Nonspecific electrocardiographic abnormality as a predictor of coronary heart disease: The Framingham Study☆
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2021, American Journal of Emergency MedicineCitation Excerpt :It is often most prominent in the left precordial leads V4–6 plus leads I, II and aVL. The prevalence of ST-T changes in the resting ECG in the Framingham study was found to be 8.5% in men and 7.7% in women and it was reported that the CAD-related morbidity and mortality increased twice in these cases [28]. Myocardial ischemia affects especially the repolarization phase due to intracellular low K + ion, during which action potential times are shortened and the repolarization pattern changes and ST-T changes occur [29].
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2017, American Heart JournalCitation Excerpt :A number of large cohort studies have identified associations between ECG abnormalities and future cardiovascular events. Framingham investigators reported ST/T wave abnormalities among 8.5% of men and 7.7% of women aged 44-74 years old,25 similar to the prevalence of major ST/T wave abnormalities (7.2%) in our population. With >30 years of follow-up, Framingham researchers identified an association between ST/T wave abnormalities and incident coronary disease independent of known cardiovascular risk factors.
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Supported by contract Nos. NIH-N01-HV-92922 and NIH-N01-HV-52971.