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Sex Differences in Autism Spectrum Disorders Across the Lifespan

  • Autism Spectrum (A Richdale and L Lawson, Section Editors)
  • Published:
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Abstract

Purpose of Review

This review aimed to examine contemporary findings on sex-related differences in autism spectrum disorder from pre-school to adulthood. By exploring the literature within developmental time points, it is possible to consider emerging lifespan patterns and determine consistency of results without the impact of developmental change.

Recent Findings

Findings continue to be varied due to numerous methodological differences across studies. However, some results are more consistent than others. For instance, while there is no evidence for a sex difference in cognition in early childhood, there may be executive functioning differences in adolescence/adulthood. Further males exhibit more and different restricted repetitive behaviours, while females have more motivation toward friendships and compensatory behaviours.

Summary

The results reviewed provide emerging evidence for a female behaviour phenotype of ASD. However, future research should include a non-autistic comparison sample and consider the impact of sample characterisation (e.g. age range and genotype).

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Association AP. Diagnostic and statistical manual of mental disorders (DSM-5®). Philadelphia: American Psychiatric Pub; 2013.

    Book  Google Scholar 

  2. Lotter V. Epidemiology of autistic conditions in young children. Soc Psychol. 1966;1(3):124–35. https://doi.org/10.1007/bf00584048.

    Article  Google Scholar 

  3. Wing L. Sex ratios in early childhood autism and related conditions. Psychiatry Res. 1981;5(2):129–37. https://doi.org/10.1016/0165-1781(81)90043-3.

    Article  CAS  PubMed  Google Scholar 

  4. Tsai LY, Beisler JM. The development of sex differences in infantile autism. Br J Psychiatry. 1983;142(4):373–8. https://doi.org/10.1192/bjp.142.4.373.

    Article  CAS  PubMed  Google Scholar 

  5. Whiteley P, Todd L, Carr K, Shattock P. Gender ratios in autism, Asperger syndrome and autism spectrum disorder. Autism Insights. 2010;2010(2):17–24.

    Article  Google Scholar 

  6. • Loomes R, Hull L, Mandy WPL. What is the male-to-female ratio in autism spectrum disorder? A systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry. 2017;56(6):466–74. https://doi.org/10.1016/j.jaac.2017.03.013. Recent meta-analysis of male to female ratio.

  7. • Rutherford M, McKenzie K, Johnson T, Catchpole C, O’Hare A, McClure I, et al. Gender ratio in a clinical population sample, age of diagnosis and duration of assessment in children and adults with autism spectrum disorder. Autism. 2016;20(5):628–34. https://doi.org/10.1177/1362361315617879. Highlights how the sex ratio may differ by age.

    Article  PubMed  Google Scholar 

  8. Kreiser NL, White SW. ASD in females: are we overstating the gender difference in diagnosis? Clin Child Fam Psychol Rev. 2014;17(1):67–84. https://doi.org/10.1007/s10567-013-0148-9.

    Article  PubMed  Google Scholar 

  9. Lord C, Rutter M, Couteur A. Autism diagnostic interview-revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord. 1994;24:659–85. https://doi.org/10.1007/bf02172145.

    Article  CAS  PubMed  Google Scholar 

  10. •• Beggiato A, Peyre H, Maruani A, Scheid I, Rastam M, Amsellem F, Gillberg CI, Leboyer M, Bourgeron T, Gillberg C, Delorme R Gender differences in autism spectrum disorders: divergence among specific core symptoms. Autism Res 2017. doi:https://doi.org/10.1002/aur.1715. Illustrates the potential sex bias that exists in curent diagnostic tools. 10, 689.

  11. Kopp S, Beckung E, Gillberg C. Developmental coordination disorder and other motor control problems in girls with autism spectrum disorder and/or attention-deficit/hyperactivity disorder. Res Dev Disabil. 2010;31(2):350–61. https://doi.org/10.1016/j.ridd.2009.09.017.

    Article  PubMed  Google Scholar 

  12. Lord C, Schopler E. Brief report: differences in sex ratios in autism as a function of measured intelligence. J Autism Dev Disord. 1985;15(2):185–93. https://doi.org/10.1007/bf01531604.

    Article  CAS  PubMed  Google Scholar 

  13. Lord C, Schopler E, Revicki D. Sex differences in autism. J Autism Dev Disord. 1982;12(4):317–30. https://doi.org/10.1007/bf01538320.

