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Personalizing the Treatment of Pediatric Obsessive-Compulsive Disorder: Evidence for Predictors and Moderators of Treatment Outcomes

  • Child and Developmental Psychiatry (M Grados, Section Editor)
  • Published:
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Abstract

Cognitive behavioral therapy (CBT), delivered alone or with a serotonin reuptake inhibitor (SRI), is efficacious for treating pediatric obsessive-compulsive disorder (OCD), but not all youth respond optimally. Research to understand for whom a given intervention is beneficial can inform efforts to personalize treatment or tailor it to specific youths to enhance outcomes. We review studies that examined potential predictors/moderators of response to CBT, medication, and multimodal treatment for pediatric OCD: demographics, disorder-specific characteristics, general illness characteristics, neuropsychological functioning, biomarkers, family factors, and non-specific therapy factors. Methodological differences across studies make it challenging to synthesize findings and more research with large samples is needed. However, family factors have emerged as relatively consistent and strong predictors of treatment outcomes and there is preliminary support for attention to the presence of tics in treatment selection. There is little evidence for age and other demographic differences in treatment response.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Rapoport JL, Inoff-Germain G. Practitioner review: treatment of obsessive-compulsive disorder in children and adolescents. J Child Psychol Psyc. 2000;41(4):419–31.

    Article  CAS  Google Scholar 

  2. Rufer M, Hand I, Alsleben H, et al. Long-term course and outcome of obsessive-compulsive patients after cognitive-behavioral therapy in combination with either fluvoxamine or placebo: a 7-year follow-up of a randomized double-blind trial. Eur Arch Psychiatry Clin Neurosci. 2005;255(2):121–8.

    Article  PubMed  Google Scholar 

  3. Piacentini J, Peris TS, Bergman RL, Chang S, Jaffer M. Functional impairment in childhood OCD: development and psychometrics properties of the Child Obsessive-Compulsive Impact Scale-Revised (COIS-R). J Clin Child Adolesc Psychol. 2007;36(4):645–53.

    Article  PubMed  Google Scholar 

  4. Geller DA, March J, Walter HJ, et al. Practice parameter for the assessment and treatment of children and adolescents with obsessive-compulsive disorder. J Am Acad Child Psy. 2012;51(1):98–113.

    Article  Google Scholar 

  5. Pediatric OCD Treatment Study (POTS) Team. Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive-compulsive disorder: the Pediatric OCD Treatment Study (POTS) randomized controlled trial. JAMA. 2004;292(16):1969–76.

    Article  Google Scholar 

  6. Kraemer HC, Wilson GT, Fairburn CG, Agras WS. Mediators and moderators of treatment effects in randomized clinical trials. Arch Gen Psychiatry. 2002;59(10):877–83.

    Article  PubMed  Google Scholar 

  7. U.S. Department of Health and Human Services NIoH, National Institute of Mental Health. NIMH Strategic Plan for Research (NIH Publication No. 02–2650). 2015.

  8. Geller DA, Biederman J, Jones J, Shapiro S, Schwartz S, Park KS. Obsessive-compulsive disorder in children and adolescents: a review. Harv Rev Psychiatry. 1998;5(5):260–73.

    Article  CAS  PubMed  Google Scholar 

  9. Geller DA, Biederman J, Faraone SV, et al. Disentangling chronological age from age of onset in children and adolescents with obsessive-compulsive disorder. Int J Neuropsychopharmacol. 2001;4(2):169–78.

    Article  CAS  PubMed  Google Scholar 

  10. Drysdale AT, Hartley CA, Pattwell SS, et al. Fear and anxiety from principle to practice: implications for when to treat youth with anxiety disorders. Biol Psychiatry. 2014;75(11):e19–20.

    Article  PubMed Central  PubMed  Google Scholar 

  11. Pattwell SS, Duhoux S, Hartley CA, et al. Altered fear learning across development in both mouse and human. Proceedings Nat Acad Sci. 2012;109(40):16318–23.

