Clinical studyRadiation heart disease: Analysis of 16 young (aged 15 to 33 years) necropsy patients who received over 3,500 rads to the heart
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2022, Advances in Cancer ResearchCitation Excerpt :The resulting inflammatory process drives an increase in myocardial cell death, which fosters the accumulation of reparative fibrous tissue with consequent ventricular stiffening and impaired elasticity and cardiac compliance (Taunk et al., 2015). Valvulopathy has been reported following RT, with more than 80% of patients who receive at least 35 Gy experiencing direct damage of the valve, including thickening, increased calcification, and leaflet fibrosis (Brosius, Waller, & Roberts, 1981; Taunk et al., 2015). Increased evidence of pericardial disease was experienced by almost 90% of the patients exposed to significant mediastinal radiation (Groarke et al., 2014).
Imaging of the Chest After Radiotherapy and Potential Pitfalls
2021, Seminars in Ultrasound, CT and MRICitation Excerpt :In addition to MRI's advantage of not using ionizing radiation and accurately showing a thickened pericardium27, MRI also shows septal flattening and diastolic bouncing characteristic of constrictive pericarditis, best seen in the 4-chamber cine steady-state free precession MR images, helpful in differentiating constrictive pericarditis from restrictive cardiomyopathy. RT can cause cardiomyopathy due to direct injury and myocardial fibrosis or ischemia.28 Radiation induced myocardial fibrosis can result in a broad spectrum of myocardial dysfunction most commonly resulting in restrictive cardiomyopathy.
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Present address: Department of Medicine, University of Michigan Medical Center, Ann Arbor, MI 48104.
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From the Pathology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.