Chapter 20 - Drinking to Dependence Risk Factors in Nonhuman Primates
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Studies using macaque monkeys to address excessive alcohol drinking and stress interactions
2017, NeuropharmacologyCitation Excerpt :And finally, rats have low levels of 5β-reduced neuroactive steroids indicating species differences in neuroactive metabolites of adrenal steroids that may contribute to the subjective effects of alcohol (Helms et al., 2012c; Morrow et al., 2006; Porcu et al., 2009). Given the translation potential of old world macaques and baboons, these NHPs have been particularly useful for addressing stress as an etiological factor in AUDs (Barr and Goldman, 2006; Cederbaum et al., 2009; Grant and Bennett, 2003; Grant et al., 2014). In comparisons to humans, macaque monkeys have similar alcohol absorption and metabolism rates and can self-administer large quantities of alcohol over months and years (Baker et al., 2014; Green et al., 1999; Vivian et al., 2001).
Chronic ethanol self-administration in macaques shifts dopamine feedback inhibition to predominantly D2 receptors in nucleus accumbens core
2016, Drug and Alcohol DependenceCitation Excerpt :Alcohol use disorders are a major public health concern and, as such, determining the neurobiological basis of alcoholism in search of pharmacotherapeutic targets has been an area of much research. Due to the physiological, genetic and behavioral similarities between nonhuman primates and humans, nonhuman primate models of human disease states are thought to possess high translational validity (Grant et al., 2014). Similarities between nonhuman primates and humans are particularly relevant in the study of voluntary ethanol drinking as nonhuman primates consume ethanol with similar daily intake to human alcoholics (Grant et al., 2008; Majchrowicz and Mendelson, 1970).
Taste responsiveness of spider monkeys to dietary ethanol
2019, Chemical SensesChronic alcohol self-administration in monkeys shows long-term quantity/frequency categorical stability
2014, Alcoholism: Clinical and Experimental ResearchAdrenal steroid hormones and ethanol self-administration in male rhesus macaques
2014, Psychopharmacology