    Article  CAS  Google Scholar 

  12. Pattwell SS, Lee FS, Casey BJ. Fear learning and memory across adolescent development: hormones and behavior special issue: puberty and adolescence. Horm Behav. 2013;64(2):380–9.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Rudy BM, Lewin AB, Geffken GR, Murphy TK, Storch EA. Predictors of treatment response to intensive cognitive-behavioral therapy for pediatric obsessive-compulsive disorder. Psychiatry Res. 2014;220(1–2):433–40.

    Article  PubMed  Google Scholar 

  14. Benazon NR, Ager J, Rosenberg DR. Cognitive behavior therapy in treatment-naive children and adolescents with obsessive-compulsive disorder: an open trial. Behav Res Ther. 2002;40(5):529–39.

    Article  CAS  PubMed  Google Scholar 

  15. Olino TM, Gillo S, Rowe D, et al. Evidence for successful implementation of exposure and response prevention in a naturalistic group format for pediatric OCD. Depress Anxiety. 2011;28(4):342–8.

    Article  PubMed Central  PubMed  Google Scholar 

  16. Piacentini J, Bergman RL, Jacobs C, McCracken JT, Kretchman J. Open trial of cognitive behavior therapy for childhood obsessive-compulsive disorder. J Anxiety Disord. 2002;16(2):207–19.

    Article  PubMed  Google Scholar 

  17. Torp NC, Dahl K, Skarphedinsson G, et al. Predictors associated with improved cognitive-behavioral therapy outcome in pediatric obsessive-compulsive disorder. J Am Acad Child Psy. 2015;54(3):200–207 e201. This study examined 20 potential predictors of OCD severity following CBT in a large sample of youth, and identified high impact of comorbid symptoms on OCD treatment outcome.

    Article  Google Scholar 

  18. Flament MF, Rapoport JL, Berg CJ, et al. Clomipramine treatment of childhood obsessive-compulsive disorder. A double-blind controlled study. Arch Gen Psychiatry. 1985;42(10):977–83.

    Article  CAS  PubMed  Google Scholar 

  19. Leonard HL, Rapoport JL. Pharmacotherapy of childhood obsessive-compulsive disorder. Psychiatr Clin North Am. 1989;12(4):963–70.

    CAS  PubMed  Google Scholar 

  20. March JS, Biederman J, Wolkow R, et al. Sertraline in children and adolescents with obsessive-compulsive disorder: a multicenter randomized controlled trial. JAMA. 1998;280(20):1752–6.

    Article  CAS  PubMed  Google Scholar 

  21. Geller DA, Wagner KD, Emslie G, et al. Paroxetine treatment in children and adolescents with obsessive-compulsive disorder: a randomized, multicenter, double-blind, placebo-controlled trial. J Am Acad Child Psy. 2004;43(11):1387–96.

    Article  Google Scholar 

  22. Thomsen PH. Child and adolescent obsessive-compulsive disorder treated with citalopram: findings from an open trial of 23 cases. J Child Adolesc Psychopharmacol. 1997;7(3):157–66.

    Article  CAS  PubMed  Google Scholar 

  23. Thomsen PH, Ebbesen C, Persson C. Long-term experience with citalopram in the treatment of adolescent OCD. J Am Acad Child Psy. 2001;40(8):895–902.

    Article  CAS  Google Scholar 

  24. Rosenberg DR, Stewart CM, Fitzgerald KD, Tawile V, Carroll E. Paroxetine open-label treatment of pediatric outpatients with obsessive-compulsive disorder. J Am Acad Child Psy. 1999;38(9):1180–5.

    Article  CAS  Google Scholar 

  25. Yaryura-Tobias JA, Grunes MS, Walz J, Neziroglu F. Parental obsessive-compulsive disorder as a prognostic factor in a year long fluvoxamine treatment in childhood and adolescent obsessive-compulsive disorder. Int Clin Psychopharmacol. 2000;15(3):163–8.

