Abstract
Although major depressive disorder (MDD) is one of the main causes of global disease burden, there is little evidence about the association between personality traits and depressive symptoms in Latin America. The aim of this study was to examine the possibility that perceived stress might be a mediator of the association between neuroticism and depressive and anxious symptoms. Two hundred seventy four Colombian subjects (mean age 21.3 years) were evaluated with the short version of the Big Five Inventory (BFI-S), the Center for Epidemiologic Studies Depression Scale (CES-D), the Hospital Anxiety and Depression Scale (HADS), the Zung Self-Rating Anxiety Scale (ZSAS) and the Perceived Stress Scale-10. Both neuroticism and perceived stress were significantly correlated with higher scores in depressive and anxious symptoms (p < 0.01). Perceived stress was a significant mediator of the relationship between neurotic trait and depressive and anxious symptoms. Our results are one of the first descriptions of the role of perceived stress as a mediator of the association between neuroticism and psychological distress. These findings are of particular importance, in the context of the need for more evidence about the psychosocial risk factors for MDD in Latin America.
Similar content being viewed by others
References
Aalto-Setala, T., Marttunen, M., Tuulio-Henriksson, A., Poikolainen, K., & Lonnqvist, J. (2001). One-month prevalence of depression and other DSM-IV disorders among young adults. Psychological Medicine, 31(5), 791–801.
Abbasi, I. S. (2016). The role of neuroticism in the maintenance of chronic baseline stress perception and negative affect. The Spanish Journal of Psychology, 19, E9. doi:10.1017/sjp.2016.7.
Adan, A., Navarro, J. F., & Forero, D. A. (2016). Personality profile of binge drinking in university students is modulated by sex. A study using the alternative five factor model. Drug and Alcohol Dependence, 165, 120–125. doi:10.1016/j.drugalcdep.2016.05.015.
Arrivillaga Quintero, M., Cortés García, C., Goicochea Jiménez, V. L., & Lozano Ortíz, T. M. (2004). Caracterización de la depresión en jóvenes universitarios. Universitas Psychologica, 3(1), 17–25.
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®). Arlington: American Psychiatric Association.
Barnhofer, T., & Chittka, T. (2010). Cognitive reactivity mediates the relationship between neuroticism and depression. Behaviour Research and Therapy, 48(4), 275–281. doi:10.1016/j.brat.2009.12.005.
Bergdahl, J., & Bergdahl, M. (2002). Perceived stress in adults: prevalence and association of depression, anxiety and medication in a Swedish population. Stress and Health, 18(5), 235–241.
Bovier, P. A., Chamot, E., & Perneger, T. V. (2004). Perceived stress, internal resources, and social support as determinants of mental health among young adults. Quality of Life Research, 13(1), 161–170.
Bromet, E., Andrade, L. H., Hwang, I., Sampson, N. A., Alonso, J., de Girolamo, G., et al. (2011). Cross-national epidemiology of DSM-IV major depressive episode. BMC Medicine, 9, 90. doi:10.1186/1741-7015-9-90.
Campo-Arias, A., Díaz-Martínez, L. A., Rueda-Jaimes, G. E., Cadena-Afanador, L. d. P., & Hernández, N. L. (2007). Psychometric properties of the CES-D scale among Colombian adults from the general population. Revista Colombiana de Psiquiatría, 36(4), 664–674.
Campo-Arias, A., Oviedo, H. C., & Herazo, E. (2014). Escala de Estrés Percibido-10: Desempeño psicométrico en estudiantes de medicina de Bucaramanga, Colombia. Revista de la Facultad de Medicina, 62(3), 1–24.
Chamorro-Premuzic, T., Gomà-i-Freixanet, M., Furnham, A., & Muro, A. (2009). Personality, self-estimated intelligence, and uses of music: a Spanish replication and extension using structural equation modeling. Psychology of Aesthetics, Creativity, and the Arts, 3(3), 149.
Cohen, J. (1992). A power primer. Psychological Bulletin, 112(1), 155–159.
