Influence of serotonin on lymphokine secretion in vitro

doi:10.1016/0192-0561(85)90052-9

International Journal of Immunopharmacology

Volume 7, Issue 6, 1985, Pages 889-896

International Journa...

https://doi.org/10.1016/0192-0561(85)90052-9 Get rights and content

Abstract

It was found that serotonin can induce the secretion of a chemotactic activity for polymorphonuclear granulocytes and the secretion of charge-changing lymphokines in lymphocyte cultures derived from guinea pigs and mice. The serotonin antagonists methysergide, pizotiphen, cyproheptadine and ketanserin inhibited the secretion of the serotonin-elicited factors, whereas the histamine-type 2 antagonist metiamide had no inhibitory effect. Moreover, the production of Concanavalin A-induced lymphokines (migration inhibition factor for macrophages, chemotactic factor for polymorphonuclear granulocytes and for thymocytes, charge-changing lymphokines) was suppressed in the presence of serotonin in the lymphocyte cultures. The fractionation of the supernatants derived from the serotonin-stimulated lymphocytes revealed that serotonin produced an activity with a molecular weight of 40 kDA in the presence on which the Con A-elicited response was completely inhibited. These findings support the regulatory role of serotonin with respect to immune reactions.

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Influence of serotonin on lymphokine secretion in vitro

Abstract

Immunology Today

Eur. J. Pharmac.

Life Sci.

Clin. Immun. Immunopath.

J. cell Biol.

Cell. Immun.

J. Pharmac. exp. Ther.

T-cell dependent mast cell degranulation and release of serotonin in murine delayed-type hypersensitivity

J. exp. Med.

Localization of leukocytesin sites of delayed-type hypersensitivity and in lymph nodes: dependence on vasoactive amines

Immunology

Serotonin and its precursors as modulators of the immunological responsiveness in mice

J. Medicine

Lumphokines and thrombosis I. Thrombocyte aggregating activity released by human lymphocytes stimulated with concanavalin A

Acta allerg.

Peripheral physiological and pharmacological actions of indolealkylamines

Serotonin-induced production of a monocyte chemotactic factor by human peripheral blood leukocytes

J. Immun.