    Article  CAS  PubMed  Google Scholar 

  26. Masi G, Millepiedi S, Mucci M, Bertini N, Milantoni L, Arcangeli F. A naturalistic study of referred children and adolescents with obsessive-compulsive disorder. J Am Acad Child Psy. 2005;44(7):673–81.

    Article  Google Scholar 

  27. Garcia AM, Sapyta JJ, Moore PS, et al. Predictors and moderators of treatment outcome in the Pediatric Obsessive-Compulsive Treatment Study (POTS I). J Am Acad Child Psy. 2010;49(10):1024–33.

    Article  Google Scholar 

  28. Wever C, Rey JM. Juvenile obsessive-compulsive disorder. Aust NZ J Psychiatry. 1997;31(1):105–13.

    Article  CAS  Google Scholar 

  29. Barrett P, Healy-Farrell L, March JS. Cognitive-behavioral family treatment of childhood obsessive-compulsive disorder: a controlled trial. J Am Acad Child Psy. 2004;43(1):46–62.

    Article  Google Scholar 

  30. Bolton D, Luckie M, Steinberg D. Long-term course of obsessive-compulsive disorder treated in adolescence. J Am Acad Child Psy. 1995;34(11):1441–50.

    Article  CAS  Google Scholar 

  31. Riddle MA, Reeve EA, Yaryura-Tobias JA, et al. Fluvoxamine for children and adolescents with obsessive-compulsive disorder: a randomized, controlled, multicenter trial. J Am Acad Child Psy. 2001;40(2):222–229.

  32. Wagner KD, Cook EH, Chung H, Messig M. Remission status after long-term sertraline treatment of pediatric obsessive-compulsive disorder. J Child Adolesc Psychopharmacol. 2003;13 Suppl 1:S53–60.

    Article  PubMed  Google Scholar 

  33. Geller DA, Hoog SL, Heiligenstein JH, et al. Fluoxetine treatment for obsessive-compulsive disorder in children and adolescents: a placebo-controlled clinical trial. J Am Acad Child Psy. 2001;40(7):773–9.

    Article  CAS  Google Scholar 

  34. Masi G, Millepiedi S, Perugi G, et al. Pharmacotherapy in paediatric obsessive-compulsive disorder: a naturalistic, retrospective study. CNS Drugs. 2009;23(3):241–52.

    Article  CAS  PubMed  Google Scholar 

  35. Storch EA, Merlo LJ, Larson MJ, et al. Clinical features associated with treatment-resistant pediatric obsessive-compulsive disorder. Compr Psychiatry. 2008;49(1):35–42.

    Article  PubMed  Google Scholar 

  36. Leonard HL, Swedo SE, Lenane MC, et al. A 2-year to 7-year follow-up study of 54 obsessive-compulsive children and adolescents. Arch of Gen Psychiatry. 1993;50(6):429–39.

    Article  CAS  Google Scholar 

  37. Scahill L, Riddle MA, McSwiggin-Hardin M, et al. Children’s Yale-Brown Obsessive-Compulsive Scale: reliability and validity. J Am Acad Child Psy. 1997;36(6):844–52.

    Article  CAS  Google Scholar 

  38. Masi G, Pfanner C, Millepiedi S, Berloffa S. Aripiprazole augmentation in 39 adolescents with medication-resistant obsessive-compulsive disorder. J Clin Psychopharmacol. 2010;30(6):688–93.

    Article  CAS  PubMed  Google Scholar 

  39. Masi G, Pfanner C, Brovedani P. Antipsychotic augmentation of selective serotonin reuptake inhibitors in resistant tic-related obsessive-compulsive disorder in children and adolescents: a naturalistic comparative study. J Psychiatr Res. 2013;47(8):1007–12.

    Article  PubMed  Google Scholar 

  40. Mancebo MC, Boisseau CL, Garnaat SL, et al. Long-term course of pediatric obsessive-compulsive disorder: 3 years of prospective follow-up. Compr Psychiatry. 2014;55(7):1498–504.

