Comparison of Nifedipine gastrointestinal therapeutic system and Atenolol on antianginal efficacies and exercise hemodynamic responses in stable angina pectoris☆
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State of the art approach to managing angina and ischemia: tailoring treatment to the evidence
2021, European Journal of Internal MedicineCitation Excerpt :There are no convincing data proving that BB are more effective than other antianginal drugs to treat angina or to prolong total exercise duration. The studies quoted by the ESC CCS guideline task-force to support their preferential use had small sample sizes and short follow up periods [30, 31] (n=17 for 12 weeks, and n= 608 for 6 weeks), whereas in a meta-analysis used to support their argument, they were found no more effective than other anti-anginal agents (32). All studies were conducted before the combination of aspirin, statin and RAAS inhibitors became standard of care (4).
The ESC 2019 CCS guidelines: Have we left our patients and scientific evidence behind?
2020, European Journal of Internal MedicineCitation Excerpt :Finally, there is a metanalysis of 90 randomized or crossover studies which compared antianginal drugs from different classes (LAN, calcium antagonists and beta-blockers) showing equivalent effectiveness of all three classes in the treatment of stable angina [12]. Regarding the use of beta blockers for angina prophylaxis, the evidence for recommendation by the ESC guideline is based on two double-blind studies with 608 and 17 patients respectively while the follow up period was 6 and 12 weeks respectively [13,14]. The end-points were exercise parameters.
Stable angina pectoris
2017, Coronary Artery Disease: From Biology to Clinical PracticeManagement standards for stable coronary artery disease in India
2016, Indian Heart JournalCitation Excerpt :Beta-blockers have been compared to CCBs in numerous trials for the management of stable angina. With regard to the treatment efficacy against angina, beta-blockers and CCBs are found to be similar.75–77 Indeed, a couple of meta-analyses revealed that the CCBs and beta-blockers exert similar anti-anginal effects; nevertheless, beta-blockers were found to be associated with fewer adverse events than CCBs.73,78
Comparative efficacy of ranolazine versus atenolol for chronic angina pectoris
2005, American Journal of CardiologyCitation Excerpt :Although their quantitative effects on study end points were strikingly similar, ranolazine and atenolol produced the observed therapeutic effects through markedly divergent pharmacologic mechanisms. Atenolol therapy compared with placebo significantly decreased RPP at all time points during exercise, with greater effects at higher exercise loads, thus supporting the well-established consensus opinion that the therapeutic effects of atenolol are mediated through a decrease in cardiac work.5,7 In contrast, ranolazine therapy produced little or no effect on RPP at rest or at any point during exercise (Figure 3).
Expert consensus document on β-adrenergic receptor blockers
2005, Revista Espanola de Cardiologia
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This study was supported in part by a grant from Pfizer Laboratories, New York, New York.