Cohen, S., Kamarck, T., & Mermelstein, R. (1983). A global measure of perceived stress. Journal of Health and Social Behavior, 24(4), 385–396.
Conard, M. A., & Matthews, R. A. (2008). Modeling the stress process: personality eclipses dysfunctional cognitions and workload in predicting stress. Personality and Individual Differences, 44(1), 171–181.
Costa Jr., P. T., & McCrae, R. R. (1980). Influence of extraversion and neuroticism on subjective well-being: happy and unhappy people. Journal of Personality and Social Psychology, 38(4), 668–678.
De La Ossa, S., Martinez, Y., Herazo, E., & Campo, A. (2009). Study of internal consistency and factor structure of three versions of the Zung's rating instrument for anxiety disorders. Colombia Médica, 40(1), 71–77.
Demyttenaere, K., Bruffaerts, R., Posada-Villa, J., Gasquet, I., Kovess, V., Lepine, J. P., et al. (2004). Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization world mental health surveys. JAMA, 291(21), 2581–2590. doi:10.1001/jama.291.21.2581.
Diehr, P. H., Derleth, A. M., McKenna, S. P., Martin, M. L., Bushnell, D. M., Simon, G., et al. (2006). Synchrony of change in depressive symptoms, health status, and quality of life in persons with clinical depression. Health and Quality of Life Outcomes, 4, 27. doi:10.1186/1477-7525-4-27.
Ebstrup, J. F., Eplov, L. F., Pisinger, C., & Jorgensen, T. (2011). Association between the five factor personality traits and perceived stress: is the effect mediated by general self-efficacy? Anxiety, Stress, and Coping, 24(4), 407–419. doi:10.1080/10615806.2010.540012.
Ferrari, A. J., Charlson, F. J., Norman, R. E., Patten, S. B., Freedman, G., Murray, C. J., et al. (2013). Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoS Medicine, 10(11), e1001547. doi:10.1371/journal.pmed.1001547.
Galvez, J. M., Forero, D. A., Fonseca, D. J., Mateus, H. E., Talero-Gutierrez, C., & Velez-van-Meerbeke, A. (2014). Evidence of association between SNAP25 gene and attention deficit hyperactivity disorder in a Latin American sample. Attention Deficit and Hyperactivity Disorders, 6(1), 19–23. doi:10.1007/s12402-013-0123-9.
Garcia-Alvarez, R. (1986). Epidemiology of depression in Latin America. Psychopathology, 19(Suppl. 2), 22–25.
Gonzalez-Giraldo, Y., Camargo, A., Lopez-Leon, S., & Forero, D. A. (2015). No association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 genes and depressive symptoms in a sample of healthy Colombian subjects. Depression Research and Treatment, 2015, 145483. doi:10.1155/2015/145483.
Goodwin, R. D., & Gotlib, I. H. (2004). Gender differences in depression: the role of personality factors. Psychiatry Research, 126(2), 135–142. doi:10.1016/j.psychres.2003.12.024.
Griffith, J. W., Zinbarg, R. E., Craske, M. G., Mineka, S., Rose, R. D., Waters, A. M., et al. (2010). Neuroticism as a common dimension in the internalizing disorders. Psychological Medicine, 40(7), 1125–1136. doi:10.1017/S0033291709991449.
Hakulinen, C., Elovainio, M., Pulkki-Raback, L., Virtanen, M., Kivimaki, M., & Jokela, M. (2015). Personality and depressive symptoms: individual participant meta-analysis of 10 cohort studies. Depression and Anxiety, 32(7), 461–470. doi:10.1002/da.22376.
Hamad, R., Fernald, L. C., Karlan, D. S., & Zinman, J. (2008). Social and economic correlates of depressive symptoms and perceived stress in south African adults. Journal of Epidemiology and Community Health, 62(6), 538–544. doi:10.1136/jech.2007.066191.
Harenski, C. L., Kim, S. H., & Hamann, S. (2009). Neuroticism and psychopathy predict brain activation during moral and nonmoral emotion regulation. Cognitive, Affective, & Behavioral Neuroscience, 9(1), 1–15. doi:10.3758/cabn.9.1.1.
