Aerobic capacity in adults with various congenital heart diseases☆
Section snippets
Patient population
A total of 5,733 patients are listed in the database at the University of Toronto Congenital Cardiac Center for Adults. Listed patients include inactive and actively followed patients. Late mortality (>18 years) occurred in 295 patients. Cardiopulmonary exercise tests were performed in 475 patients (230 male and 245 female patients) who attended the clinic as outpatients for follow-up and enrolled in the study. Six major diagnostic groups: ASD, CCTGA, Ebstein, Fontan, Mustard, and repaired ToF
Aerobic capacity
A significant decrease in maximal oxygen consumption with aging was found in patients with ASD (p <0.0001), CCTGA (p = 0.01), and ToF (p <0.0001). In Ebstein (p = 0.270), Fontan (p = 0.182) and Mustard (p = 0.188) patients, however, no significant decline was observed. Compared with healthy subjects, severely diminished maximal oxygen consumption values were found in all diagnostic groups across age (Figure 1) There was a large variation in the results of maximal oxygen consumption in all
Discussion
In the present study severely diminished aerobic capacity was revealed in all groups with congenital heart disease compared with a healthy population. A similar pattern was found regarding static lung function.
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Cited by (0)
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This study was supported in part by The Norwegian Association for Children with Congenital Heart Disorder, The Norwegian Lung and Heart Association, the National Foundation of Public Health in Norway, Oslo, Norway; and The National Heart Research Fund, Leeds, United Kingdom.