Salivary levels of α2-macroglobulin, α1-antitrypsin, C-reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease

doi:10.1016/0003-9969(95)00089-5

Archives of Oral Biology

Volume 40, Issue 12, December 1995, Pages 1151-1155

https://doi.org/10.1016/0003-9969(95)00089-5 Get rights and content

Abstract

Five host-response indicators were measured by enzyme-linked immunosorbent assays on unstimulated whole saliva samples from 45 adults (19 male, 26 female). The participants were distributed among four dentate groups representing oral health (I), gingivitis (II), moderate periodontitis (III), and severe periodontitis (IV), and one group of edentulous volunteers (V). Levels of the host-response indicators varied widely, from zero, primarily with groups I and V, to relatively high values with groups II, III and IV. The levels ranged as follows: α₂-macroglobulin, 0–4941 ng/ml; α₁-antitrypsin, 2–2271 ng/ml; C-reactive protein, 0–472 pg/ml; cathepsin G, 0–6035 ng/ml; elastase, 0–164 ng/ml (free), 0–732 ng/ml (bound to α₁-antitrypsin), and 0–318 ng/ml (bound to α₂-macroglobulin). Statistical evaluation by planned contrasts showed that levels of host-response indicators for group I were significantly lower (except for α₁-antitrypsin) than for groups II, III, and IV. A trend analysis of groups I-IV showed that mean scores (again, except for α₁-antitrypsin) increased significantly in a positive, monotonic manner. Group V showed significantly lower values for elastase than in the other groups. The findings demonstrate that these factors can be detected in whole saliva and suggest that, except for α₁-antitrypsin, their levels are directly related to an individual's periodontal status.

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Short communicationSalivary levels of α2-macroglobulin, α1-antitrypsin, C-reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease

Abstract

Archs oral Biol.

Archs oral Biol.

J. immunol. Methods

The ability of gingival crevicular fluid acute phase proteins to distinguish healthy, gingivitis and periodontitis sites

J. clin. Periodontol.

Acute-phase proteins in gingival crevicular fluid during experimentally induced gingivitis

J. perio. Res.

Ratio of α1-antitrypsin to transferrin in gingival fluid and in blood from patients with periodontal disease

Scand. J. dent. Res.

Salivary enzymes

J. Am. dent. Assn.

Alpha-2-macroglobulin in sulci from healthy and inflamed human gingivae

Infect. Immun.

Markers of periodontal disease susceptibility and activity derived from gingival crevicular fluid: specific vs non-specific analyses

The identification of salivary components

Measurements of interleukin-6 in gingival crevicular fluid from adults with destructive periodontal disease

J. Periodont.

Neutrophil elastase and its inhibitors in human gingival crevicular fluid during experimental gingivitis

J. dent. Res.

Granulocyte elastase in gingival crevicular fluid. A possible discriminator between gingivitis and periodontitis

J. clin. Periodont.

Altered relations between granulocyte elastase and alpha-2macroglobulin in gingival crevicular fluid from sites with periodontal destruction

J. clin. Periodont.

Gingival crevicular fluid of patients with gingivitis or periodontal disease: evaluation of elastase-alpha-1 proteinase inhibitor complex

J. clin. Periodont.

Short communication
Salivary levels of α₂-macroglobulin, α₁-antitrypsin, C-reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease

Ratio of α₁-antitrypsin to transferrin in gingival fluid and in blood from patients with periodontal disease