Hayes, A. F. (2013). Introduction to mediation, moderation, and conditional process analysis: A regression-based approach. New York: Guilford Press.
Henrich, J., Heine, S. J., & Norenzayan, A. (2010). The weirdest people in the world? The Behavioral and Brain Sciences, 33(2–3), 61–83 discussion 83-135. doi:10.1017/S0140525X0999152X.
Hernandez, H. G., Mahecha, M. F., Mejia, A., Arboleda, H., & Forero, D. A. (2014). Global long interspersed nuclear element 1 DNA methylation in a Colombian sample of patients with late-onset Alzheimer's disease. American Journal of Alzheimer's Disease and Other Dementias, 29(1), 50–53. doi:10.1177/1533317513505132.
Hernández-Pozo, M., Macías, D., Calleja, N., Cerezo, S., & del Valle Chauvet, C. (2008). Propiedades psicométricas del Inventario Zung del Estado de Ansiedad con mexicanos. Psychologia. Avances de la disciplina, 2(2), 19–46.
Herrero, M. J., Blanch, J., Peri, J. M., De Pablo, J., Pintor, L., & Bulbena, A. (2003). A validation study of the hospital anxiety and depression scale (HADS) in a Spanish population. General Hospital Psychiatry, 25(4), 277–283.
Hewitt, P. L., Flett, G. L., & Mosher, S. W. (1992). The perceived stress scale: factor structure and relation to depression symptoms in a psychiatric sample. Journal of Psychopathology and Behavioral Assessment, 14(3), 247–257.
Hinz, A., Finck, C., Gomez, Y., Daig, I., Glaesmer, H., & Singer, S. (2014). Anxiety and depression in the general population in Colombia: reference values of the hospital Anxiety and depression scale (HADS). Social Psychiatry and Psychiatric Epidemiology, 49(1), 41–49. doi:10.1007/s00127-013-0714-y.
Ibrahim, A. K., Kelly, S. J., Adams, C. E., & Glazebrook, C. (2013). A systematic review of studies of depression prevalence in university students. Journal of Psychiatric Research, 47(3), 391–400. doi:10.1016/j.jpsychires.2012.11.015.
Kendler, K. S., Kessler, R. C., Walters, E. E., MacLean, C., Neale, M. C., Heath, A. C., et al. (1995). Stressful life events, genetic liability, and onset of an episode of major depression in women. The American Journal of Psychiatry, 152(6), 833–842. doi:10.1176/ajp.152.6.833.
Kendler, K. S., Kuhn, J., & Prescott, C. A. (2004). The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression. The American Journal of Psychiatry, 161(4), 631–636. doi:10.1176/appi.ajp.161.4.631.
Kessler, R. C., Matthias, A., Anthony, J. C., De Graaf, R., Demyttenaere, K., Gasquet, I., et al. (2007). Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization’s world mental health survey initiative. World Psychiatry, 6(3), 168–176.
Kim, H. Y. (2013). Statistical notes for clinical researchers: assessing normal distribution (2) using skewness and kurtosis. Restorative Dentistry & Endodontics, 38(1), 52–54. doi:10.5395/rde.2013.38.1.52.
Kim, H. J., & Abraham, I. (2016). Psychometric comparison of single-item, short, and comprehensive depression screening measures in Korean young adults. International Journal of Nursing Studies, 56, 71–80. doi:10.1016/j.ijnurstu.2015.12.003.
Kim, S. E., Kim, H. N., Cho, J., Kwon, M. J., Chang, Y., Ryu, S., et al. (2016). Direct and indirect effects of five factor personality and gender on depressive symptoms mediated by perceived stress. PloS One, 11(4), e0154140. doi:10.1371/journal.pone.0154140.
Kotov, R., Gamez, W., Schmidt, F., & Watson, D. (2010). Linking “big” personality traits to anxiety, depressive, and substance use disorders: a meta-analysis. Psychological Bulletin, 136(5), 768–821. doi:10.1037/a0020327.