    Article  CAS  PubMed  Google Scholar 

  14. Tsai LY, Stewart MA, August G. Implication of sex differences in the familial transmission of infantile autism. J Autism Dev Disord. 1981;11(2):165–73. https://doi.org/10.1007/bf01531682.

    Article  CAS  PubMed  Google Scholar 

  15. Volkmar FR, Szatmari P, Sparrow SS. Sex differences in pervasive developmental disorders. J Autism Dev Disord. 1993;23(4):579–91. https://doi.org/10.1007/bf01046103.

    Article  CAS  PubMed  Google Scholar 

  16. McLennan JD, Lord C, Schopler E. Sex differences in higher functioning people with autism. J Autism Dev Disord. 1993;23(2):217–27. https://doi.org/10.1007/bf01046216.

    Article  CAS  PubMed  Google Scholar 

  17. Hartley SL, Sikora DM. Sex differences in autism spectrum disorder: an examination of developmental functioning, autistic symptoms, and coexisting behavior problems in toddlers. J Autism Dev Disord. 2009;39(12):1715–22. https://doi.org/10.1007/s10803-009-0810-8.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Sipes M, Matson JL, Worley JA, Kozlowski AM. Gender differences in symptoms of autism spectrum disorders in toddlers. Res Autism Spectr Disord. 2011;5(4):1465–70. https://doi.org/10.1016/j.rasd.2011.02.007.

    Article  Google Scholar 

  19. •• Messinger DS, Young GS, Webb SJ, Ozonoff S, Bryson SE, Carter A, et al. Early sex differences are not autism-specific: a Baby Siblings Research Consortium (BSRC) study. Mol Autism. 2015;6(1):32. https://doi.org/10.1186/s13229-015-0027-y. Provides evidence that sex differences in early childhood may not be autism specific.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Wang S, Deng H, You C, Chen K, Li J, Tang C, et al. Sex differences in diagnosis and clinical phenotypes of Chinese children with autism spectrum disorder. Neurosci Bull. 2017;33(2):153–60. https://doi.org/10.1007/s12264-017-0102-9.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Lawson LP, Joshi R, Barbaro J, Dissanayake C. Gender differences during toddlerhood in autism spectrum disorder: a prospective community-based longitudinal follow-up study. J Autism Dev Disord. 2018;48(8):2619–28. https://doi.org/10.1007/s10803-018-3516-y.

    Article  PubMed  Google Scholar 

  22. Westman-Andersson G, Gillberg C, Miniscalco C. Pre-school children with suspected autism spectrum disorders: do girls and boys have the same profiles? Res Dev Disabil. 2013;34(1):413–22. https://doi.org/10.1016/j.ridd.2012.08.025.

    Article  Google Scholar 

  23. Postorino V, Fatta LM, De Peppo L, Giovagnoli G, Armando M, Vicari S, et al. Longitudinal comparison between male and female preschool children with autism spectrum disorder. J Autism Dev Disord. 2015;45(7):2046–55. https://doi.org/10.1007/s10803-015-2366-0.

    Article  PubMed  Google Scholar 

  24. • Reinhardt VP, Wetherby AM, Schatschneider C, Lord C. Examination of sex differences in a large sample of young children with autism spectrum disorder and typical development. J Autism Dev Disord. 2015;45(3):697–706. https://doi.org/10.1007/s10803-014-2223-6. Large sample with non-autistic comparison sample.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Knutsen J, Crossman M, Perrin J, Shui A, Kuhlthau K. Sex differences in restricted repetitive behaviors and interests in children with autism spectrum disorder: an autism treatment network study. Autism. 2018;0(0):1362361318786490. https://doi.org/10.1177/1362361318786490.

    Article  Google Scholar 

  26. Matheis M, Matson JL, Hong E, Cervantes PE. Gender differences and similarities: autism symptomatology and developmental functioning in young children. J Autism Dev Disord. 2019;49(3):1219–31. https://doi.org/10.1007/s10803-018-3819-z.

    Article  PubMed  Google Scholar 

  27. Zwaigenbaum L, Bryson SE, Szatmari P, Brian J, Smith IM, Roberts W, et al. Sex differences in children with autism spectrum disorder identified within a high-risk infant cohort. J Autism Dev Disord. 2012;42(12):2585–96. https://doi.org/10.1007/s10803-012-1515-y.

