Original articleImmunotherapy with a standardized Dermatophagoides pteronyssinus extract: III. Systemic reactions during the rush protocol in patients suffering from asthma
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Systemic Allergic Reactions and Anaphylaxis Associated with Allergen Immunotherapy
2022, Immunology and Allergy Clinics of North AmericaCitation Excerpt :Other studies also show a higher rate of SRs in patients with asthma.27–29 Seventy percent of patients with an FEV1 less than 80% predicted versus 12% with an FEV1 ≥ 80% of predicted receiving rush SCIT experienced an SR in a prospective trial of 125 patients.30 Therefore, routine clinical screening of patients with asthma and, where necessary, measurement of lung function (peak flow spirometry) is recommended prior to SCIT administration.2
Management of allergy in severe asthma patients
2020, Revue des Maladies Respiratoires ActualitesThe safety profile of subcutaneous allergen immunotherapy in children with asthma in Hangzhou, East China
2017, Allergologia et ImmunopathologiaRisk factors for fatal and nonfatal reactions to subcutaneous immunotherapy: National surveillance study on allergen immunotherapy (2008-2013)
2016, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :A retrospective survey on near-FRs concluded that having an FEV1 less than 70% conferred an increased risk for severe reactions.11 A prospective survey on aeroallergen rush immunotherapy also found that patients with FEV1 less than 80% were at greater risk of systemic reactions.15 Although FEV1 provides valuable information regarding asthma severity, standardized surveys to measure asthma control have been developed in recent years and are widely used in clinical practice to assess the adequacy of asthma medication regimens and the risk for exacerbations.16,17
Improving the safety of immunotherapy
2014, Journal of Allergy and Clinical Immunology: In PracticeInjection Immunotherapy for Inhalant Allergens
2014, Middleton's Allergy: Principles and Practice: Eighth Edition