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Vascular Aging and Disease of the Large Vessels: Role of Inflammation

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Abstract

Structural and functional arterial properties commonly impair with aging process. These effects on vasculature could act at many levels from microcirculation to large vessels. Above normal aging process classic cardio-vascular risk factors (hypertension, diabetes mellitus, dyslipidemia, etc.) accelerate the physiological process leading to premature structural and functional alterations that has also been termed early vascular aging. Target organ damage evaluation could be clinically important since these alterations precede by many years’ cardiovascular events and so their assessment can predict the onset of more serious and costly events giving the opportunity to prevent CV events by earlier therapeutic intervention. This review will focus on large artery functional properties and particularly on the role of inflammation on the aortic stiffening process.

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Fig. 1

Modified from reference [36]

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Modified from reference [36]

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Authors and Affiliations

  1. School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy

    Alessandro Maloberti, Nicola Triglione, Lucia Occhi, Francesco Panzeri, Ilaria Bassi, Francesco Pansera, Enrico Piccinelli, Alessio Peretti, Laura Garatti, Matteo Palazzini, Jinwei Sun, Enzo Grasso & Cristina Giannattasio

  2. Cardiology 4, “A. De Gasperis” Department, Niguarda Ca Granda Hospital, Piazza Ospedale Maggiore 3, 20159, Milan, Italy

    Alessandro Maloberti, Paola Vallerio, Nicola Triglione, Lucia Occhi, Francesco Panzeri, Ilaria Bassi, Francesco Pansera, Enrico Piccinelli, Alessio Peretti, Laura Garatti, Matteo Palazzini, Jinwei Sun, Enzo Grasso & Cristina Giannattasio

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  1. Alessandro Maloberti
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  2. Paola Vallerio
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  3. Nicola Triglione
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  4. Lucia Occhi
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  7. Francesco Pansera
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  9. Alessio Peretti
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  10. Laura Garatti
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  12. Jinwei Sun
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  13. Enzo Grasso
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  14. Cristina Giannattasio
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Corresponding author

Correspondence to Cristina Giannattasio.

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Funding

This research was supported by the Italian Ministry of University and Research (MIUR)—Department of Excellence project PREMIA (PREcision MedIcine Approach: bringing biomarker research to clinic). No further specific grant from funding agencies in the public, commercial, or not-for-profit sectors was received.

Conflict of interest

All the authors declares that they have no conflict of interest.

Additional information

This article is part of the topical collection on Vascular Aging and Arterial Stiffness.

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Maloberti, A., Vallerio, P., Triglione, N. et al. Vascular Aging and Disease of the Large Vessels: Role of Inflammation. High Blood Press Cardiovasc Prev 26, 175–182 (2019). https://doi.org/10.1007/s40292-019-00318-4

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  • DOI: https://doi.org/10.1007/s40292-019-00318-4

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