    Article  PubMed  Google Scholar 

  28. Chawarska K, Macari S, Powell K, DiNicola L, Shic F. Enhanced social attention in female infant siblings at risk for autism. J Am Acad Child Adolesc Psychiatry. 2016;55(3):188–95.e1. https://doi.org/10.1016/j.jaac.2015.11.016.

    Article  PubMed  Google Scholar 

  29. Carter AS, Black DO, Tewani S, Connolly CE, Kadlec MB, Tager-Flusberg H. Sex differences in toddlers with autism spectrum disorders. J Autism Dev Disord. 2007;37(1):86–97. https://doi.org/10.1007/s10803-006-0331-7.

    Article  PubMed  Google Scholar 

  30. Sacrey L-AR, Zwaigenbaum L, Szatmari P, Bryson S, Georgiades S, Brian J, et al. Brief report: characteristics of preschool children with ASD vary by ascertainment. J Autism Dev Disord. 2017;47(5):1542–50. https://doi.org/10.1007/s10803-017-3062-z.

    Article  PubMed  Google Scholar 

  31. Kumazaki H, Muramatsu T, Kosaka H, Fujisawa TX, Iwata K, Tomoda A, et al. Sex differences in cognitive and symptom profiles in children with high functioning autism spectrum disorders. Res Autism Spectr Disord. 2015;13(14):1–7. https://doi.org/10.1016/j.rasd.2014.12.011.

    Article  Google Scholar 

  32. Hiller RM, Young RL, Weber N. Sex differences in autism spectrum disorder based on DSM-5 criteria: evidence from clinician and teacher reporting. J Abnorm Child Psychol. 2014;42(8):1381–93. https://doi.org/10.1007/s10802-014-9881-x.

    Article  PubMed  Google Scholar 

  33. Supekar K, Menon V. Sex differences in structural organization of motor systems and their dissociable links with repetitive/restricted behaviors in children with autism. Mol Autism. 2015;6(1):50. https://doi.org/10.1186/s13229-015-0042-z.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Sutherland R, Hodge A, Bruck S, Costley D, Klieve H. Parent-reported differences between school-aged girls and boys on the autism spectrum. Autism. 2017:1362361316668653;21:785–94. https://doi.org/10.1177/1362361316668653.

    Article  PubMed  Google Scholar 

  35. Nowell SW, Jones DR, Harrop C. Circumscribed interests in autism: are there sex differences? Advances in Autism. 2019. https://doi.org/10.1108/AIA-09-2018-0032.

  36. Rynkiewicz A, Schuller B, Marchi E, Piana S, Camurri A, Lassalle A, et al. An investigation of the ‘female camouflage effect’ in autism using a computerized ADOS-2 and a test of sex/gender differences. Mol Autism. 2016;7(1):10. https://doi.org/10.1186/s13229-016-0073-0.

    Article  PubMed  PubMed Central  Google Scholar 

  37. May T, Cornish K, Rinehart N. Does gender matter? A one year follow-up of autistic, attention and anxiety symptoms in high-functioning children with autism spectrum disorder. J Autism Dev Disord. 2014;44(5):1077–86. https://doi.org/10.1007/s10803-013-1964-y.

    Article  PubMed  Google Scholar 

  38. Evans SC, Boan AD, Bradley C, Carpenter LA. Sex/gender differences in screening for autism spectrum disorder: implications for evidence-based assessment. J Clin Child Adolesc Psychol 2018 https://doi.org/10.1080/15374416.2018.1437734.

  39. Lord C, Risi S, Lambrecht L, Cook EH, Leventhal BL, DiLavore PC, et al. The Autism Diagnostic Observation Schedule—generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord. 2000;30(3):205–23. https://doi.org/10.1023/a:1005592401947.

    Article  CAS  PubMed  Google Scholar 

  40. Lord C, Rutter M, Dilavore P, Risi S, Gotham K, Bishop S. Autism Diagnostic Observation Schedule. TorranceWestern: Psychological Services; 2012.

    Google Scholar 

  41. Amr M, Raddad D, El-Mehesh F, Mahmoud E-H, El-Gilany A-H. Sex differences in Arab children with autism spectrum disorders. Res Autism Spectr Disord. 2011;5(4):1343–50. https://doi.org/10.1016/j.rasd.2011.01.015.

