Elsevier

Cognition

Volume 57, Issue 2, November 1995, Pages 109-128
Cognition

Other minds in the brain: a functional imaging study of “theory of mind” in story comprehension

https://doi.org/10.1016/0010-0277(95)00692-RGet rights and content

Abstract

The ability of normal children and adults to attribute independent mental states to self and others in order to explain and predict behaviour (“theory of mind”) has been a focus of much recent research. Autism is a biologically based disorder which appears to be characterised by a specific impairment in this “mentalising” process. The present paper reports a functional neuroimaging study with positron emission tomography in which we studied brain activity in normal volunteers while they performed story comprehension tasks necessitating the attribution of mental states. The resultant brain activity was compared with that measured in two control tasks: “physical” stories which did not require this mental attribution, and passages of unlinked sentences. Both story conditions, when compared to the unlinked sentences, showed significantly increased regional cerebral blood flow in the following regions: the temporal poles bilaterally, the left superior temporal gyrus and the posterior cingulate cortex. Comparison of the “theory of mind” stories with “physical” stories revealed a specific pattern of activation associated with mental state attribution: it was only this task which produced activation in the medial frontal gyrus on the left (Brodmann's area 8). This comparison also showed significant activation in the posterior cingulate cortex. These surprisingly clear-cut findings are discussed in relation to previous studies of brain activation during story comprehension. The localisation of brain regions involved in normal attribution of mental states and contextual problem solving is feasible and may have implications for the neural basis of autism.

References (62)

  • A.H. Attwood et al.

    The understanding and use of interpersonal gestures by autistic and Down's syndrome children

    Journal of Autism and Developmental Disorders

    (1988)
  • J. Avis et al.

    Belief-desire reasoning among Baka children: evidence for a universal conception of mind

    Child Development

    (1991)
  • D. Bailey et al.

    Physical validation of statistical parametric mapping

    Journal of Cerebral Blood Flow and Metabolism

    (1991)
  • S. Baron-Cohen

    The autistic child's theory of mind: a case of specific developmental delay

    Journal of Child Psychology and Psychiatry

    (1989)
  • S. Baron-Cohen

    Out of sight or out of mind?

    A naturalistic study of deception in autism

    Journal of Child Psychology and Psychiatry

    (1992)
  • S. Baron-Cohen et al.

    Mechanical, behavioural and intentional understanding of picture stories in autistic children

    British Journal of Developmental Psychology

    (1986)
  • S. Baron-Cohen et al.

    The brain basis of theory of mind: the role of the orbito-frontal region

    British Journal of Psychiatry

    (1994)
  • S. Baron-Cohen et al.

    Can children with autism recognize surprise?

    Cognition and Emotion

    (1993)
  • S. Baron-Cohen et al.

    Understanding other minds: Perspectives from autism

    (1993)
  • M.L. Bauman et al.

    Neuroanatomical observations of the brain in autism

  • G. Bottini et al.

    The role of the right hemisphere in the interpretation of figurative aspects of language

    Brain

    (1994)
  • D.M. Bowler

    Theory of mind in Asperger's syndrome

    Journal of Child Psychology and Psychiatry

    (1992)
  • V. Dasser et al.

    The perception of intention

    Science

    (1989)
  • J.-F. Démonet et al.

    The anatomy of phonological and semantic processing in normal subjects

    Brain

    (1992)
  • R.S.J. Frackowiak et al.

    Functional neuroanatomy of the human brain: positron emission tomography - a new neuroanatomical technique

    Journal of Anatomy

    (1994)
  • K.J. Friston et al.

    Comparing functional (PET) images: the assessment of significant change

    Journal of Cerebral Blood Flow and Metabolism

    (1991)
  • K.J. Friston et al.

    Localisation in PET images: direct fitting of the intercommisural (AC-PC) line

    Journal of Cerebral Blood Flow and Metabolism

    (1989)
  • U. Frith

    Autism: Explaining the enigma

    (1989)
  • U. Frith et al.

    Theory of mind and social adaptation in autistic, retarded and young, normal children

    (1994)
  • D. Frye et al.

    The cognitive basis of theory of mind

    (1994)
  • N. Geschwind

    Disconnection syndromes in animals and man

    Brain

    (1965)
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