Elsevier

Biological Psychiatry

Volume 42, Issue 10, 15 November 1997, Pages 959-961
Biological Psychiatry

Brief report
Harm avoidance dimension of the tridimensional personality questionnaire and serotonin-1A activity in depressed patients

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    Ottenbreit and Dobson (2004) outlined the studies on avoidance and depression that have variously conceptualized avoidance as a coping strategy, a problem-solving style, and a personality dimension. These studies have supported an association between avoidance and depression (e.g., Blalock & Joiner, 2000; Davila, Hammen, Burge, Paley, & Shannon, 1995; D’Zurilla, Chang, Nottingham, & Faccini, 1998; Hansenne et al., 1997; Kuyken & Brewin, 1994; Spurrell & McFarlane, 1995). However, the lack of an integrative and valid measure of avoidance has made it difficult to compare results across studies.

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    Research has shown consistent support for a relationship between HA and depression. For example, Hansenne et al. (1997) identified a positive relationship between increased serotonergic activity and HA, as well as an association between severity of depression, as assessed by the Hamilton Depression Rating Scale (HDRS; Hamilton, 1960, as cited in Hansenne et al., 1997), and HA in a group of 21 depressed inpatients. Despite the positive association of HA with depression, research examining the stability of HA has revealed inconsistent patterns over time.

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