variables which has been observed in epidemiological and clinical studies.

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