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Quality of life in patients with hypoparathyroidism receiving standard treatment: a systematic review

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Abstract

Purpose

Hypoparathyroidism is a rare endocrine disorder for which replacement therapy of the missing parathyroid hormone is not the standard therapeutic option. Current standard treatment consists of calcium and vitamin D supplementation. The intake of calcium and vitamin D supplementation can lead to complications and therefore might negatively influence patients’ quality of life.

Methods

A systematic literature review was performed to assess the current knowledge on the influence of hypoparathyroidism on patients’ quality of life. The literature search was conducted in PubMed and Web of Science; all relevant literature published by August 24, 2016, was included.

Results

In total 372 records were found. After title and abstract screening, 14 studies remained for a full-text screening. The full-text screening resulted in five studies which were included into the systematic review. Comparing the results with a norm-based reference population, three studies reported lower SF-36 scores for hypoparathyroidism patients. Two studies showed a reduced quality of life in hypoparathyroidism patients when their results were compared to control populations.

Conclusion

Most hypoparathyroidism patients receiving standard treatment show stable calcium and vitamin D levels. However, hypoparathyroidism patients still report reduced quality of life and experience physical, mental, and emotional symptoms. Therefore, it is assumed that the lack of parathyroid hormone directly influences the patients’ quality of life. This review indicates that patients with hypoparathyroidism have a reduced quality of life in comparison to norm-based populations or matched controls. Further studies are required to quantify the effect of hypoparathyroidism on patients’ quality of life using disease-specific questionnaires and controlling for the co-morbidities and etiologies of the patients.

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Acknowledgements

Authors’ roles: All authors contributed to the conception and design of the study. All authors contributed to the acquisition, analysis and interpretation of the data. All authors participated in drafting or critically revising the manuscript and all authors’ approved the final version of the manuscript for submission.

Funding

This study did not receive any funding or grants.

Author information

Authors and Affiliations

  1. Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), Division of Epidemiology and Health Services Research, University Medical Center Mainz, Obere Zahlbacher Straße 69, 55131, Mainz, Germany

    Matthias Büttner & Susanne Singer

  2. University Cancer Centre, Mainz, Germany

    Matthias Büttner & Susanne Singer

  3. Department of Surgery, University Medical Center Mainz, Building 505, Langenbeckstr. 1, 55131, Mainz, Germany

    Thomas J. Musholt

Authors
  1. Matthias Büttner
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  2. Thomas J. Musholt
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  3. Susanne Singer
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Correspondence to Matthias Büttner.

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Conflict of interest

Matthias Buettner has nothing to disclose. Thomas Musholt has nothing to disclose. Susanne Singer reports grants from Pfitzer, outside the submitted work.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Büttner, M., Musholt, T.J. & Singer, S. Quality of life in patients with hypoparathyroidism receiving standard treatment: a systematic review. Endocrine 58, 14–20 (2017). https://doi.org/10.1007/s12020-017-1377-3

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  • DOI: https://doi.org/10.1007/s12020-017-1377-3

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