Skip to main content
SpringerLink
Log in

Molecular signatures define myogenic stem cell populations

  • Original Article
  • Published:
Stem Cell Reviews Aims and scope Submit manuscript

Abstract

Developmental and regenerative mechanisms are directed by stem cell populations. Skeletal muscle is a dynamic tissue that is capable of adapting to stress and severe injury due to a resident somatic stem cell population. In response to a severe injury that destroys upward of 90% of the tissue, skeletal muscle efficiently and reproducibly regenerates damaged tissue and restores the cellular architecture within a 2-wk period. Recent studies have localized and examined the molecular regulation of skeletal muscle stem cell populations using emerging molecular biological technologies. These studies enhance the understanding of the regulatory mechanisms that direct the somatic stem cell populations and the role they play in development and regeneration. Furthermore, these basic science studies will serve as a platform for future therapies directed toward patients with myopathic diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hawke T, Garry DJ. J Appl Physiol 2001;91:534–551.

    PubMed  CAS  Google Scholar 

  2. Cossu G, Mavilio F, J. Clin Invest 2000;105(12):1669–1674.

    Article  PubMed  CAS  Google Scholar 

  3. Garry DJ, Yang Q, Bassel-Duby R, Williams RS, Dev Biol 1997;188:280–294.

    Article  PubMed  CAS  Google Scholar 

  4. Garry DJ, Meeson A, Elterman J, et al. PNAS 2000;97 (10): 5416–5421.

    Article  PubMed  CAS  Google Scholar 

  5. Cornelison DD, Wilcox-Adelman SA, Goetinck PF, Rauvala H, Rapraeger AC, Olwin, BB Genes and Dev 2004:18:2231–2236.

    Article  PubMed  CAS  Google Scholar 

  6. Seale P, Sabourin LA, Girgis-Gabardo A, Mansouri A, Gruss P, Rudnicki MA, Cell 2000;102:777–786.

    Article  PubMed  CAS  Google Scholar 

  7. Goetsch SC, Martin CM, Embree LJ, Garry DJ. Stem Cells and Dev 2005;2:181–187.

    Article  Google Scholar 

  8. Goetsch SC, Hawke TJ, Gallardo TD, Richardson JA, Garry DJ, Phsyiol Genomics 2003;14:261–271.

    CAS  Google Scholar 

  9. Ruiz C, Huang W, Hegi ME, et al. Cancer Res 2004;64:7377–7385.

    Article  PubMed  CAS  Google Scholar 

  10. Harty M, Neff AW, King MW, Mescher AL. Dev Dyn 2003;226:268–279.

    Article  PubMed  Google Scholar 

  11. Cossu G, Histol Histopathol 1997;12:755–760.

    PubMed  CAS  Google Scholar 

  12. Relaix F, Rocancourt D, Mansouri A, Buckingham MA, Nature 2005;435:948–953.

    Article  PubMed  CAS  Google Scholar 

  13. Fuchs E, Segre JA. Cell 2000;100:143–155.

    Article  PubMed  CAS  Google Scholar 

  14. Weissman IL, Cell 2000;100:157–168.

    Article  PubMed  CAS  Google Scholar 

  15. Blau JM, Brazelton TR, Weimann JM. Cell 2001;105:829–841.

    Article  PubMed  CAS  Google Scholar 

  16. Conboy IM, Conboy MJ, Wager AJ, Girma ER, Weissman IL, Rando TA. Nature 2005;433:760–764.

    Article  PubMed  CAS  Google Scholar 

  17. Goodell M, Brose K, Paradis G, Conner A, Mulligan R. J Exp Med 1996;183:1797–1806.

    Article  PubMed  CAS  Google Scholar 

  18. Goodell M, Rosenzweig M, Kim H, et al.. Nature Med 1997;3:12: 1337–1345.

    Article  PubMed  CAS  Google Scholar 

  19. Gussoni E, Soneoka Y, Strickland C, et al. Nature 1999;401: 390–394.