Kupfer, D. J., Frank, E., & Phillips, M. L. (2012). Major depressive disorder: new clinical, neurobiological, and treatment perspectives. Lancet, 379(9820), 1045–1055. doi:10.1016/S0140-6736(11)60602-8.
Lahey, B. B. (2009). Public health significance of neuroticism. The American Psychologist, 64(4), 241–256. doi:10.1037/a0015309.
Lang, F. R., John, D., Ludtke, O., Schupp, J., & Wagner, G. G. (2011). Short assessment of the big five: robust across survey methods except telephone interviewing. Behavior Research Methods, 43(2), 548–567. doi:10.3758/s13428-011-0066-z.
Leach, L. S., Christensen, H., Mackinnon, A. J., Windsor, T. D., & Butterworth, P. (2008). Gender differences in depression and anxiety across the adult lifespan: the role of psychosocial mediators. Social Psychiatry and Psychiatric Epidemiology, 43(12), 983–998. doi:10.1007/s00127-008-0388-z.
Lee, E. H. (2012). Review of the psychometric evidence of the perceived stress scale. Asian Nursing Research, 6(4), 121–127. doi:10.1016/j.anr.2012.08.004.
Mohamadi Hasel, K., Besharat, M. A., Abdolhoseini, A., Alaei Nasab, S., & Niknam, S. (2013). Relationships of personality factors to perceived stress, depression, and oral lichen planus severity. International Journal of Behavioral Medicine, 20(2), 286–292. doi:10.1007/s12529-012-9226-5.
Morgan-Lopez, A. A., & MacKinnon, D. P. (2006). Demonstration and evaluation of a method for assessing mediated moderation. Behavior Research Methods, 38(1), 77–87.
Muñoz, R. A., McBride, M. E., Brnabic, A. J., López, C. J., Hetem, L. A. B., Secin, R., et al. (2005). Major depressive disorder in Latin America: the relationship between depression severity, painful somatic symptoms, and quality of life. Journal of Affective Disorders, 86(1), 93–98.
Newton-Howes, G., Tyrer, P., Johnson, T., Mulder, R., Kool, S., Dekker, J., et al. (2014). Influence of personality on the outcome of treatment in depression: systematic review and meta-analysis. Journal of Personality Disorders, 28(4), 577–593. doi:10.1521/pedi_2013_27_070.
O’Connor, D. B., & Shimizu, M. (2002). Sense of personal control, stress and coping style: a cross-cultural study. Stress and Health, 18(4), 173–183.
Ormel, J., Oldehinkel, A. J., & Brilman, E. I. (2001). The interplay and etiological continuity of neuroticism, difficulties, and life events in the etiology of major and subsyndromal, first and recurrent depressive episodes in later life. American Journal of Psychiatry, 158(6), 885–891.
Ormel, J., Bastiaansen, A., Riese, H., Bos, E. H., Servaas, M., Ellenbogen, M., et al. (2013). The biological and psychological basis of neuroticism: current status and future directions. Neuroscience and Biobehavioral Reviews, 37(1), 59–72. doi:10.1016/j.neubiorev.2012.09.004.
Parker, G., Cheah, Y.-C., & Roy, K. (2001). Do the Chinese somatize depression? A cross-cultural study. Social Psychiatry and Psychiatric Epidemiology, 36(6), 287–293.
Perea, C. S., Paternina, A. C., Gomez, Y., & Lattig, M. C. (2012). Negative affectivity moderated by BDNF and stress response. Journal of Affective Disorders, 136(3), 767–774. doi:10.1016/j.jad.2011.09.043.
Preacher, K. J., & Kelley, K. (2011). Effect size measures for mediation models: quantitative strategies for communicating indirect effects. Psychological Methods, 16(2), 93–115. doi:10.1037/a0022658.
Quilty, L. C., Van Ameringen, M., Mancini, C., Oakman, J., & Farvolden, P. (2003). Quality of life and the anxiety disorders. Journal of Anxiety Disorders, 17(4), 405–426.
Radloff, L. S. (1977). The CES-D scale a self-report depression scale for research in the general population. Applied Psychological Measurement, 1(3), 385–401.
