ORIGINAL ARTICLESTREATMENT OF TETANUS: SEVERE BONE-MARROW DEPRESSION AFTER PROLONGED NITROUS-OXIDE ANESTHESIA
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Cited by (234)
A health-based recommended occupational exposure limit for nitrous oxide using experimental animal data based on a systematic review and dose-response analysis
2021, Environmental ResearchCitation Excerpt :As a consequence, N2O is one of the most used inhalation anaesthetics, next to halogenated substances, such as sevoflurane, isoflurane, desflurane, and halothane. Since the mid-1950s, however, concerns have been raised regarding potential toxic effects of N2O, followed by concerns for potential risks to the health of staff exposed on a daily basis over many years during their employment in the healthcare sector (Lassen et al., 1956; Linde and Bruce, 1969). These concerns led to further research being conducted among operating room staff, midwives, dentists, dental surgeons, dental assistants, and workers in veterinary practices (Lewinska et al., 2005; Axelsson et al., 1996; Rowland et al., 1992; Ward and Byland, 1982).
A Critical Appraisal of the Effects of Anesthetics on Immune-system Modulation in Critically Ill Patients With COVID-19
2021, Clinical TherapeuticsCitation Excerpt :Although these effects were first demonstrated >100 years ago, research to date has shown that at concentrations used clinically, different anesthetics affect the functions of the inflammatory response in a diverse manner9 (Table II). Therefore, the development of therapeutic approaches seems prudent for preventing iatrogenic harm that may lead to dysregulation of this inflammatory process and increased morbidity and mortality.77 The effects of anesthetics on immunomodulation of inflammation are complex, and in patients with COVID-19, the choice and use of these agents must be highly dependent on the immune status, especially in those with obesity, in whom the inflammation-induced synergistic conversion of tissue-resident macrophages to an M1-like phenotype and the expression of cytokines and adipokines by adipocytes will aggravate the inflammatory status.78–80
Nitrous oxide and vitamin B12 in sickle cell disease: Not a laughing situation
2020, Molecular Genetics and Metabolism ReportsEuropean Society of Anaesthesiology Task Force on Nitrous Oxide: a narrative review of its role in clinical practice
2019, British Journal of AnaesthesiaCitation Excerpt :In rodents, a teratogenic effect of N2O was shown for high concentrations (up to 75 vol%) over long periods (24 h).73,74 The negative effects associated with prolonged N2O sedation in severely diseased patients were described in 1956.75 Toxicity depends on duration of exposure: continuous administration for 6 h did not cause any adverse effects, whereas 12 and 24 h exposures showed signs of bone marrow toxicity.76