    Article  PubMed Central  PubMed  Google Scholar 

  41. Storch EA, Milsom VA, Merlo LJ, et al. Insight in pediatric obsessive-compulsive disorder: associations with clinical presentation. Psychiatry Res. 2008;160(2):212–20.

    Article  PubMed  Google Scholar 

  42. Nakatani E, Krebs G, Micali N, Turner C, Heyman I, Mataix-Cols D. Children with very early onset obsessive-compulsive disorder: clinical features and treatment outcome. J Child Psychol Psychiatry. 2011;52(12):1261–8.

    Article  PubMed  Google Scholar 

  43. Storch EA, Murphy TK, Geffken GR, et al. Factor analytic study of the Children’s Yale–Brown Obsessive–Compulsive Scale. J of Clin Child Adolesc. 2005;34(2):312–9.

    Article  Google Scholar 

  44. Storch EA, Merlo LJ, Larson MJ, et al. Symptom dimensions and cognitive‐behavioural therapy outcome for pediatric obsessive‐compulsive disorder. Acta Psychiatr Scand. 2008;117(1):67–75.

    CAS  PubMed  Google Scholar 

  45. Iervolino AC, Rijsdijk FV, Cherkas L, Fullana MA, Mataix-Cols D. A multivariate twin study of obsessive-compulsive symptom dimensions. Arch Gen Psychiatry. 2011;68(6):637–44.

    Article  PubMed  Google Scholar 

  46. Storch EA, Merlo LJ, Larson MJ, et al. Impact of comorbidity on cognitive-behavioral therapy response in pediatric obsessive-compulsive disorder. J Am Acad Child Psy. 2008;47(5):583–92.

    Article  Google Scholar 

  47. McGuire JF, Piacentini J, Lewin AB, Brennan EA, Murphy TK, Storch EA. A meta-analysis of cognitive behavior therapy and medication for child obsessive-compulsive disorder: moderators of treatment efficacy, response, and remission. Depress Anxiety. 2015;32(8):580–93. This meta-analysis of 20 RCTs that sampled youth with OCD found large effects of CBT and moderate effects of SRI medication relative to comparison conditions, and identified several moderators of treatment outcomes.

    Article  CAS  PubMed  Google Scholar 

  48. Farrell L, Waters A, Milliner E, Ollendick T. Comorbidity and treatment response in pediatric obsessive-compulsive disorder: a pilot study of group cognitive-behavioral treatment. Psychiatry Res. 2012;199(2):115–23.

    Article  PubMed  Google Scholar 

  49. Achenbach TM, Rescorla L. ASEBA school-age forms and profiles. Aseba: Burlington; 2001.

  50. Murray K, Jassi A, Mataix-Cols D, Barrow F, Krebs G. Outcomes of cognitive behaviour therapy for obsessive-compulsive disorder in young people with and without autism spectrum disorders: a case controlled study. Psychiatry Res. 2015;228(1):8–13.

    Article  PubMed  Google Scholar 

  51. Brown HM, Lester KJ, Jassi A, Heyman I, Krebs G. Paediatric obsessive-compulsive disorder and depressive symptoms: clinical correlates and CBT treatment outcomes. J Abnorm Child Psychol. 2015;43(5):933–42.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  52. Meyer JM, McNamara JP, Reid AM, et al. Prospective relationship between obsessive-compulsive and depressive symptoms during multimodal treatment in pediatric obsessive-compulsive disorder. Child Psychiatry Hum Dev. 2014;45(2):163–72.

    Article  PubMed  Google Scholar 

  53. Leonard RC, Jacobi DM, Riemann BC, Lake PM, Luhn R. The effect of depression symptom severity on OCD treatment outcome in an adolescent residential sample. J Obsessive Compuls Relat Disord. 2014;3(2):95–101.

    Article  Google Scholar 

  54. Krebs G, Bolhuis K, Heyman I, Mataix‐Cols D, Turner C, Stringaris A. Temper outbursts in paediatric obsessive‐compulsive disorder and their association with depressed mood and treatment outcome. J Child Psychol Psyc. 2013;54(3):313–22.

