Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain
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2017, NeuroscienceCitation Excerpt :IL-6 has been shown to mediate both pro- and anti-inflammatory responses (Schneiders et al., 2015), and this dual action of IL-6 has been attributed to the presence of both membrane bound and soluble forms of the IL-6 receptor (IL-6R) (Roth et al., 2004a; Schaper and Rose-John, 2015). Under basal conditions IL-6 and IL-6R mRNA are expressed in the brain in discrete regions and it is believed that both neurons and glia express IL-6 and IL-6R (Brown et al., 1994; Gadient and Otten, 1994a,b, 1995, 1997; Rhodes et al., 2002; Schobitz et al., 1992, 1993a; Vallieres and Rivest, 1997, 1999; Balschun et al., 2004). In the spleen, under basal conditions the level of IL-6 mRNA is extremely low (Brown et al., 1994).
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