A novel biochemical model linking dysfunctions in brain melatonin, proopiomelanocortin peptides, and serotonin in autism☆
References (142)
- et al.
On the effect of melatonin upon human brain. Its possible therapeutic implications
Life Sci
(1971) - et al.
Failure of naloxone to reduce self-injurious behavior in two developmentally disabled females
Appl Res Ment Retard
(1986) - et al.
Efficacy and safety of fenfluramine in autistic children
J Am Acad Child Adolesc Psychiatry
(1988) - et al.
Psychopharmacology in child and adolescent psychiatry: A review of the past five years
J Am Acad Child Adolesc Psychiatry
(1988) - et al.
The biological basis for self-injury in the mentally retarded
Anal Intervent Dev Disabilities
(1982) Social cohesiveness, hypersexuality and irratability induced by p-CPA in the rat
Physiol Behav
(1976)- et al.
Effects of naloxone on self-injurious behavior: A case study
Appl Res Ment Retard
(1983) - et al.
Effects of morphine and naloxone on social attachment in infant guinea pigs
Pharmacol Biochem Behav
(1978) - et al.
Blood serotonin concentrations and fenfluramine therapy in autistic children
J Pediatr
(1986) - et al.
The dexamethasone suppression test in infantile autism
J Am Acad Child Psychiatry
(1985)
Effect of melatonin and pinealectomy on avoidance and exploratory activity in the rat
Physiol Behav
Effects of naltrexone on infantile autism
Lancet
Effects of naloxone on the nocturnal rise of rat pineal melatonin content
Eur J Pharmacol
Use of naltrexone as a provocative test for hypothalamic-pituitary hormone function
Pharmacol Biochem Behav
The opiomelanotropinergic neuronal and endocrine systems
Peptides
The EEG and rapid eye movements during REM sleep in normal and autistic children
Electroencephalogr Clin Neurophysiol
The auditory response in normal and autistic children during sleep
Electroencephalogr Clin Neurophysiol
A neurochemical theory of autism
Trends Neurosci
Endogenous opioids and social behavior
Neurosci Biobehav Rev
The neurochemical control of crying
Pharmacol Biochem Behav
Reduction of distress vocalization in chicks by opiate-like peptides
Brain Res Bull
Loss of the cortisol response to naltrexone in Alzherimer's disease
Biol Psychiatry
Morphine analgesia in grouped and isolated rats
Psychopharmacologica (Berlin)
Whole blood serotonin in autistics and normal subjects
J Child Psychol Psychiatry
Haloperidol in the treatment of infantile autism: Effects on learning and behavioral symptoms
Am J Psychiatry
Pineal-brain relationships
Brain serotonin concentration: Elevation following intraperitoneal administration of melatonin
Science
Physiology of neural pathway affecting CRH secretion
Fenfluramine response in high and low functioning autistic children
J Am Acad Child Adolesc Psychiatry
Effects of naloxone and naltrexone on self-injury: A double-blind placebo-controlled analysis
Am J Ment Retard
Brief report: The effects of fenfluramine and communication skills in autistic children
J Autism Dev Disord
Infant crying and maternal responsiveness
Child Dev
Effects of narcotic antagonists on self-injurious behavior: A single case study
J Am Acad Child Adolsc. Psychiatry
Effects of naloxone on prolactin and cortisol in normal women
Potential sites of action of pineal hormones within the neuroendocrine-reproductive axis
Corticotrophin-releasing factor regulates proopiomelanocortin messenger ribonucleic acid level in vivo
Neuroendocrinology
Annotation. Fenfluramine treatment of autism
J Child Psychol Psychiatry
Naltrexone in infantile autism
Psychopharmacol Bull
Pharmacotherapy for autistic childrren: A summary of research
Can J Psychiatry
Short-term efficacy and safety of fenfluramine in hospitalized preschool-age autistic children: An open study
Psychopharmacol Bull
Blood serotonin in schizophrenic children: A preliminary study
Int Pharmacopsychiatry
Overview of drug treatment in autism
Brief report: An open study of fenfluramine in hospitalized young autistic children
J Autism Dev Disord
The efficacy and safety of fenfluramine in autistic children: Preliminary analysis of a double-blind study
Psychopharmacol Bull
Fenfluramine and brain serotonin
Ann NY Acad Sci
Dopamine and serotonin metabolism in neurophyschiatric disturbed children: CSF homovanillic acid 5-hydroxyindoleacetic acid
Arch Gen Psychiatry
Biogenic amines in autistic and atypical children: Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid
Arch Gen Psychiatry
Serotonin in Down's Syndrome
The Biology of Autistic Syndromes
Cited by (84)
Autism spectrum disorder (ASD): Disturbance of the melatonin system and its implications
2020, Biomedicine and PharmacotherapyCitation Excerpt :Given that sleep disorders and low melatonin levels are frequently observed in ASD patients, melatonin signaling is anticipated to modulate the synaptic function and, thereby, the core symptom of ASD. A growing body of evidence has explored the potential effects of melatonin in experimental ASD models as brain dysfunction in the pineal hypothalamus-pituitary-adrenal (HPA) axis [39,138], indicating that reduced serine/threonine kinase signal transduction in ASD [44]. Melatonin restores the social interaction function of valproic acid (VPA)-treated rats, which associated with the elevated phosphorylation of CaMKII/PKC/PKA and restored LTP in hippocampus (Fig. 2).
The Theory of Endobiogeny: Volume 3: Advanced Concepts for the Treatment of Complex Clinical Conditions
2019, The Theory of Endobiogeny: Volume 3: Advanced Concepts for the Treatment of Complex Clinical ConditionsComplementary and Alternative Medicine Treatments for Children with Autism Spectrum Disorders
2015, Child and Adolescent Psychiatric Clinics of North AmericaSleep and Sleep Problems in Children with Neurologic Disorders
2012, Therapy in Sleep MedicineMelatonin for disordered sleep in individuals with autism spectrum disorders: Systematic review and discussion
2011, Sleep Medicine ReviewsCitation Excerpt :This search was conducted on all citations published until November 2010 regardless of the language used in the publications. Although melatonin use for sleep disturbance in individuals with ASD was first proposed by Chamberlain and Herman in 1990,38 the search started from 1958 because melatonin was first isolated in that year. The Cochrane Library and numerous textbooks were also reviewed to identify additional studies, and the document search was completed by a manual search of references.
Circadian rhythms and sleep in children with autism
2010, Neuroscience and Biobehavioral Reviews
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Supported in part by grants from NICHD-HD23330-01, Food and Drug Administrartion Orphan Drug Grant, March of Dimes Birth Defects Social and Behavioural Sciences Research Grant (12-235), the Stallone Fund for Autism Research, the Board of Lady Visitors of Children's National Medical Center, and the Adrianna Foundation (awarded to B.H.H.. R.S.C. is a recipient of a W.T. Gill Research felloship awarad from George Washington University School of Medicine and a fellowship from the Summer Science Research Programa for Medical Students Grant 8-88-48 from the March of Dimes Birth Defects Foundations.