    Article  Google Scholar 

  55. McGuire JF, Small BJ, Lewin AB, et al. Dysregulation in pediatric obsessive-compulsive disorder. Psychiatry Res. 2013;209(3):589–95.

    Article  PubMed  Google Scholar 

  56. Himle JA, Fischer DJ, Van Etten ML, Janeck AS, Hanna GL. Group behavioral therapy for adolescents with tic-related and non-tic-related obsessive-compulsive disorder. Depress Anxiety. 2003;17(2):73–7.

    Article  PubMed  Google Scholar 

  57. Geller DA, Biederman J, Stewart SE, et al. Impact of comorbidity on treatment response to paroxetine in pediatric obsessive-compulsive disorder: is the use of exclusion criteria empirically supported in randomized clinical trials? J Child Adol Psychop. 2003;13(2, Supplement 1):19–29.

    Article  Google Scholar 

  58. March JS, Franklin ME, Leonard H, et al. Tics moderate treatment outcome with sertraline but not cognitive-behavior therapy in pediatric obsessive-compulsive disorder. Biol Psychiatry. 2007;61(3):344–7.

    Article  PubMed  Google Scholar 

  59. Franklin ME, Sapyta J, Freeman JB, et al. Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorder: the Pediatric OCD Treatment Study II (POTS II) randomized controlled trial. JAMA. 2011;306(11):1224–32.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  60. Conelea CA, Walther MR, Freeman JB, et al. Tic-related obsessive-compulsive disorder (OCD): phenomenology and treatment outcome in the Pediatric OCD Treatment Study II. J Am Acad Child Psy. 2014;53(12):1308–16. Tic-related OCD was not associated with differential response to treatments (medication management alone, with CBT, or with CBT “instructions”) delivered to youth who were SRI partial responders.

    Article  Google Scholar 

  61. Skarphedinsson G, Compton S, Thomsen PH, et al. Tics moderate sertraline, but not cognitive-behavior therapy response in pediatric obsessive-compulsive disorder patients who do not respond to cognitive-behavior therapy. J Child Adolesc Psychopharmacol. 2015;25(5):432–9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  62. Hanna GL, Carrasco M, Harbin SM, et al. Error-related negativity and tic history in pediatric obsessive-compulsive disorder. J Am Acad Child Psy. 2012;51(9):902–10.

    Article  Google Scholar 

  63. Ivarsson T, Skarphedinsson G. Sleep problems and cognitive behavior therapy in pediatric obsessive-compulsive disorder have bidirectional effects. J Anxiety Disord. 2015;30:28–33.

    Article  PubMed  Google Scholar 

  64. Storch EA, Murphy TK, Lack CW, Geffken GR, Jacob ML, Goodman WK. Sleep-related problems in pediatric obsessive-compulsive disorder. J Anxiety Disord. 2008;22(5):877–85.

    Article  PubMed Central  PubMed  Google Scholar 

  65. Baum KT, Desai A, Field J, Miller LE, Rausch J, Beebe DW. Sleep restriction worsens mood and emotion regulation in adolescents. J Child Psychol Psyc. 2014;55(2):180–90.

    Article  Google Scholar 

  66. Hasler BP, Dahl RE, Holm SM, et al. Weekend-weekday advances in sleep timing are associated with altered reward-related brain function in healthy adolescents. Biol Psychol. 2012;91(3):334–41.

    Article  PubMed Central  PubMed  Google Scholar 

  67. Meyers JE, Meyers KR. Rey Complex Figure Test and Recognition Trial: supplemental norms for children and adults. Psychological Assessment Resources; 1996.

  68. Flessner CA, Allgair A, Garcia A, et al. The impact of neuropsychological functioning on treatment outcome in pediatric obsessive-compulsive disorder. Depress Anxiety. 2010;27(4):365–71.

