Skip to main content

Advertisement

Log in

Anxiety, depression, and quality of life in German ambulatory breast cancer patients

  • Original Article
  • Published:
Breast Cancer Aims and scope Submit manuscript

Abstract

Background

The aim of the study was to determine the predictors of health-related quality of life in ambulatory breast cancer patients.

Methods

A total of 107 breast cancer outpatients were tested with the Hospital Anxiety and Depression Scale (HADS) and the quality of life instrument EORTC QLQ-C30. Furthermore, the degree of social support and shared decision making (SDM) were assessed.

Results

In nearly all domains of EORTC QLQ-C30 the patients reported worse mean scores than the general population in a clinically significant range, especially in the symptom scales. Therapy-related factors and the degree of SDM contributed only marginally to quality of life. Social support, however, proved to be predictive of better mental health and better quality of life in many domains.

Conclusion

Irrespective of the therapy, the social network of the patients should be activated to help the patients to cope with the disease. However, the findings do not support the idea that enhanced SDM would have beneficial effects on mental health.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Singer S, Das-Munshi J, Brähler E. Prevalence of mental health conditions in cancer patients in acute care—a meta-analysis. Ann Oncol. 2010;21:925–30.

    Article  CAS  PubMed  Google Scholar 

  2. Kramer JA, Curran D, Piccart M, De Haes JCJM, Bruning P, Klijn J, et al. Identification and interpretation of clinical and quality of life prognostic factors for survival and response to treatment in first-line chemotherapy in advanced breast cancer. Eur J Cancer. 2000;36:1498–506.

    Article  CAS  PubMed  Google Scholar 

  3. Engel J, Kerr J, Schlesinger-Raab A, Eckel R, Sauer H, Holzel D. Predictors of quality of life of breast cancer patients. Acta Oncol. 2003;42:710–8.

    Article  PubMed  Google Scholar 

  4. Waldmann A, Pritzkuleit R, Raspe H, Katalinic A. The OVIS study: health related quality of life measured by the EORTC QLQ-C30 and -BR23 in German female patients with breast cancer from Schleswig-Holstein. Qual Life Res. 2007;16:767–76.

    Article  CAS  PubMed  Google Scholar 

  5. Arndt V, Merx H, Sturmer T, Stegmaier C, Ziegler H, Brenner H. Age-specific detriments to quality of life among breast cancer patients one year after diagnosis. Eur J Cancer. 2004;40:673–80.

    Article  CAS  PubMed  Google Scholar 

  6. Schou I, Ekeberg O, Sandvik L, Hjermstad MJ, Ruland CM. Multiple predictors of health-related quality of life in early stage breast cancer. Data from a year follow-up study compared with the general population. Qual Life Res. 2005;14:1813–23.

    Article  PubMed  Google Scholar 

  7. Groenvold M, Fayers PM, Sprangers MAG, Bjorner JB, Klee MC, Aaronson NK, et al. Anxiety and depression in breast cancer patients at low risk of recurrence compared with the general population: a valid comparison? J Clin Epidemiol. 1999;52:523–30.

    Article  CAS  PubMed  Google Scholar 

  8. Schwarz R, Krauss O, Hoeckel M, Meyer A, Zenger M, Hinz A. The course of anxiety and depression in patients with breast cancer and gynaecological cancer. Breast Care. 2008;3:417–22.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Montazeri A. Health-related quality of life in breast cancer patients: a bibliographic review of the literature from 1974 to 2007. J Exp Clin Cancer Res 2008;27:32.

    Google Scholar 

  10. Kornblith AB, Herndon JE, Zuckerman E, Viscoli CM, Horwitz RI, Cooper MR, et al. Social support as a buffer to the psychological impact of stressful life events in women with breast cancer. Cancer. 2001;91:443–54.

    Article  CAS  PubMed  Google Scholar 

  11. Manning-Walsh J. Social support as a mediator between symptom distress and quality of life in women with breast cancer. JOGNN J Obst Gyn Neo. 2005;34:482–93.

    Article  Google Scholar 

  12. Kraetschmer N, Sharpe N, Urowitz S, Deber RB. How does trust affect patient preferences for participation in decision-making? Health Expect. 2004;7:317–26.

    Article  PubMed  Google Scholar 

  13. O’Brien MA, Whelan TJ, Charles C, Ellis PM, Gafni A, Lovrics P, et al. Women’s perceptions of their treatment decision-making about breast cancer treatment. Patient Educ Couns. 2008;73:431–6.

    Article  PubMed  Google Scholar 

  14. Hinz A, Schwarz R. Anxiety and depression in the general population. A standardization study of the Hospital Anxiety and Depression Scale (in German with English abstract). Psychother Psychosom Med Psychol. 2001;51:193–200.

    Article  CAS  PubMed  Google Scholar 

  15. Schwarz R, Hinz A. Reference data for the quality of life questionnaire EORTC QLQ-C30 in the general German population. Eur J Cancer. 2001;37:1345–51.

    Article  CAS  PubMed  Google Scholar 

  16. Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand. 1983;67:361–70.

    Article  CAS  PubMed  Google Scholar 

  17. Singer S, Kuhnt S, Götze H, Hauss J, Hinz A, Liebmann A, et al. Hospital Anxiety and Depression Scale cut-off scores for cancer patients in acute care. Br J Cancer. 2009;100:908–12.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Hinz A, Krauss O, Hauss JP, Hockel M, Kortmann RD, Stolzenburg JU, et al. Anxiety and depression in cancer patients compared with the general population. Eur J Cancer Care. 2010;19:522–9.

    Article  CAS  Google Scholar 

  19. Brennan C, Worrall-Davies A, McMillan D, Gilbody S, House A. The Hospital Anxiety and Depression Scale: a diagnostic meta-analysis of case-finding ability. J Psychosom Res. 2010;69:371–8.

    Article  PubMed  Google Scholar 

  20. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85:365–76.

    Article  CAS  PubMed  Google Scholar 

  21. Groenvold M, Klee MC, Sprangers MAG, Aaronson NK. Validation of the EORTC QLQ-C30 quality of life questionnaire through combined qualitative and quantitative assessment of patient-observer agreement. J Clin Epidemiol. 1997;50:441–50.

    Article  CAS  PubMed  Google Scholar 

  22. Osoba D. What has been learned from measuring health-related quality of life in clinical oncology. Eur J Cancer. 1999;35:1565–70.

    Article  CAS  PubMed  Google Scholar 

  23. Ogce F, Ozkan S, Baltalarli B. Psychosocial stressors, social support and socio-demographic variables as determinants of quality of life of Turkish breast cancer patients. Asian Pac J Cancer Prev. 2007;8:77–82.

    PubMed  Google Scholar 

  24. Chou AF, Stewart SL, Wild RC, Bloom JR. Social support and survival in young women with breast carcinoma. Psychooncology. 2012;21:125–33.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Vaglio J Jr, Conard M, Poston WS, O’Keefe J, Haddock CK, House J, et al. Testing the performance of the ENRICHD Social Support Instrument in cardiac patients. Health Qual Life Outcomes. 2004;2:24.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andreas Hinz.

About this article

Cite this article

Schleife, H., Sachtleben, C., Finck Barboza, C. et al. Anxiety, depression, and quality of life in German ambulatory breast cancer patients. Breast Cancer 21, 208–213 (2014). https://doi.org/10.1007/s12282-012-0378-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12282-012-0378-6

Keywords

Navigation