    Article  Google Scholar 

  42. Harrop C, Jones D, Zheng S, Nowell SW, Boyd BA, Sasson N. Sex differences in social attention in autism spectrum disorder. Autism Res. 2018;11(9):1264–75. https://doi.org/10.1002/aur.1997.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Banach R, Thompson A, Szatmari P, Goldberg J, Tuff L, Zwaigenbaum L, et al. Brief report: relationship between non-verbal IQ and gender in autism. J Autism Dev Disord. 2009;39(1):188–93. https://doi.org/10.1007/s10803-008-0612-4.

    Article  PubMed  Google Scholar 

  44. Dworzynski K, Ronald A, Bolton P, Happé F. How different are girls and boys above and below the diagnostic threshold for autism spectrum disorders? J Am Acad Child Adolesc Psychiatry. 2012;51(8):788–97. https://doi.org/10.1016/j.jaac.2012.05.018.

    Article  PubMed  Google Scholar 

  45. Baron-Cohen S, Cassidy S, Auyeung B, Allison C, Achoukhi M, Robertson S, et al. Attenuation of typical sex differences in 800 adults with autism vs. 3,900 controls. PLoS One. 2014;9(7):e102251. https://doi.org/10.1371/journal.pone.0102251.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Grove R, Hoekstra RA, Wierda M, Begeer S. Exploring sex differences in autistic traits: a factor analytic study of adults with autism. Autism. 2017;21(6):760–768. https://doi.org/10.1177/1362361316667283.

  47. Lehnhardt F-G, Falter CM, Gawronski A, Pfeiffer K, Tepest R, Franklin J, et al. Sex-related cognitive profile in autism spectrum disorders diagnosed late in life: implications for the female autistic phenotype. J Autism Dev Disord. 2016;46(1):139–54. https://doi.org/10.1007/s10803-015-2558-7.

    Article  PubMed  Google Scholar 

  48. Lai M-C, Lombardo MV, Pasco G, Ruigrok ANV, Wheelwright SJ, Sadek SA, et al. A behavioral comparison of male and female adults with high functioning autism spectrum conditions. PLoS One. 2011;6(6):e20835. https://doi.org/10.1371/journal.pone.0020835.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. •• Lai M-C, Lombardo MV, Ruigrok AN, Chakrabarti B, Auyeung B, Szatmari P, et al. Quantifying and exploring camouflaging in men and women with autism. Autism. 2017;21:690–702. https://doi.org/10.1177/1362361316671012. One of the first studies to look at quantifying the measurement of camourflaging behaviour.

    Article  PubMed  Google Scholar 

  50. Stauder JEA, Cornet LJM, Ponds RWHM. The extreme male brain theory and gender role behaviour in persons with an autism spectrum condition. Res Autism Spectr Disord. 2011;5(3):1209–14. https://doi.org/10.1016/j.rasd.2011.01.008.

    Article  Google Scholar 

  51. Lai M-C, Lombardo MV, Ruigrok ANV, Chakrabarti B, Wheelwright SJ, Auyeung B, et al. Cognition in males and females with autism: similarities and differences. PLoS One. 2012;7(10):e47198. https://doi.org/10.1371/journal.pone.0047198.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Hull L, Petrides KV, Allison C, Smith P, Baron-Cohen S, Lai M-C, et al. “Putting on My Best Normal”: social camouflaging in adults with autism spectrum conditions. J Autism Dev Disord. 2017;47(8):2519–34. https://doi.org/10.1007/s10803-017-3166-5.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Ketelaars MP, In’t Velt A, Mol A, Swaab H, van Rijn S. Emotion recognition and alexithymia in high functioning females with autism spectrum disorder. Res Autism Spectr Disord. 2016;21:51–60. https://doi.org/10.1016/j.rasd.2015.09.006.

    Article  Google Scholar 

  54. Ketelaars MP, In’t Velt A, Mol A, Swaab H, Bodrij F, van Rijn S. Social attention and autism symptoms in high functioning women with autism spectrum disorders. Res Dev Disabil. 2017;64:78–86. https://doi.org/10.1016/j.ridd.2017.03.005.

    Article  PubMed  Google Scholar 

  55. Fulton AM, Paynter JM, Trembath D. Gender comparisons in children with ASD entering early intervention. Res Dev Disabil. 2017;68:27–34. https://doi.org/10.1016/j.ridd.2017.07.009.

    Article  PubMed  Google Scholar 

  56. Mullen EM. Mullen scales of early learning. MN: AGS Circle Pines; 1995.

    Google Scholar 

  57. Ryland HK, Hysing M, Posserud M-B, Gillberg C, Lundervold AJ. Autistic features in school age children: IQ and gender effects in a population-based cohort. Res Autism Spectr Disord. 2014;8(3):266–74. https://doi.org/10.1016/j.rasd.2013.12.001.