    Article  PubMed  Google Scholar 

  69. Gioia GA, Isquith PK, Guy SC, Kenworthy L. Behavior Rating Inventory of Executive Function: BRIEF. FL: Psychological Assessment Resources Odessa; 2000.

    Google Scholar 

  70. McNamara JP, Reid AM, Balkhi AM, et al. Self-regulation and other executive functions relationship to pediatric OCD severity and treatment outcome. J Psychopathol Behav. 2014;36(3):432–42.

    Article  Google Scholar 

  71. Rosenberg DR, Keshavan MS. Toward a neurodevelopmental model of obsessive-compulsive disorder. Biol Psychiatry. 1998;43:623–40.

    Article  CAS  PubMed  Google Scholar 

  72. O’Neill J, Piacentini JC, Chang S, et al. MRSI correlates of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2012;36(1):161–8. Consistent with the glutamatergic hypothesis of OCD, this pilot study used imaging to identify metabolites that may indicate pediatric OCD and predict its response to CBT.

    Article  PubMed Central  PubMed  Google Scholar 

  73. Storch EA, Geffken GR, Merlo LJ, et al. Family accommodation in pediatric obsessive-compulsive disorder. J Clin Child Adolesc Psychol. 2007;36(2):207–16.

    Article  PubMed  Google Scholar 

  74. Merlo LJ, Lehmkuhl HD, Geffken GR, Storch EA. Decreased family accommodation associated with improved therapy outcome in pediatric obsessive-compulsive disorder. J Consult Clin Psychol. 2009;77(2):355–60.

    Article  PubMed Central  PubMed  Google Scholar 

  75. Piacentini J, Bergman RL, Chang S, et al. Controlled comparison of family cognitive behavioral therapy and psychoeducation/relaxation training for child obsessive-compulsive disorder. J Am Acad Child Psy. 2011;50(11):1149–61.

    Article  Google Scholar 

  76. Vaughn C, Leff J. Expressed emotion in families: its significance for mental illness. New York: Guilford; 1985.

    Google Scholar 

  77. Peris TS, Yadegar M, Asarnow JR, Piacentini J. Pediatric obsessive-compulsive disorder: family climate as a predictor of outcome. J Obsessive-Compulsive Rel Disord. 2012;1:267–73.

    Article  Google Scholar 

  78. Przeworski A, Zoellner LA, Franklin ME, et al. Maternal and child expressed emotion as predictors of treatment response in pediatric obsessive-compulsive disorder. Child Psychiatry Hum Dev. 2012;43(3):337–53.

    Article  PubMed Central  PubMed  Google Scholar 

  79. Peris TS, Miklowitz DJ. Parental expressed emotion and youth psychopathology: new directions for an old construct. Child Psychiatry Hum Dev. 2015;46(6):863–73.

    Article  PubMed Central  PubMed  Google Scholar 

  80. Diagnostic and statistical manual of mental disorders: DSM-III-R. Washington, DC: American Psychiatric Association, 1987.

  81. Epstein N, Baldwin L, Bishop D. The McMaster Family Assessment Device. J Marital Fam Ther. 1983;9(2):171–80.

    Article  Google Scholar 

  82. Insel TR, Hoover C, Murphy DL. Parents of patients with obsessive-compulsive disorder. Psychol Med. 1983;13:807–11.

    Article  CAS  PubMed  Google Scholar 

  83. Barrett P, Farrell L, Dadds M, Boulter N. Cognitive-behavioral family treatment of childhood obsessive-compulsive disorder: long-term follow-up and predictors of outcome. J Am Acad Child Psy. 2005;44(10):1005–14.

    Article  Google Scholar 

  84. Peris TS, Sugar CA, Bergman RL, Chang S, Langley A, Piacentini J. Family factors predict treatment outcome for pediatric obsessive-compulsive disorder. J Consult Clin Psychol. 2012;80(2):255–63. This study identified family conflict, parental blame, and poor family cohesion as strong predictors of treatment outcomes for youth randomized to family-focused CBT for OCD.

