Skip to main content

Advertisement

Log in

Study of the Effect of Bisphenol A on Oxidative Stress in Children with Autism Spectrum Disorders

  • Original Article
  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

The role of bisphenol A (BPA) in autism was investigated in 49 children (mean age = 5.950 ± 1.911 years) with autism spectrum disorders (ASDs) and 40 comparable age and sex matched children used as controls (mean age = 5.333 ± 2.279 years). In addition, 8-Hydroxydeoxyguanosine (8-oxodG) was also studied as a biomarker of oxidative stress in the same set of two selected groups. The results showed that both BPA and 8-oxodG were significantly higher in children with autism than those of control children (p values = 0.025 and 0.0001, respectively). There were positive correlations between both BPA and 8-oxodG with ASDs severity (r = 0.400 and 0.805, respectively), these correlations were highly significant (p values = 0.004 and 0.001, respectively). There was a significance positive correlation between BMI and BPA, but the correlation between BMI and 8-oxodG was not significant in children with autism. The observed results revealed that BPA may increase oxidative stress resulting in mitochondrial dysfunction that affecting the behavior and functioning of ASDs children.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Makris KC, Andra SS, Jia A, Herrick L, Christophi CA, Snyder SA, et al. Association between water consumption from polycarbonate containers and bisphenol A intake during harsh environmental conditions in summer. Environ Sci Technol. 2013;47:3333–43.

    Article  CAS  PubMed  Google Scholar 

  2. Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV. Human exposure to bisphenol A (BPA). Reprod Toxicol. 2007;24(2):139–77.

    Article  CAS  PubMed  Google Scholar 

  3. Rochester JR. Bisphenol A and human health: a review of the literature. Reprod Toxicol. 2013;42:132–55.

    Article  CAS  PubMed  Google Scholar 

  4. Kardas F, Bayram AK, Demirci E, Akin L, Ozmen S, Kendirci M, et al. Increased serum phthalates (MEHP, DEHP) and bisphenol a concentrations in children with autism spectrum disorder: the role of endocrine disruptors in autism etiopathogenesis. J Child Neurol. 2016;31(5):629–35.

    Article  PubMed  Google Scholar 

  5. Stein TP, Schluter MD, Steer RA, Guo L, Ming X. Bisphenol A exposure in children with autism spectrum disorders. Autism Res. 2015;8:272–83.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Miodovnik A, Engel SM, Canfield RL, Zhu C, Silva MJ, Calafat AM, et al. Enodcrine disruptors and childhood social impairment. Neurotoxicology. 2011;32:261–7.

    Article  CAS  PubMed  Google Scholar 

  7. Larsson M, Weiss B, Janson S, Sundell J, Bornehag CG. Associations between indoor environmental factors and parental-reported autistic spectrum disorders in children 6–8 years of age. Neurotoxicology. 2009;30:822–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Szychowski KA, W´ojtowicz AK. Components of plastic disrupt the function of the nervous system. Poste¸py Higieny iMedycyny Do´swiadczalnej. 2013; 67:499–506.

  9. Xu X, Xie L, Hong X, et al. Perinatal exposure to bisphenol-A inhibits synaptogenesis and affects the synaptic morphological development in offspring male mice. Chemosphere. 2013;91(8):1073–81.

    Article  CAS  PubMed  Google Scholar 

  10. American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington DC; 1994.

  11. Herbert MR. Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders. Curr Opin Neurol. 2010;23(2):103–10.

    Article  PubMed  Google Scholar 

  12. Hallmayer J, Cleveland S, Torres A, Phillips J, Cohen B, Torigoe T, et al. Genetic heritability and shared environmental factors among twin pairs with autism. Arch Gen Psychiatry. 2011;68(11):1095–102.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Faber S, Zinn GM, Boggess A, Fahrenholz T, Kern JC, Kingston HS. A cleanroom sleeping environment’s impact on markers of oxidative stress, immune dysregulation, and behavior in children with autism spectrum disorders BMC. Comple Alter Med. 2015;15(1):71.

    Article  Google Scholar 

  14. Rossignol DA, Frye RE. A review of research trends in physiological abnormalitiesin autism spectrum disorders: immune dysregulation, inflammation, oxidativestress, mitochondrial dysfunction and environmental toxicant exposures. Mol Psychiatry. 2012;17:389–401.

