Original articleNeuropsychological correlates of alogia and affective flattening in schizophrenia☆
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Neurocognitive and linguistic correlates of positive and negative formal thought disorder: A meta-analysis
2019, Schizophrenia ResearchUsing poverty of speech as a case study to explore the overlap between negative symptoms and cognitive dysfunction
2016, Schizophrenia ResearchCitation Excerpt :These include the assessment of clinical poverty of speech (i.e., alogia) using ratings made with a single item, which may have reduced the sensitivity of this instrument to detect more subtle differences across participants. While the present study employed a single item measure from the PANSS to assess clinical poverty of speech, the results are consistent with previous findings on the association between alogia and verbal fluency performance where poverty of speech was rated using various different instruments (Stolar et al., 1994; Joyce et al., 1996; Bowie et al., 2004; Berenbaum et al., 2008). Another more broad limitation involves the use of only a specific example relating to speech deficits to make inferences about the broad categories of negative symptoms and cognition.
The course of negative symptoms over the first five years of treatment: Data from an early intervention program for psychosis
2015, Schizophrenia ResearchCitation Excerpt :Nevertheless, the findings with reference to a stronger relationship of EPS and neural indices to expressive symptoms than motivational symptoms, are consistent with past reports (Gur et al., 2007; Kelley et al., 1999; Malla et al., 2002). In addition, consistent with some past findings, reduced expressiveness was correlated with lower performance on non-verbal rather than verbal tasks suggesting right hemisphere dysfunction (Mayer et al., 1985; Stolar et al., 1994). Both depression and anxiety have been identified as possible contributors to the appearance of negative symptoms (Lee et al., 2011; Millan et al., 2014; Schennach et al., 2015), and there is evidence that clinical interventions often bring about coincident improvement in mood and reduction in negative symptoms (Granholm et al., 2013; Turkoz et al., 2008).
A comparative study of the working memory multicomponent model in psychosis and healthy controls
2015, Comprehensive PsychiatryCitation Excerpt :These associations did not explain our main results, since we did not find associations with the digit span test and TMT. Negative symptoms have been associated with impairments in working memory and prefrontal cortex dysfunction in patients with psychosis [75–78]. Indeed, it has been hypothesized that they both are a consequence of dysfunction of shared neural pathways, such as dopamine hypoactivity in the prefrontal cortex [79].
Negative symptoms of schizophrenia: Clinical features, relevance to real world functioning and specificity versus other CNS disorders
2014, European NeuropsychopharmacologyCitation Excerpt :Investigations of affective flattening have found this symptom subdomain to be associated with impaired emotion processing in schizophrenia (Gur et al., 2006). Further, severity of alogia in schizophrenia has shown a relationship with verbal fluency performance (Stolar et al., 1994; Sumiyoshi et al., 2005). Motivational deficits in schizophrenia have also demonstrated cross-sectional relationships with discrete cognitive domains including executive function, visuomotor sequencing, working memory, and visual learning and memory deficits, but no consistent longitudinal relationship (Faerden et al., 2009b; Konstantakopoulos et al., 2011; Nakagami et al., 2010; Roth et al., 2004).
Impairment in verbal memory observed in first episode psychosis patients with persistent negative symptoms
2013, Schizophrenia Research
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This article is based in part on a dissertation submitted by Neal Stolar to the Graduate College of the University of Illinois; he was supported by a dissertation research fellowship awarded by the Scottish Rite Schizophrenia Research Program, N.M.J., U.S.A., with additional support provided by a fellowship awarded by Procter and Gamble.