Clinicial study

Mechanisms of QRS complex prolongation in man: Left ventricular conduction disturbances

Congestive heart failure (CHF) is a complex multistage syndrome that has a great financial burden on human societies. It was known that the damaged myocardium sends a signal to stimulate the immune system and proliferation of leukocytes. In continuous, cytokine storm can be initiated and causes the probability of CHF. Persistent inflammation by increasing the levels of pro-inflammatory cytokines, plays an important role in the pathogenesis of CHF and causes remodeling, which is a progressive processs. Although treatment by drugs can reduce mortality and partially control the symptoms of heart failure patients, but complications and mortality are still high. Therefore, other treatment options such as Cardiac Resynchronization Therapy (CRT) are necessary. Today, it is known that CRT can be an effective treatment for many patients with heart failure. CRT is novel, non-pharmacological, and device-based therapy that would be beneficial to know more about its performance in the management of heart failure. In this study, we have reviewed the immunological processes involved in heart failure and the effect of CRT in controlling of the cytokine storm.

The association between duration of QRS and myocardial reperfusion is not very well established. Our aim was to assess the relationship between measurements of QRS duration and myocardial blush grade (MBG) in patients with ST-elevation myocardial infarction (STEMI) who were treated with a primary percutaneous coronary intervention (PCI).

Between January 2016 and June 2017, 200 patients with STEMI who presented within 12 h of symptom onset and taken up for primary PCI were analyzed with electrocardiogram (ECG) before and after the procedure. Two study groups were then defined on the basis of microvascular perfusion: group A (MBG 0-1) and group B (MBG 2-3).

Group A had a total of 80 patients, and group B had 120 patients. The baseline characteristics were similar in the two groups. QRS duration was found to be longer in group A compared with group B at both the immediate ECG (95.5 ± 15.63 vs 80.87 ± 12.80 msec, p < 0.001, respectively) and at the 60th minute ECG (96.95 ± 16.2 vs 78.82 ± 12.08 msec, p < 0.001, respectively) post angioplasty. Significant difference was detected between the two groups post-angioplasty at both the immediate (10.99 ± 10.05 vs −6.64 ± 10.61 msec, p < 0.001) and the 60th minute (13.03 ± 11.64 vs −7.95 ± 11.11 msec, p < 0.001) ECG. Using receiver operator curve analysis, we found that QRS complex narrowing of 4.5 msec post angioplasty was the best cutoff value for predicting reperfusion.

QRS duration change post angioplasty is strongly correlated with the myocardial reperfusion in patients presenting with STEMI.

Heart failure is one of the major causes of death in the western world. Besides optimal medication cardiac resynchronization therapy (CRT) has been well established in multiple large trials to improve reverse remodeling, symptoms, hospitalizations, and mortality in well-selected patients with heart failure. A substantial proportion of CRT patients, however, do not sufficiently respond to the therapy. In this article, we will discuss several aspects of CRT including resynchronization in the failing heart, evidence of efficacy based on clinical trials, and current challenges including patient selection, lead positioning, multisite left ventricular pacing, and optimization of programming.

Prolongation of initial ventricular depolarization on the 12-lead electrocardiogram (ECG), or delayed intrinsicoid deflection (DID), can indicate left ventricular hypertrophy (LVH). The possibility that this marker could convey distinct risk of sudden cardiac arrest (SCA) has not been evaluated.

To evaluate the association of DID and SCA in the community.

In the ongoing prospective, population-based Oregon Sudden Unexpected Death Study (Oregon SUDS; catchment area approximately 1 million), SCA cases were compared to geographic controls with no SCA. Archived ECGs (closest and unrelated to SCA event for cases) were evaluated for the presence of DID, defined as ≥0.05 second in leads V₅ or V₆. Left ventricular (LV) mass and function were evaluated from archived echocardiograms.

SCA cases (n = 272, 68.7 ± 14.6 years, 63.6% male) as compared to controls (n = 351, 67.6 ± 11.4 years, 63.3% male) were more likely to have DID on ECG (28.3% vs 17.1%, P = .001). DID was associated with increased SCA odds (odds ratio [OR] 1.92; 95% confidence interval [CI] 1.31–2.81; P = .001), but showed poor correlation with LV mass and echocardiographic LVH (kappa 0.13). In multivariate analysis adjusted for clinical and ECG markers, reduced LV ejection fraction, and echocardiographic LVH, DID remained an independent predictor of SCA (OR 1.82; 95% CI 1.12–2.97; P = .016). Additionally, in a sensitivity analysis restricted to narrow QRS, DID and ECG LVH by voltage were each independently associated with SCA risk.

DID was associated with increased SCA risk independent of echocardiographic LVH, ECG LVH, and reduced LV ejection fraction, potentially reflecting unique electrical remodeling that warrants further investigation.