Elsevier

Biological Psychiatry

Volume 37, Issue 6, 15 March 1995, Pages 410-413
Biological Psychiatry

Original article
Specific IgA antibody increases in schizophrenia

https://doi.org/10.1016/0006-3223(94)00176-4Get rights and content

IgA antibody levels in serum were examined in two groups of schizophrenic patients. All were diagnosed according to DSM-III-R criteria. One group of 36 males and 12 females were compared to historical controls. The other group consisted of 13 males off drugs for at least 3 months; these were compared with age -and sex-matched controls. An increase in specific IgA antibodies was found. More schizophrenics than controls showed IgA antibody levels above the upper normal limit to gliadin, beta-lactoglobulin, and casein.

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      Citation Excerpt :

      This connection between gluten exposure and psychiatric disorders was first hypothesized by FC Dohan who observed that psychiatric hospitalization rates in Europe strongly correlated with the amount of wheat consumption, which varied considerably during and immediately after World War II (Dohan, 1966a, 1966b). Since then, numerous studies and meta-analyses have examined the association of food antigens with schizophrenia and with varied results (Cascella et al., 2011; Dickerson et al., 2010; Jin et al., 2010; McLean, Wilson, St Clair, Mustard, & Wei, 2017; Reichelt & Landmark, 1995; Reichelt & Stensrud, 1998; Samaroo et al., 2010; Severance et al., 2010). In our studies, these gluten antibody profiles correlated with measures of GI inflammation (Severance et al., 2013; Severance, Alaedini, et al., 2012; Severance, Gressitt, et al., 2012).

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    Deceased.

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