Depressive and obsessive-compulsive symptoms in hyperserotonemic parents of children with autistic disorder
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2023, Pharmacology Biochemistry and BehaviorThe developmental disruptions of serotonin signaling may involved in autism during early brain development
2014, NeuroscienceCitation Excerpt :This platelet storage pool has been assessed by measuring serotonin in the whole blood or in platelet-rich plasma (PRP). A potential role of the serotonergic system in autism has been suggested by the finding of hyperserotonemia (the increase of serotonin in blood) in a proportion of autistic subjects and a well-replicated change since the research by Schain and Freedman in 1961 (Hanley et al., 1977; Cook et al., 1993, 1994; Kahne et al., 2002; McNamara et al., 2008). This result has been extended with the recognition that blood serotonin is also elevated in their first-degree relatives (Abramson et al., 1989; Leboyer et al., 1999; Piven and Palmer, 1999).
Inhibitory and Excitatory Systems in Autism Spectrum Disorders
2013, The Neuroscience of Autism Spectrum DisordersInhibitory and Excitatory Systems in Autism Spectrum Disorders
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2008, Clinical Assessment and Intervention for Autism Spectrum DisordersSignificance of abnormalities in developmental trajectory and asymmetry of cortical serotonin synthesis in autism
2005, International Journal of Developmental Neuroscience
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Julie Spohn, B.A., was an undergraduate student at the University of Chicago when this study was conducted.