ORIGINAL ARTICLESDELETERIOUS EFFECT OF INTRA-ARTICULAR HYDROCORTISONE
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Cited by (98)
Escinosome thermosensitive gel optimizes efficacy of CAI-CORM in a rat model of rheumatoid arthritis
2023, Journal of Controlled ReleaseEFFECTIVENESS OF INTRA-ARTICULAR INJECTIONS OF SODIUM HYALURONATE, CORTICOSTEROIDS, PLATELET-RICH PLASMA ON TEMPOROMANDIBULAR JOINT OSTEOARTHRITIS: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
2022, Journal of Evidence-Based Dental PracticeCitation Excerpt :Subgroup analyses on age and gender included in our NMA indicated that female and elderly patients respond poorly to CCS intra-articular injection treatment. Injectables particularly CCS, which is often debated in literature,69 should be given with caution in the clinics. The proposed mechanism explaining the different effects of CCS — not only injections targeting muscle and joint, but also oral, inhaled, topical use targeting other diseases – on subgroups of patients is absent in current literature, which predicted future trends to encourage more clinical trials with large sample size to substantiate the effect of CCS on different age groups, and gender difference.
Efficacy of a hybrid system of hyaluronic acid and collagen loaded with prednisolone and TGF-β3 for cartilage regeneration in rats
2019, Journal of Drug Delivery Science and TechnologyDrug-fortified liposomes as carriers for sustained release of NSAIDs: The concept and its validation in the animal model for the treatment of arthritis
2018, European Journal of Pharmaceutical SciencesIdentification of antibodies against extracellular matrix proteins in human osteoarthritis
2018, Biochemical and Biophysical Research CommunicationsCitation Excerpt :It is also tempting to speculate that OA patients with high concentrations of autoantibodies might benefit from a local or systemic immune suppressive or immune modulatory therapy targeting B cells. In this context it is interesting that intraarticular cortisone therapy has been reported to exacerbate disease progression in some cases of OA [26], even though it is regarded as safe [27]. Cortisone has been shown to drive immunoglobulin synthesis in plasma cells under pro-inflammatory co-stimulation [28].
Surgical Versus Nonsurgical Management of Degenerative Joint Disease
2018, Oral and Maxillofacial Surgery Clinics of North AmericaCitation Excerpt :These adverse effects include atrophy of the adjacent skin, destruction of the cartilage, and condylar resorption. Most studies report arthropathy and condylar degeneration after multiple corticosteroid injections, but there are also a few studies in humans that show resorption after a single injection.29–33 The factors that are involved in condylar resorption after a single use are unclear.