Introduction
Methods
Study population
Cardiac magnetic resonance imaging and analysis
Temporary stimulation procedure
Statistical methods
Results
Baseline characteristics |
n = 41 |
---|---|
Age (years) | 67 ± 10 |
Male | 24 (59 %) |
QRS (ms) | 153 ± 22 |
Stringent LBBB (n) | 28 |
Lenient LBBB (n) | 13 |
Ischaemic, n | 21 (51 %) |
NYHA class, n | |
I/II/III/I | 0/8/33/0 |
NT-pro BNP (ng/L)a
| 1509 ± 1318 |
RVEDV (ml) | 153 ± 53 |
RVESV (ml) | 90 ± 48 |
RVEF (%) | 43 ± 16 |
TAPSE (mm) | 18 ± 7 |
LVEDV (ml) | 277 ± 90 |
LVESV (ml) | 211 ± 81 |
LVEF (%) | 25 ± 8 |
LVSW (L·mmHg) | 5.5 ± 2.5 |
LVdP/dtmax (mmHg/s) | 868 ± 182 |
Scar (%)b
| 8.9 ± 11.5 |
Haemodynamic measurements
The effect of right ventricular stimulation on CRT
∆LVSW RVapex
Univariate | ∆LVSW RVapex
Multivariate | ∆LVSW LV Univariate | ∆LVSW LV Multivariate | ∆LVSW BiV Univariate | ∆LVSW BiV Multivariate | ∆LVSW BiV—LV Univariate | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
β | p | β | p | β | p | β | p | β | p | β | p | β | P | |
Ischemic (n/y) | 7.48 | 0.45 | − 13.53 | 0.31 | 5.61 | 0.71 | 15.80 | 0.07 | ||||||
Stringent LBBB (n/y) | 10.44 | 0.34 | 21.51 | 0.13 | 10.39 | 0.51 | − 5.72 | 0.55 | ||||||
PQ-time (ms) | − 0.05 | 0.76 | 0.03 | 0.88 | − 0.08 | 0.75 | − 0.12 | 0.43 | ||||||
Scar (%) | − 0.27 | 0.68 | − 1.23 | 0.27 | − 0.97 | 0.34 | 0.26 | 0.66 | ||||||
Septal scar (n/y) | − 3.67 | 0.78 | − 11.49 | 0.29 | − 2.54 | 0.89 | − 11.49 | 0.29 | ||||||
PL scar (n/y) | − 0.93 | 0.93 | 8.87 | 0.54 | − 2.27 | 0.89 | − 8.64 | 0.37 | ||||||
RVEDV (ml) | − 0.09 | 0.34 | − 0.28 | 0.02 | − 0.24 | 0.09 | 0.07 | 0.44 | ||||||
RVESV (ml) | − 0.19 | 0.07 | − 0.40 | < 0.01 | − 0.39 | 0.01 | 0.05 | 0.60 | ||||||
RVEF (%) | 0.64 | 0.04 | 0.68 | 0.02 | 1.03 | 0.01 | 1.01 | 0.02 | 1.23 | < 0.01 | 0.61 | 0.25 | 0.05 | 0.86 |
LVEDV (ml) | − 0.01 | 0.86 | − 0.16 | 0.04 | − 0.15 | 0.07 | 0.02 | 0.62 | ||||||
LVESV (ml) | − 0.04 | 0.53 | − 0.39 | 0.02 | − 0.20 | 0.08 | 0.02 | 0.76 | ||||||
LVEF (%) | 1.14 | 0.06 | 0.38 | 0.63 | 1.88 | 0.03 | 0.89 | 0.44 | 2.76 | < 0.01 | 2.76 | < 0.01 | 0.58 | 0.26 |
LVSW (L·mmHg) | − 1.08 | 0.60 | − 2.66 | 0.34 | − 2.36 | 0.45 | − 1.03 | 0.59 | ||||||
LVdP/dtmax (mmHg/s) | 0.02 | 0.52 | 0.03 | 0.35 | 0.05 | 0.22 | < 0.01 | 0.88 |
The effect of scar location on CRT
Scar (%) | Anterior wall | Septal wall | Inferior wall | Lateral wall |
---|---|---|---|---|
LV better
| 19.9 ± 22.3 % | 8.9 ± 7.8 % | 6.7 ± 5.8 % | 9.8 ± 8.7 % |
BiV better
| 39.9 ± 29.7 % | 26.0 ± 18.6 % | 12.1 ± 13.0 % | 8.4 ± 6.4 % |
p
-value
| 0.20 | 0.16 | 0.48 | 0.72 |