    PubMed  CAS  Google Scholar 

  20. Bunting K. Stem Cells 2002;20:11–20.

    Article  PubMed  CAS  Google Scholar 

  21. Zhou SJ, Schuetz K, Bunting A, et al. Nature Med 2001;7:9: 1028–1034.

    Article  PubMed  CAS  Google Scholar 

  22. Martin CM, Meeson AP, Robertson SM, et al., Dev Biol 2004:265: 262–275.

    Article  PubMed  CAS  Google Scholar 

  23. Litman T, Druley T, Stein W, Bates S. Cell Mol. Life Sci 2001;58: 931–959.

    Article  PubMed  CAS  Google Scholar 

  24. Krishnamurthy P, Ross DD, Nakanishi T, et al. J Biol Chem 2004; 27:24,218–24,225.

    Google Scholar 

  25. Weigel D., Seifert E, Reuter D, Jackle H. EMBO J 1990;9:1199–1207.

    PubMed  CAS  Google Scholar 

  26. Weigel D, Jurgens G, Kuttner F, Seifert E, Jackle H. Cell 1989;57:645–658.

    Article  PubMed  CAS  Google Scholar 

  27. Lai E, Clark KL, Burley S, Darnell JE, PNAS 1993;90: 10,421–10,423.

    CAS  Google Scholar 

  28. Ang S-L, Rossant J. Cell 1994;78:561–574.

    Article  PubMed  CAS  Google Scholar 

  29. Weinstein D, Altaba A, Chen W. et al., Cell 1994;78:575–588.

    Article  PubMed  CAS  Google Scholar 

  30. Sutton J, Costa R, Klug M, et al. J Biol Chem 1996;271: 23,126–23,133.

    CAS  Google Scholar 

  31. Ye H, Kelly T, Samadani U, et al. Mol Cell Biol 1997;17: 1626–1641.

    PubMed  CAS  Google Scholar 

  32. Hawke TJ, Jiang N, Garry DJ, J Biol Chem 2003;278:4015–4020.

    Article  PubMed  CAS  Google Scholar 

  33. Hawke TJ, Meeson A, Jiang N, et al., Am J Physiol 2003;285: C1019-C1027.

    CAS  Google Scholar 

  34. Meeson AP, Hawke TJ, Graham S et al. Stem Cells 2004;22: 1305–1320.

    Article  PubMed  CAS  Google Scholar 

  35. Gallardo TD, Hammer RE, Garry DJ. Genesis 2003:37:57–63.

    Article  PubMed  CAS  Google Scholar 

  36. Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA. Science 2002;298:597–600.

    Article  PubMed  CAS  Google Scholar 

  37. Ivanova NB, Dimos JT, Schaniel C, Hackney JA, Moore KA, Lemischka IR. Science 2002;298:601–604.

    Article  PubMed  CAS  Google Scholar 

  38. Polesskaya A, Seale P, Rudnicki MA. Cell 2003;113:841–852.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine at UT Southwestern Medical Center, NB11, 118A, 5323 Harry Hines Blvd., 75390, Dallas, TX

    Cindy M. Martin, Jamie L. Russell, Anwarul Ferdous & Daniel J. Garry

  2. Department of Molecular Biology at UT Southwestern Medical Center, NB11.118A, 5323 Harry Hines Blvd, 75390, Dallas, TX

    Daniel J. Garry

  3. Donald W. Reynolds Cardiovascular Clinical Research Center at UT Southwestern Medical Center, NB11, 118A, 5323 Harry Hines Blvd, 75390, Dallas, TX

    Daniel J. Garry

Authors
  1. Cindy M. Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jamie L. Russell
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anwarul Ferdous
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Daniel J. Garry
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Daniel J. Garry.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Martin, C.M., Russell, J.L., Ferdous, A. et al. Molecular signatures define myogenic stem cell populations. Stem Cell Rev 2, 37–42 (2006). https://doi.org/10.1007/s12015-006-0007-x

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12015-006-0007-x

Index Entries

Search

Navigation