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A Review of the Development and Application of Generic Multi-Attribute Utility Instruments for Paediatric Populations

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Abstract

Multi-attribute utility instruments (MAUIs) are increasingly being used as a means of quantifying utility for the calculation of quality-adjusted life-years within the context of cost utility analysis. Traditionally, MAUIs have been developed and applied in adult populations. However, increasingly, researchers in health economics and other disciplines are recognising the importance of the measurement and valuation of health in both children and adolescents. Presently, there are nine generic MAUIs available internationally that have been used in paediatric populations: the Quality of Well-Being Scale (QWB), the Health Utility Index Mark 2 (HUI2), the HUI3, the Sixteen-dimensional measure of health-related quality of life (HRQoL) (16D), the Seventeen-dimensional measure of HRQoL (17D), the Assessment of Quality of Life 6-Dimension (AQoL-6D) Adolescent, the Child Health Utility 9D (CHU9D), the EQ-5D Youth version (EQ-5D-Y) and the Adolescent Health Utility Measure (AHUM). This paper critically reviews the development and application of the above nine MAUIs and discusses the specific challenges of health utility measurement in children and adolescents. Areas for further research relating to the development and application of generic MAUIs in paediatric populations are highlighted.

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Acknowledgments

We would like to thank Dr. Katherine Stevens, ScHARR, University of Sheffield, delegates from the 36th Australian Health Economics Society Conference, Adelaide 2014 and two anonymous reviewers for their helpful comments on a previous version of this manuscript. Financial support from an Australian National Health and Medical Research Council project grant 1021899 titled ‘Adolescent values for the economic evaluation of adolescent health care treatment and preventive programs’ is also gratefully acknowledged.

The authors declare that no conflicts of interest exist.

Author contributions

Gang Chen and Julie Ratcliffe drafted and critically revised the manuscript. Both authors approved the final submitted version. Julie Ratcliffe is the guarantor for the overall content of this paper.

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Appendix

Appendix

See Table 3.

Table 3 Multi-attribute utility instruments used in clinical and public health intervention studies

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Chen, G., Ratcliffe, J. A Review of the Development and Application of Generic Multi-Attribute Utility Instruments for Paediatric Populations. PharmacoEconomics 33, 1013–1028 (2015). https://doi.org/10.1007/s40273-015-0286-7

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