Research paper
MPOA and BNST lesions in male Syrian hamsters: Differential effects on copulatory and chemoinvestigatory behaviors

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Abstract

Electrolytic lesions were made in the medial preoptic area (MPOA) and bed nucleus of the stria terminalis (BNST) to evaluate their participation in the neural regulation of copulatory and chemoinvestigatory behaviors in male hamsters. Damage to either the MPOA or the BNST caused severe deficits in copulatory performance in a subset of the animals in each group. In the MPOA group all males displaying severe deficits had lesions which included a small central region of the caudal MPOA. In the BNST group, animals with severe copulatory deficits all had large lesions which covered most of both the medial and lateral parts of the nucleus. In contrast, MPOA and BNST lesions differentially affected chemoinvestigatory behaviors. MPOA lesions did not affect any of the males' anogenital investigation rates or attraction to female odors, even though some of these hamsters had stopped mating completely. Males with BNST lesions, on the other hand, all displayed significant reductions in their chemoinvestigatory responding even though the majority of them continued to mate normally. We suggest that the MPOA and BNST may in part regulate male sexual behavior by differentially responding to ‘attractant’ and ‘mounting’ substances within female hamster vaginal secretion.

References (75)

  • P.C. Doherty et al.

    Uptake and retention of androgen in neurons of the brain of the golden hamster

    Brain Res.

    (1981)
  • R.L. Doty et al.

    Olfactory control of sexual behavior in the male and early-androgenized female hamster

    Horm. Behav.

    (1971)
  • D.E. Emery et al.

    Copulatory behavior in male rats with lesions in the bed nucleus of the stria terminalis

    Physiol. Behav.

    (1976)
  • G.A. Eskes

    Neural control of the daily rhythm of sexual behavior in the male golden hamster

    Brain Res.

    (1984)
  • W.T. Greenough et al.

    Sex differences in dendritic patterns in hamster preoptic area

    Brain Res.

    (1977)
  • S. Hansen

    Spinal control of sexual behavior: effects of intrathecal administration of lisuride

    Neurosci. Lett.

    (1982)
  • S. Hansen et al.

    Effects of ibotenic acid-induced neuronal degeneration in medial preoptic area and the lateral hypothalamic area on sexual behavior in the male rat

    Brain Res.

    (1982)
  • S. Hansen et al.

    5-Hydroxytryptamine-thyrotropin-releasing hormone interactions in the spinal cord: effects on parameters of sexual behavior in the male rat

    Neurosci. Lett.

    (1983)
  • B.L. Hart

    Medial preoptic-anterior hypothalamic lesions and sociosexual behavior of male goats

    Physiol. Behav.

    (1986)
  • B.L. Hart et al.

    Effects of medial preoptic-anterior hypothalamic lesions on mating behavior of male cats

    Brain Res.

    (1973)
  • M.N. Lehman et al.

    Stria terminalis lesions alter the temporal pattern of copulatory behavior in the male golden hamster

    Behav. Brain Res.

    (1983)
  • M.N. Lehman et al.

    Vomeronasal and olfactory pathways to the amygdala controlling male hamster sexual behavior: autoradiographic and behavioral analyses

    Brain Res.

    (1982)
  • M.N. Lehman et al.

    Evidence for a ventral non-strial pathway from the amygdala to the bed nucleus of the stria terminalis in the male golden hamster

    Brain Res.

    (1983)
  • R.D. Lisk et al.

    The effects of sexual experience and frequency of testing on retention of copulatory behavior following castration in the male hamster

    Behav. Neur. Biol.

    (1980)
  • F. Macrides et al.

    Responses of the male golden hamster to vaginal secretion and dimethyl disulfide: attraction versus sexual behavior

    Behav. Biol.

    (1977)
  • C.W. Malsbury

    Facilitation of male rat copulatory behavior by electrical stimulation of the medial preoptic area

    Physiol. Behav.

    (1971)
  • A. Merari et al.

    Characteristics of exaggerated sexual behavior induced by electrical stimulation of the medial preoptic area in male rats

    Brain Res.

    (1975)
  • M. Meredith

    Sensory physiology of pheromone communication

  • G. Paxinos et al.

    Substance-P projections to the entopeduncular nucleus, the medial preoptic area, and the lateral septum

    Neurosci. Lett.

    (1978)
  • J.B. Powers et al.

    Androgenic regulation of chemoinvestigatory behaviors in male and female hamsters

    Horm. Behav.

    (1983)
  • J.B. Powers et al.

    Male hamster sociosexual behaviors: effects of testosterone and its metabolites

    Physiol. Behav.

    (1985)
  • A.G. Singer et al.

    Chemical studies of hamster vaginal discharge: male behavioral responses to a high molecular weight fraction require physical contact

    Physiol. Behav.

    (1984)
  • J.C. Slimp et al.

    Heterosexual, autosexual, and social behavior of adult male rhesus monkeys with medial preoptic-anterior hypothalamic lesions

    Brain Res.

    (1978)
  • H. Szechtman et al.

    Preoptic knife cuts and sexual behavior in male rats

    Brain Res.

    (1978)
  • R.J. Valcourt et al.

    Penile reflexes and copulatory behavior in male rats following lesions in the bed nucleus of the stria terminalis

    Brain Res. Bull.

    (1979)
  • K.L. Weller et al.

    Afferent connections to the bed nucleus of the stria terminalis

    Brain Res.

    (1982)
  • J.M. Wheeler et al.

    The role of the anterior hypothalamus-preoptic area in the regulation of male reproductive behavior in the lizard, Anolis carolinensis: lesion studies

    Horm. Behav.

    (1978)
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