ArticlePlacebo-controlled acute dosage naltrexone study in young autistic children
References (61)
- et al.
Naloxone and play fighting in juvenile rats
Pharmacol Biochem Behav
(1982) New techniques for the analysis of the human sleep-wake cycle
Brain Dev
(1986)- et al.
The adrenocorticotrophic hormone (4–9) analog ORG 2766 in autistic children: effects on the organization of behavior
Biol Psychiatry
(1992) - et al.
The adrenocorticotrophic hormone (4–9) analog ORG-2766 benefits autistic children — Report on a second controlled clinical trial
J Am Acad Child Adolesc Psychiatry
(1992) - et al.
Naltrexone in autistic children: behavioral symptoms and attentional learning
J Am Acad Child Adolesc Psychiatry
(1993) - et al.
Naltrexone in autistic children: an acute open dose range tolerance trial
J Am Acad Child Adolesc Psychiatry
(1989) - et al.
CSF beta-endorphins in childhood neuropsychiatric disorders
Brain Dev
(1990) - et al.
The dexamethasone and cortisol suppression test in depression: β-endorphin as a useful marker
Psychoneuroendocrinology
(1987) - et al.
Effects of naloxone-HCl on cortisol levels in patients with affective disorder and normal controls
Psychiatry Res
(1981) - et al.
Naltrexone in young autistic children: a double-blind, placebo-controlled crossover study
J Am Acad Child Adolesc Psychiatry
(1995)
Effects of naltrexone on infantile autism
Lancet
Comparison of the effect of belaendorphin and morphine on exploralory and socio-sexual behavior in the male rat
Eur J Pharmacol
Neuropeptides and social behavior of rats tesled in dyadic encounters
Neuropeptides
A neurochemical theory of autism
Trends Neurosci
Opioid blockade and social comfort in chicks
Pharmacol Biochem Behav
Loss of the cortisol response to naltrexone in Alzheimer's Disease
Biol Psychiatry
Reduction of elevated CSF beta-endorphin by fenfluramine in infantile autism
Pediatr Neurol
The determination of cortisol in human plasma: evaluation and comparison of seven assays
Clin Chim Acta
Low doses of betaendorphin increase social contacls of rats tested in dyadic encounters
Life Sci
Low plasma immunoreactive β-endorphin levels in autism
J Am Acad Child Adolesc Psychiatry
Initiatory and reactive behaviour in young children with a pervasive developmental disorder: two independent components in communicative behaviour for distinguishing subgroups
Eur Child Adolesc Psychiatry
The Aberrant Behavior Checklist: a behavior rating scale for the assessment of treatment effects
Am J Ment Defic
Naloxone augments electrophysiological signs of selective attention in man
Nature
Effects of acute naltrexone on locomotor activity in autistic children
Soc Neurosci Abstr
Effects of naloxone upon prolactin and cortisol in normal women
Effects of acutely administered naltrexone on social behavior of autistic children
Soc Neurosci Abstr
Psychopharmacological approaches to childhood psychotic disorders
Differences in the structure of social behavior of autistic children and non-autistic retarded controls
J Child Psychol Psychiatry
Behavioral effects of ORG 2766, a synthetic analog of the adrenocorticotrophic hormone (4–9) in 14 outpatient autistic children
J Autism Dev Disord
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Systematic Review and Meta-analysis: Pharmacological and Nonpharmacological Interventions for Persistent Nonepisodic Irritability
2023, Journal of the American Academy of Child and Adolescent PsychiatryCitation Excerpt :In total, 101 intervention studies were included in the meta-analysis, comprising 6,953 youth with persistent non-episodic irritability (study sample sizes ranged from 8 to 579; Figure 1 presents the PRISMA flowchart). Descriptions of the 101 articles (42 open trial, 59 RCT) included in this systematic review and meta-analysis can be found in Table 1.28-125 ( Included studies targeted a range of ages, with youth ages 2+ years being represented in the current meta-analysis, suggesting that results from this meta-analysis are representative of the full preschool through adolescent developmental periods.
The pediatric psychopharmacology of autism spectrum disorder: A systematic review - Part I: The past and the present
2021, Progress in Neuro-Psychopharmacology and Biological PsychiatryMeta-analysis: Pharmacologic Treatment of Restricted and Repetitive Behaviors in Autism Spectrum Disorders
2021, Journal of the American Academy of Child and Adolescent PsychiatryCitation Excerpt :Figure 3E depicts a funnel plot of oxytocin trials on RRB that does not show any evidence of publication bias (Egger intercept = −2.19 ± 1.44, CI = −6.20 to 1.82, p = .20). Four trials including 97 participants examined the effects of naltrexone on RRB symptoms in ASD.66-69 Naltrexone was not associated with a change in RRB outcomes compared to placebo (SMD = −0.07, SE = 0.16, 95% CI = −0.38 to 0.25, z = −0.41, p = .68) (Figure 2).
Psychopharmacologic intervention for adults with autism spectrum disorder: A systematic literature review
2016, Research in Autism Spectrum DisordersCitation Excerpt :While the results of several placebo-controlled trials have indicated that citalopram and clomipramine have not resulted in significant reductions in repetitive behaviour in children with ASD, findings regarding fluoxetine have been mixed (Cook, Rowlett, Jaselskis, & Leventhal, 1992; DeLong, Teague, & Kamran, 1998; Gordon, State, Nelson, Hamburger, & Rapoport, 1993; Hollander et al., 2005; King et al., 2009; Remington, Sloman, Konstantareas, Parker, & Gow, 2001; Sanchez et al., 1996). The results of several trials have yielded preliminary evidence for the efficacy of atomoxetine (Arnold et al., 2006; Harfterkamp et al., 2012; Posey et al., 2006; Troost et al., 2006), naltrexone (Kolmen, Feldman, Handen, & Janosky, 1995; Willemsen-Swinkels, Buitelaar, Weijnen, & van Engeland, 1995) and pentoxifylline for irritability, self-injurious behaviour and hyperactivity in children with ASD. In addition, there is promising support for the efficacy of methylphenidate in treating symptoms of attention deficit/hyperactivity disorder in this population (Handen, Johnson, & Lubetsky, 2000; Network, 2005).
Naltrexone treatment reverses astrocyte atrophy and immune dysfunction in self-harming macaques
2015, Brain, Behavior, and ImmunityAltered circadian patterns of salivary cortisol in low-functioning children and adolescents with autism
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