Elsevier

Brain and Development

Volume 17, Issue 1, January–February 1995, Pages 52-56
Brain and Development

Sleep disorders in tuberous sclerosis: a polysomnographic study

https://doi.org/10.1016/0387-7604(94)00118-HGet rights and content

Abstract

Overnight polysomnography was performed in 10 subjects with tuberous sclerosis (TS) and partial epilepsy in order to investigate the relationships between sleep organization, sleep disorders and epilepsy. Sleep architecture abnormalities were observed in 9 cases. Compared with ten healthy age-matched controls, the TS group showed a shorter total sleep time, a reduced sleep efficiency, a higher number of awakenings and stage transitions, an increased wake after sleep onset and stage 1 and a decreased REM sleep. Children with seizures showed a more disrupted sleep architecture compared with seizure-free children. Sleep disorders in TS were mainly due to sleep-related epileptic events and were more evident in children who showed large bifrontal or temporal tubers on MRI.

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    In the more recent TOSCA database study involving over 2000 TSC patients, sleep difficulties were the second most common neuropsychiatric symptom, reported in 44% of patients (de Vries et al., 2018). Polysomnographic studies objectively documented sleep abnormalities in 9 of 10 TSC patients, including reduced total sleep time and efficiency, increased awakenings, and reduced REM sleep (Bruni et al., 1995). In addition to causing disruptive insomnia and excessive daytime sleepiness, these sleep disturbances may exacerbate neurological comorbidities of TSC, such as epilepsy, cognitive dysfunction, and neuropsychiatric symptoms.

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