Rammstedt, B., Goldberg, L. R., & Borg, I. (2010). The measurement equivalence of big five factor markers for persons with different levels of education. Journal of Research in Personality, 44(4), 53–61. doi:10.1016/j.jrp.2009.10.005.
Remor, E. (2006). Psychometric properties of a European Spanish version of the perceived stress scale (PSS). The Spanish Journal of Psychology, 9(1), 86–93.
Renau, V., Oberst, U., Gosling, S. D., Rusiñol, J., & Lusar, A. C. (2013). Translation and validation of the ten-item-personality inventory into Spanish and Catalan. Aloma: revista de psicologia, ciències de l’educació i de l’esport Blanquerna, 31(2), 85–97.
Richards, D. (2011). Prevalence and clinical course of depression: a review. Clinical Psychology Review, 31(7), 1117–1125.
Richards, D., & Sanabria, A. S. (2014). Point-prevalence of depression and associated risk factors. The Journal of Psychology, 148(3), 305–326. doi:10.1080/00223980.2013.800831.
Roohafza, H., Feizi, A., Afshar, H., Mazaheri, M., Behnamfar, O., Hassanzadeh-Keshteli, A., et al. (2016). Path analysis of relationship among personality, perceived stress, coping, social support, and psychological outcomes. World Journal of Psychiatry, 6(2), 248–256. doi:10.5498/wjp.v6.i2.248.
Suls, J., & Martin, R. (2005). The daily life of the garden-variety neurotic: reactivity, stressor exposure, mood spillover, and maladaptive coping. Journal of Personality, 73(6), 1485–1509. doi:10.1111/j.1467-6494.2005.00356.x.
Tellegen, A., Lykken, D. T., Bouchard, T. J., Wilcox, K. J., Segal, N. L., & Rich, S. (1988). Personality similarity in twins reared apart and together. Journal of Personality and Social Psychology, 54(6), 1031.
Vazquez, F. L., Blanco, V., & Lopez, M. (2007). An adaptation of the Center for Epidemiologic Studies Depression Scale for use in non-psychiatric Spanish populations. Psychiatry Research, 149(1–3), 247–252. doi:10.1016/j.psychres.2006.03.004.
Versluis, A., Verkuil, B., Spinhoven, P., van der Ploeg, M. M., & Brosschot, J. F. (2016). Changing mental health and positive psychological well-being using ecological momentary interventions: a systematic review and meta-analysis. Journal of Medical Internet Research, 18(6), e152. doi:10.2196/jmir.5642.
Vos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., et al. (2012). Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the global Burden of disease study 2010. Lancet, 380(9859), 2163–2196. doi:10.1016/S0140-6736(12)61729-2.
Wongpakaran, N., & Wongpakaran, T. (2010). The Thai version of the PSS-10: An investigation of its psychometric properties. BioPsychoSocial Medicine, 4, 6. doi:10.1186/1751-0759-4-6.
Zigmond, A. S., & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica, 67(6), 361–370.
Zung, W. W. (1971). A rating instrument for anxiety disorders. Psychosomatics, 12(6), 371–379. doi:10.1016/S0033-3182(71)71479-0.
Acknowledgements
This study was supported by a research grant from Colciencias (grant # 823-2015). AA is supported by a research grant from the Spanish Ministry of Economy and Competitiveness (PSI2015-65026, MINECO/FEDER/UE). The authors thank Rodrigo González-Reyes, MD, PhD, Andrés Camargo, RN, MSc, Karen Jiménez, BSc and Juliana Villada, whom helped with recruitment of subjects.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
The authors declare that they have no conflict of interest.
Ethical Approval
“All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.”
Informed Consent
“Informed consent was obtained from all individual participants included in the study.”
Electronic supplementary material
Table S1
(DOCX 14 kb)
Rights and permissions
About this article
Cite this article
Pereira-Morales, A.J., Adan, A. & Forero, D.A. Perceived Stress as a Mediator of the Relationship between Neuroticism and Depression and Anxiety Symptoms. Curr Psychol 38, 66–74 (2019). https://doi.org/10.1007/s12144-017-9587-7
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12144-017-9587-7