Original articleLongitudinal changes in serum cholesterol in man: An epidemiologic search for an etiology
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2016, International Journal of CardiologyCitation Excerpt :After adjustment for age and sex, LLT use explained 79% of the fall in TC in the group with a history of CHD (R2 = 0.79, p < 0.001) but accounted for only 27% of the fall in those without a history of CHD of borderline statistical significance (R2 = 0.27, p = 0.06). Population studies indicate that serum TC levels have been declining from 1960 to the first decade of the millennium [8–32], and LLT use in the general population has increased from 1980 to 2006 [33–36]. The fall in TC and increase in LLT in the general population from the world literature has been superimposed on the GRACE and CONCORDANCE data in Fig. 4.
Aging and dyslipidemia: A review of potential mechanisms
2015, Ageing Research ReviewsCitation Excerpt :In women, the TG concentrations increase throughout their life, and are higher in those using estrogens all the time (Gobal and Mehta, 2010). Nevertheless, in a few studies including older persons, TC in the elderly has been reported to decrease with age (Table 1) (Gillum et al., 1982; Hershcopf et al., 1982). Most investigators consider that the decrease of TC as age increases may represent cohort, period, and/or survivorship effects rather than a true decline (Newschaffer et al., 1992).
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- 1
Present address: The Rockefeller University, New York, NY 10021.
- 2
Present address: Scarsdale Medical Center, 259 Heathcote Road, Scarsdale, NY 16583.
- 3
Present address: University of South Florida College of Medicine, Tampa, FL 33612.