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Meta-analysis of GABRB3 Gene Polymorphisms and Susceptibility to Autism Spectrum Disorder

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Abstract

Several lines of evidence have suggested that the GABA receptor subunit β3 (GABRB3) gene is a genetic contributor in the autism spectrum disorder (ASD). The aberrant expression of GABRB3 is reported in ASD patients which may be a consequence of the presence of certain genetic variants in the promoter region of the gene. The associations between single-nucleotide polymorphisms (SNPs) within this gene and ASD have been analyzed in previous studies. However, the results are conflicting. In the present study, we performed a meta-analysis on association between two SNPs located in the promoter region of GABRB3 gene (rs4906902 and rs20317) and ASD. The literature search was performed based on criteria provided by the meta-analysis of observational studies in epidemiology (MOOSE). The association between mentioned SNPs and ASD was calculated using pooled odd ratios (ORs) and 95% confidence intervals. The result of the present meta-analysis indicates that neither rs4906902 nor rs20317 are significantly associated with the risk of ASD. The underlying mechanism of the aberrant expression of GABRB3 gene in ASD patients should be investigated in other biological levels.

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Funding

This study was supported financially by Shahid Beheshti University of Medical Sciences.

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Authors and Affiliations

  1. Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Rezvan Noroozi, Mohammad Taheri, Soudeh Ghafouri-Fard & Mir Davood Omrani

  2. Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Rezvan Noroozi

  3. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Taheri & Mir Davood Omrani

  4. Sabzevar University of Medical Sciences, The Collaboration Center of Meta-Analysis Research (ccMETA), Tehran, Iran

    Zeinab Bidel

  5. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Ali Sanjari Moghaddam

  6. Deputy of Research and Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Parisa Sarabi

  7. Department of Social Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Alireza Mosavi Jarahi

Authors
  1. Rezvan Noroozi
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  2. Mohammad Taheri
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  3. Soudeh Ghafouri-Fard
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  4. Zeinab Bidel
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  5. Mir Davood Omrani
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  6. Ali Sanjari Moghaddam
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  7. Parisa Sarabi
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  8. Alireza Mosavi Jarahi
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Corresponding authors

Correspondence to Mohammad Taheri or Alireza Mosavi Jarahi.

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The authors declare that they have no conflict of interest.

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Noroozi, R., Taheri, M., Ghafouri-Fard, S. et al. Meta-analysis of GABRB3 Gene Polymorphisms and Susceptibility to Autism Spectrum Disorder. J Mol Neurosci 65, 432–437 (2018). https://doi.org/10.1007/s12031-018-1114-2

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  • DOI: https://doi.org/10.1007/s12031-018-1114-2

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