    Article  CAS  PubMed  Google Scholar 

  15. Kourouma A, Peng D, Chao Q, Changjiang L, Chengmin W, Wenjuan F, et al. Bisphenol A induced reactive oxygen species (ROS) in the liver and affect epididymal semen quality in adults Sprague-Dawley rats. J Toxi Enviro Health Sci. 2014;6(4):103–12.

    Article  Google Scholar 

  16. Moon MK, Kim MJ, Jung IK, Koo YD, Ann HY, Lee KJ, Kim SH, Yoon YC, Cho BJ, Park KS, Jang HC, Park YJ. Bisphenol A impairs mitochondrial function in the liver at doses below the no observed adverse effect level. J Korean Med Sci. 2012;27:644–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Eid JI, Eissa SM, El-Ghor AA. Bisphenol A induces oxidative stress and DNA damage in hepatic tissue of female rat offspring. J Basic Appl Zoology. 2015;71:10–9.

    Article  CAS  Google Scholar 

  18. Karihtala P, Soini Y. Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies. Apmis. 2007;115(2):81–103.

    Article  CAS  PubMed  Google Scholar 

  19. Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2′ -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health. 2009;27:120–39.

    Article  CAS  Google Scholar 

  20. DSM-IV-TR. A. Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Association; 2000.

    Google Scholar 

  21. Schopler E, Reichler RJ, DeVellis RF, Daly K. Toward objective classification of childhood autism: childhood autism rating scale (CARS). J Autism Dev Disord. 1980;10(1):91–103.

    Article  CAS  PubMed  Google Scholar 

  22. Tanner JM, Hiernaux J, Jarman S. Growth and physique studies. In: Weiner JS, Lourie JA, editors. Human biology: a guide to field methods, I.B.P. handbook No.9. Oxford and Edinburgh: Blackwell Scientific Publications; 1969. p. 1–29.

  23. WHO| The WHO Child Growth Standards, 2007-2017. WHO.http://www.who.int/childgrowth/en/.

  24. Kaur K, Chauhan V, Gu F, Chauhan A. Bisphenol A induces oxidative stress and mitochondrial dysfunction in lymphoblasts from children with autism and unaffected siblings. Free Radic Biol Med. 2014;76:25–33.

    Article  CAS  PubMed  Google Scholar 

  25. Rossignol DA, Frye RE. Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Front Physiol. 2014; 5(150):1–15.http://journal.frontiersin.org/article/10.3389/fphys.2014.00150/full Doi: 10.3389/fphys.2014.00150

  26. Meguid NA, Dardir AA, Abdel-Raouf ER, Hashish A. Evaluation of oxidative stress in autism: defective antioxidant enzymes and increased lipid peroxidation. Biol Trace Elem Res. 2011;143:58–65.

    Article  CAS  PubMed  Google Scholar 

  27. Vafeiadi M, Roumeliotaki T, Myridakis A, Chalkiadaki G, Eleni Fthenou E, et al. Association of early life exposure to bisphenol A with obesity and cardiometabolic traits in childhood. Environ Res. 2016;146:379–87.

    Article  CAS  PubMed  Google Scholar 

  28. Rossignol DA, Frye RE. Mitochondrial dysfunction in autism spectrum disorders: asystematic review and meta-analysis. Mol Psychiatry. 2012;. doi:10.1038/mp.2010.136.

    PubMed Central  Google Scholar 

  29. Napoli E, Wong S, Giulivi C. Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism. Mol Autism. 2013;4:2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Braun JM, Kalkbrenner AE, Calafat AM, Yolton K, Ye X, Dietrich KN, et al. Impact of early-life bisphenol A exposure on behavior and executive function in children. Pediatrics. 2011;128(5):873–82.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We would like to thank all children participated in this study and their families.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hala M. Zeidan.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Metwally, F.M., Rashad, H., Zeidan, H.M. et al. Study of the Effect of Bisphenol A on Oxidative Stress in Children with Autism Spectrum Disorders. Ind J Clin Biochem 33, 196–201 (2018). https://doi.org/10.1007/s12291-017-0667-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12291-017-0667-0

Keywords

Navigation