    Article  PubMed Central  PubMed  Google Scholar 

  85. Skinner HA, Steinhauer PD, Santa-Barbara J. FAM-III: Family Assessment Measure III. Multi-Health Systems; 1995.

  86. Rey JM, Singh M, Hung S, et al. A global scale to measure the quality of the family environment. Arch Gen Psychiatry. 1997;54(9):817–22.

    Article  CAS  PubMed  Google Scholar 

  87. Keeley ML, Geffken GR, Ricketts E, McNamara JP, Storch EA. The therapeutic alliance in the cognitive behavioral treatment of pediatric obsessive-compulsive disorder. J Anxiety Disord. 2011;25(7):855–63.

    Article  PubMed  Google Scholar 

  88. Lewin AB, Peris TS, Lindsey Bergman R, McCracken JT, Piacentini J. The role of treatment expectancy in youth receiving exposure-based CBT for obsessive-compulsive disorder. Behav Res Ther. 2011;49(9):536–43.

    Article  PubMed Central  PubMed  Google Scholar 

  89. Park JM, Small BJ, Geller DA, Murphy TK, Lewin AB, Storch EA. Does d-cycloserine augmentation of CBT improve therapeutic homework compliance for pediatric obsessive-compulsive disorder? J Child Fam Stud. 2014;23(5):863–71.

    Article  PubMed Central  PubMed  Google Scholar 

  90. Foa EB, Kozak MJ. Emotional processing of fear: exposure to corrective information. Psychol Bull. 1986;99(1):20–35.

    Article  CAS  PubMed  Google Scholar 

  91. Craske MG, Kircanski K, Zelikowsky M, Mystkowski J, Chowdhury N, Baker A. Optimizing inhibitory learning during exposure therapy. Behav Res Ther. 2008;46(1):5–27.

    Article  PubMed  Google Scholar 

  92. Kircanski K, Peris TS. Exposure and response prevention process predicts treatment outcome in youth with OCD. J Abnorm Child Psychol. 2015;43(3):543–52.

    Article  PubMed  Google Scholar 

  93. Ginsburg GS, Kingery JN, Drake KL, Grados MA. Predictors of treatment response in pediatric obsessive-compulsive disorder. J Am Acad Child Psy. 2008;47(8):868–78.

    Article  Google Scholar 

  94. Keeley ML, Storch EA, Merlo LJ, Geffken GR. Clinical predictors of response to cognitive-behavioral therapy for obsessive-compulsive disorder. Clin Psychol Rev. 2008;28(1):118–30.

    Article  PubMed  Google Scholar 

  95. Storch EA, Lewin AB, DeNadai AS, Murphy TK. Defining treatment response and remission in obsessive-compulsive disorder: a signal detection analysis of the Children’s Yale-Brown Obsessive-Compulsive Scale. J Am Acad Child Psy. 2010;49(7):708–17.

    Google Scholar 

  96. Storch EA, Caporino NE, Morgan JR, et al. Preliminary investigation of web-camera delivered cognitive-behavioral therapy for youth with obsessive-compulsive disorder. Psychiatry Res. 2011;189(3):407–12.

    Article  PubMed  Google Scholar 

  97. Storch EA, Murphy TK, Goodman WK, et al. A preliminary study of D-cycloserine augmentation of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder. Biol Psychiatry. 2010;68(11):1073–6.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  98. Strunk DR, DeRubeis RJ, Chiu AW, Alvarez J. Patients’ competence in and performance of cognitive therapy skills: relation to the reduction of relapse risk following treatment for depression. J Consult Clin Psychol. 2007;75(4):523–30.

    Article  PubMed  Google Scholar 

  99. van Minnen A, Hendriks L, Olff M. When do trauma experts choose exposure therapy for PTSD patients? A controlled study of therapist and patient factors. Beh Res Ther. 2010;48(4):312–20.