    Article  Google Scholar 

  58. Rohde MS, Georgescu AL, Vogeley K, Fimmers R, Falter-Wagner CM. Absence of sex differences in mental rotation performance in autism spectrum disorder. Autism. 2017;0(0):1362361317714991):855–65. https://doi.org/10.1177/1362361317714991.

    Article  Google Scholar 

  59. Abbott P, Happé FG, Charlton RA. Exploratory study of executive function abilities across the adult lifespan in individuals receiving an ASD diagnosis in adulthood. J Autism Dev Disord. 2018;48(12):4193–206. https://doi.org/10.1007/s10803-018-3675-x.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Sparrow SS, Balla DA, Cicchetti DV, Harrison PL, Doll EA. Vineland adaptive behavior scales. 1984.

  61. Achenbach TM, Edelbrock C. Child behavior checklist. Burlington (Vt) 1991;7.

  62. Carter A, Briggs-Gowan M. Manual of the infant-toddler social-emotional assessment. New Haven, CT: Yale University; 2000.

    Google Scholar 

  63. Begeer S, Ma Y, Koot HM, Wierda M, van Beijsterveldt CEM, Boomsma DI, et al. Brief report: influence of gender and age on parent reported subjective well-being in children with and without autism. Res Autism Spectr Disord. 2017;35:86–91. https://doi.org/10.1016/j.rasd.2016.11.004.

    Article  Google Scholar 

  64. Oswald TM, Winter-Messiers MA, Gibson B, Schmidt AM, Herr CM, Solomon M. Sex differences in internalizing problems during adolescence in autism spectrum disorder. J Autism Dev Disord. 2016;46(2):624–36. https://doi.org/10.1007/s10803-015-2608-1.

    Article  PubMed  Google Scholar 

  65. Achenbach TM, Edelbrock CS. Manual for the youth self-report and profile. University of Vermont: Department of Psychiatry; 1987.

    Google Scholar 

  66. • Pisula E, Pudło M, Słowińska M, Kawa R, Strząska M, Banasiak A, et al. Behavioral and emotional problems in high-functioning girls and boys with autism spectrum disorders: parents’ reports and adolescents’ self-reports. Autism. 2017;21:738–48. https://doi.org/10.1177/1362361316675119. Examines both self- and parent-report psychopathology and includes a non-autistic comparison sample.

    Article  PubMed  Google Scholar 

  67. Tsakanikos E, Underwood L, Kravariti E, Bouras N, McCarthy J. Gender differences in co-morbid psychopathology and clinical management in adults with autism spectrum disorders. Res Autism Spectr Disord. 2011;5(2):803–8. https://doi.org/10.1016/j.rasd.2010.09.009.

    Article  Google Scholar 

  68. Zahn-Waxler C, Shirtcliff EA, Marceau K. Disorders of childhood and adolescence: gender and psychopathology. Annu Rev Clin Psychol. 2008;4(1):275–303. https://doi.org/10.1146/annurev.clinpsy.3.022806.091358.

    Article  PubMed  Google Scholar 

  69. Dean M, Kasari C, Shih W, Frankel F, Whitney R, Landa R, et al. The peer relationships of girls with ASD at school: comparison to boys and girls with and without ASD. J Child Psychol Psychiatry. 2014;55(11):1218–25. https://doi.org/10.1111/jcpp.12242.

    Article  PubMed  Google Scholar 

  70. • Dean M, Harwood R, Kasari C. The art of camouflage: gender differences in the social behaviors of girls and boys with autism spectrum disorder. Autism. 2017;21(6):678–689. https://doi.org/10.1177/1362361316671845. Examines social behaviours and includes a non-autistic comparison sample.

  71. Tierney S, Burns J, Kilbey E. Looking behind the mask: social coping strategies of girls on the autistic spectrum. Res Autism Spectr Disord. 2016;23:73–83. https://doi.org/10.1016/j.rasd.2015.11.013.

    Article  Google Scholar 

  72. Vine Foggo RS, Webster AA. Understanding the social experiences of adolescent females on the autism spectrum. Res Autism Spectr Disord. 2017;35:74–85. https://doi.org/10.1016/j.rasd.2016.11.006.

