Improvement in symptoms of depression and in an index of life stressors accompany treatment of severe hypertriglyceridemia☆
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2019, Journal of Affective DisordersCitation Excerpt :Therefore, statins by reducing inflammation and oxidative stress may help reduce the likelihood of cardiovascular events and depression. Lastly, it has also been suggested that statins improve brain perfusion and oxygenation (Glueck et al., 1993) and thus improve depression. Whatever the mechanism might be, the results of the current meta-analysis provide optimism for further investigating the efficacy of statins in larger trials to confirm these findings.
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2016, Journal of Affective DisordersUnfairness and the social gradient of metabolic syndrome in the Whitehall II Study
2007, Journal of Psychosomatic ResearchCitation Excerpt :Recent research proposed psychosocial characteristics such as chronic stress [17], work stress [18], job control [19], and social isolation [20] as plausible explanatory factors for one's social position and/or the metabolic syndrome. When considering separate components of the metabolic syndrome, psychological distress is associated with greater fasting glucose [21], blood pressure [22], lipids [23], insulin levels [24], central obesity [25], and triglycerides [26]. Psychosocial factors also influence behavioral risk factors such as smoking and physical inactivity [27] that have been found to be important determinants of metabolic disorders [28,29].
Vascular nutritional correlates of late-life depression
2006, American Journal of Geriatric PsychiatryCitation Excerpt :IF was also found to be correlated with cortisol levels, which are known to be elevated in depressed individuals.34 Another study indicated that a decrease in serum triglycerides was associated with a decrease in depressive symptoms among patients who underwent a year of treatment for hypertriglyceridemia.35 The authors speculated that increased triglycerides are causal in depression.
Behavioral implications of lowering cholesterol levels: A double-blind pilot study
2003, PsychosomaticsCitation Excerpt :Glueck et al.21 found that pharmacological and dietary treatment of hypertriglyceridemia was associated with a significant amelioration of depressive symptoms at 30 and 54 weeks. They suggested that the apparent antidepressant effects were possibly due to improved cerebral perfusion and oxygenation.21 Individual risk factors for experiencing behavioral change with cholesterol-lowering drug treatments are unknown.
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Supported by Jewish Hospital Medical Research Council Grant #790.