    Article  Google Scholar 

  100. Farrell NR, Deacon BJ, Kemp JJ, Dixon LJ, Sy JT. Do negative beliefs about exposure therapy cause its suboptimal delivery? An experimental investigation. J Anxiety Dis. 2013;27(8):763–71.

    Article  Google Scholar 

  101. Eley TC, Hudson JL, Creswell C, et al. Therapygenetics: the 5HTTLPR and response to psychological therapy. Mol Psychiatry. 2012;17(3):236–7.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  102. McGrath CL, Kelley ME, Holtzheimer PE, et al. Toward a neuroimaging treatment selection biomarker for major depressive disorder. JAMA Psychiatry. 2013;70(8):821–9.

    Article  PubMed Central  PubMed  Google Scholar 

  103. Wolitzky-Taylor KB, Arch JJ, Rosenfield D, Craske MG. Moderators and non-specific predictors of treatment outcome for anxiety disorders: a comparison of cognitive behavioral therapy to acceptance and commitment therapy. J Consult Clin Psychol. 2012;80(5):786–99.

    Article  PubMed  Google Scholar 

  104. DeRubeis RJ, Cohen ZD, Forand NR, Fournier JC, Gelfand LA, Lorenzo-Luaces L. The Personalized Advantage Index: translating research on prediction into individualized treatment recommendations. A demonstration PLoS One. 2014;9(1):e83875.

    Article  PubMed  CAS  Google Scholar 

  105. Lindhiem O, Kolko DJ, Cheng Y. Predicting psychotherapy benefit: a probabilistic and individualized approach. Behav Ther. 2012;43(2):381–92.

    Article  PubMed Central  PubMed  Google Scholar 

  106. Beidas RS, Lindhiem O, Brodman DM, et al. A probabilistic and individualized approach for predicting treatment gains: an extension and application to anxiety disordered youth. Behav Ther. 2014;45(1):126–36.

    Article  PubMed Central  PubMed  Google Scholar 

  107. Kapelner A, Krieger A. Matching on-the-fly: sequential allocation with higher power and efficiency. Biometrics. 2014;70(2):378–88.

    Article  PubMed  Google Scholar 

  108. Murphy SA, Collins LM, Rush AJ. Customizing treatment to the patient: adaptive treatment strategies. Drug Alcohol Depend. 2007;88 Suppl 2:S1–3.

    Article  PubMed Central  PubMed  Google Scholar 

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Conflict of Interest

Dr. Caporino declares that she has no conflict of interest.

Dr. Storch reports grants from NIH; grants from AHRQ; personal fees from Wiley, American Psychological Association, Elsevier, Lawrence Erlbaum, and Springer; personal fees from Prophase, Inc.; personal fees from Rogers Memorial Hospital; and non-financial support and other from IOCDF, outside the submitted work.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Psychology, Georgia State University, P.O. Box 5010, Atlanta, GA, 30302-5010, USA

    Nicole E. Caporino

  2. Department of Pediatrics, University of South Florida, Tampa, FL, USA

    Eric A. Storch

  3. Department of Health Policy and Management, University of South Florida, Tampa, FL, USA

    Eric A. Storch

  4. Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, FL, USA

    Eric A. Storch

  5. Rogers Behavioral Health–Tampa Bay, Tampa, FL, USA

    Eric A. Storch

  6. All Children’s Hospital–Johns Hopkins Medicine, St. Petersburg, FL, USA

    Eric A. Storch

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  1. Nicole E. Caporino
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  2. Eric A. Storch
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Correspondence to Nicole E. Caporino.

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This article is part of the Topical Collection on Child and Developmental Psychiatry

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Caporino, N.E., Storch, E.A. Personalizing the Treatment of Pediatric Obsessive-Compulsive Disorder: Evidence for Predictors and Moderators of Treatment Outcomes. Curr Behav Neurosci Rep 3, 73–85 (2016). https://doi.org/10.1007/s40473-016-0066-5

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  • DOI: https://doi.org/10.1007/s40473-016-0066-5

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