Nicotinic receptor agonists exhibit anxiolytic-like effects on the elevated plus-maze test
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2021, Behavioural Brain ResearchCitation Excerpt :Nicotine is an active alkaloid phytoconstituent present in tobacco leaves and considered cardinal for inducing plethora of behvioral effects contributing to tobacco addiction. The most notable actions of nicotine consumption are related to modulation of anxiety measures in humans as well as in rodents, wherein acute administration of nicotine is purported to elicit both anxiolytic [1–3] and anxiogenic effects [4–6]. On the other hand, tolerance to the effect of nicotine on anxiety is reported on chronic consumption [7] and subsequent withdrawal leads to increased anxiety measures in rodents [8,9].
Loss of Lypd6 leads to reduced anxiety-like behaviour and enhanced responses to nicotine
2018, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Therefore, since we excluded the confounding of motor-depressant actions of nicotine in the dose used for EZM, the differential effects of nicotine in the two tests might reflect effects on different aspects of emotionality. Several studies have demonstrated that nicotine exposure can increase or reduce anxiety-like behaviour (reviewed in (Picciotto et al., 2015)), depending on factors, including the nAChR subtypes that are activated or desensitized, the dose and treatment duration, as well as the brain area and neurotransmitter systems involved (Anderson and Brunzell, 2015; Besson et al., 2008; Brioni et al., 1993; Turner et al., 2010b). We have previously shown Lypd6 to be a negative modulator of nAChRs and therefore hypothesize that lack of Lypd6 enhances the sensitivity of nAChR to agonists.
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