Effect of naltrexone upon self-injurious behavior, learning and activity: a case study

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Abstract

Naltrexone significantly attenuated self-injurious behavior in a 20-year-old mildly retarded autistic male patient. The patient was videotaped daily and behavior was evaluated with a time-sampling procedure. Behavioral ratings of SIB frequency, SIB severity, and activity were collected automatically with a computerized system. Learning and memory were tested on a weekly basis with a modification of a paired associate learning test (PALT). Treatment with naltrexone resulted in (a) attenuation of SIB in the unstructured setting and (b) improvements in learning and memory without influencing activity levels.

References (36)

  • A.F.T. Arnsten et al.

    Naloxone augments electrophysiological signs of selective attention in man

    Nature

    (1983)
  • R.P. Barrett et al.

    Effects of naloxone and naltrexone on self-injury: a double blind, placebo-controlled analysis

    Am. J. Ment. Retard.

    (1989)
  • J.D. Belluzi et al.

    Enkephalin may mediate euphoria and drive-reduction reward

    Nature

    (1977)
  • G.A. Bernstein et al.

    Effects of narcotic antagonist on self-injurious behavior: A single case study

    J. Am. Acad. Child Adoles. Psychiatry

    (1987)
  • M. Campbell et al.

    Naltrexone in infantile autism

    Psychopharmacol. Bull.

    (1988)
  • C. Castellano

    Effects of morphine and heroin on discriminate learning and consolidation in mice

    Psychopharmacology (Berlin)

    (1975)
  • DeMet, E. M.; Sandman, C. A. Models of the opiate system in self-injurious behavior: A reply. Am. J. Ment. Retard.; in...
  • S.I. Deutsch

    Rationale for the administration of opiate antagonists in treating infantile autism

    Am. J. Ment. Retard.

    (1989)
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