Abstract
Free fatty acids are known to play a key role in promoting loss of insulin sensitivity, thereby causing insulin resistance and type 2 diabetes. However, the underlying mechanism involved is still unclear. In searching for the cause of the mechanism, it has been found that palmitate inhibits insulin receptor (IR) gene expression, leading to a reduced amount of IR protein in insulin target cells. PDK1-independent phosphorylation of PKCε causes this reduction in insulin receptor gene expression. One of the pathways through which fatty acid can induce insulin resistance in insulin target cells is suggested by these studies. We provide an overview of this important area, emphasizing the current status.
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Abbreviations
- IDDM:
-
insulin-dependent diabetes mellitus
- NIDDM:
-
non-insulin dependent diabetes mellitus
- IR:
-
insulin receptor
- FFA:
-
free fatty acid
- IRS:
-
insulin receptor substrate
- PI3 kinase:
-
phosphatidylinositol 3 phosphate kinase
- PIP2 :
-
phosphatidylinositol 4,5 bisphosphate
- DAG:
-
diacylglycerol
- PDK1:
-
phosphoinositide-dependent kinase-1
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Bhattacharya, S., Dey, D. & Roy, S.S. Molecular mechanism of insulin resistance. J Biosci 32, 405–413 (2007). https://doi.org/10.1007/s12038-007-0038-8
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DOI: https://doi.org/10.1007/s12038-007-0038-8