    Article  Google Scholar 

  73. Sedgewick F, Hill V, Yates R, Pickering L, Pellicano E. Gender differences in the social motivation and friendship experiences of autistic and non-autistic adolescents. J Autism Dev Disord. 2016;46(4):1297–306. https://doi.org/10.1007/s10803-015-2669-1.

    Article  PubMed  Google Scholar 

  74. Sedgewick F, Hill V, Pellicano E. ‘It’s different for girls’: gender differences in the friendships and conflict of autistic and neurotypical adolescents. Autism. 2018. https://doi.org/10.1177/1362361318794930

  75. Baron-Cohen S, Wheelwright S. The Friendship Questionnaire: an investigation of adults with Asperger syndrome or high-functioning autism, and normal sex differences. J Autism Dev Disord. 2003;33(5):509–17. https://doi.org/10.1023/A:1025879411971.

    Article  PubMed  Google Scholar 

  76. Head AM, McGillivray JA, Stokes MA. Gender differences in emotionality and sociability in children with autism spectrum disorders. Mol Autism. 2014;5(1):19. https://doi.org/10.1186/2040-2392-5-19.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Kuo MH, Orsmond GI, Cohn ES, Coster WJ. Friendship characteristics and activity patterns of adolescents with an autism spectrum disorder. Autism. 2013;17(4):481–500. https://doi.org/10.1177/1362361311416380.

    Article  PubMed  Google Scholar 

  78. Rivet TT, Matson JL. Review of gender differences in core symptomatology in autism spectrum disorders. Res Autism Spectr Disord. 2011;5(3):957–76. https://doi.org/10.1016/j.rasd.2010.12.003.

    Article  Google Scholar 

  79. •• Hull L, Mandy W, Petrides K. Behavioural and cognitive sex/gender differences in autism spectrum condition and typically developing males and females. Autism. 2016;21:706–27. https://doi.org/10.1177/1362361316669087. Meta-analysis of results highlighting the importance of a non-autistic control sample.

    Article  PubMed  Google Scholar 

  80. Van Wijngaarden-Cremers PJM, van Eeten E, Groen WB, Van Deurzen PA, Oosterling IJ, Van der Gaag RJ. Gender and age differences in the core triad of impairments in autism spectrum disorders: a systematic review and meta-analysis. J Autism Dev Disord. 2014;44(3):627–35. https://doi.org/10.1007/s10803-013-1913-9.

    Article  PubMed  Google Scholar 

  81. Dickerson AS, Rotem RS, Christian MA, Nguyen VT, Specht AJ. Potential sex differences relative to autism spectrum disorder and metals. Curr Environ Health Rep. 2017;4(4):405–14. https://doi.org/10.1007/s40572-017-0164-x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. McCarthy MM, Wright CL. Convergence of sex differences and the neuroimmune system in autism spectrum disorder. Biol Psychiatry. 2017;81(5):402–10. https://doi.org/10.1016/j.biopsych.2016.10.004.

    Article  CAS  PubMed  Google Scholar 

  83. Schaafsma SM, Pfaff DW. Etiologies underlying sex differences in autism spectrum disorders. Front Neuroendocrinol. 2014;35(3):255–71. https://doi.org/10.1016/j.yfrne.2014.03.006.

    Article  PubMed  Google Scholar 

  84. Werling DM, Geschwind DH. Sex differences in autism spectrum disorders. Curr Opin Neurol. 2013;26(2):146–53. https://doi.org/10.1097/WCO.0b013e32835ee548.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Loke H, Harley V, Lee J. Biological factors underlying sex differences in neurological disorders. Int J Biochem Cell Biol. 2015;65:139–50. https://doi.org/10.1016/j.biocel.2015.05.024.

    Article  CAS  PubMed  Google Scholar 

  86. Berenbaum SA, Beltz AM. How early hormones shape gender development. Curr Opin Behav Sci. 2016;7:53–60. https://doi.org/10.1016/j.cobeha.2015.11.011.

    Article  PubMed  PubMed Central  Google Scholar 

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  1. Olga Tennison Autism Research Centre, La Trobe University, Plenty Road & Kingsbury Drive, Melbourne, VIC, 3086, Australia

    Lauren P. Lawson

  2. Cooperative Research Centre for Living with Autism (Autism CRC), Brisbane, Australia

    Lauren P. Lawson

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Lawson, L.P. Sex Differences in Autism Spectrum Disorders Across the Lifespan. Curr Dev Disord Rep 6, 57–66 (2019). https://doi.org/10.1007/s40474-019-00164-y

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