Abstract
Purpose of Review
From health systems to individuals, nephrolithiasis is economically burdensome. The aim of the current paper is to characterize the financial burden of disease associated with nephrolithiasis with an emphasis on investigating treatment modality economic efficiency.
Recent Findings
For small volume practices and cases where there is high risk of scope damage, disposable flexible ureteroscope utilization seems to provide economic efficiency.
Summary
The rise in global prevalence of stone disease is a large contributing factor to increasing costs associated with nephrolithiasis. A large proportion of costs from kidney stones stem from ED visits and inpatient care. There are opportunities to save money by transitioning care to outpatient settings in scenarios that allow such transition. Metaphylaxis and prevention strategies are effective at lowering costs in properly selected patient populations. Flexible ureteroscopy and percutaneous nephrolithotomy (PCNL) are the most economically efficient methods of surgically treating stone disease, with PCNL being reserved for large and lower pole stones. Time off work and other indirect costs, while challenging to quantify, are important considerations in the economics of nephrolithiasis.
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References
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Pearle MS, Calhoun EA, Curhan GC. Urologic Diseases of America P. Urologic diseases in America project: urolithiasis. J Urol. 2005;173(3):848–57.
Kelly C, Geraghty RM, Somani BK. Nephrolithiasis in the obese patient. Curr Urol Rep. 2019;20(7):36.
Clark JY. Renal calculi in army aviators. Aviat Space Environ Med. 1990;61(8):744–7.
Bansal AD, Hui J, Goldfarb DS. Asymptomatic nephrolithiasis detected by ultrasound. Clin J Am Soc Nephrol. 2009;4(3):680–4.
Boyce CJ, Pickhardt PJ, Lawrence EM, Kim DH, Bruce RJ. Prevalence of urolithiasis in asymptomatic adults: objective determination using low dose noncontrast computerized tomography. J Urol. 2010;183(3):1017–21.
Ziemba JB, Matlaga BR. Epidemiology and economics of nephrolithiasis. Investig Clin Urol. 2017;58(5):299–306.
Scales CD Jr, Smith AC, Hanley JM, Saigal CS. Urologic Diseases in America P. Prevalence of kidney stones in the United States. Eur Urol. 2012;62(1):160–5.
Tasian GE, Ross ME, Song L, Sas DJ, Keren R, Denburg MR, et al. Annual incidence of nephrolithiasis among children and adults in South Carolina from 1997 to 2012. Clin J Am Soc Nephrol. 2016;11(3):488–96.
•• Kittanamongkolchai W, Vaughan LE, Enders FT, Dhondup T, Mehta RA, Krambeck AE, et al. The changing incidence and presentation of urinary stones over 3 decades. Mayo Clin Proc. 2018;93(3):291–9. Highlights important, contemporary epidemiological trends in stone disease.
Balthazar P, Sadigh G, Hughes D, Rosenkrantz AB, Hanna T, Duszak R Jr. Increasing use, geographic variation, and disparities in emergency department CT for suspected urolithiasis. J Am Coll Radiol. 2019;16(11):1547–53.
Luckenbaugh AN, Yan PL, Dauw CA, Ghani KR, Hollenbeck BK, Hollingsworth JM. Followup care after emergency department visits for kidney stones: a missed opportunity. Urol Pract. 2019;6(1):24–8.
Scales CD Jr, Lin L, Saigal CS, Bennett CJ, Ponce NA, Mangione CM, et al. Emergency department revisits for patients with kidney stones in California. Acad Emerg Med. 2015;22(4):468–74.
Fan B, Yang D, Wang J, Che X, Li X, Wang L, et al. Can tamsulosin facilitate expulsion of ureteral stones? A meta-analysis of randomized controlled trials. Int J Urol. 2013;20(8):818–30.
Bensalah K, Pearle M, Lotan Y. Cost-effectiveness of medical expulsive therapy using alpha-blockers for the treatment of distal ureteral stones. Eur Urol. 2008;53(2):411–8.
Hollingsworth JM, Norton EC, Kaufman SR, Smith RM, Wolf JS Jr, Hollenbeck BK. Medical expulsive therapy versus early endoscopic stone removal for acute renal colic: an instrumental variable analysis. J Urol. 2013;190(3):882–7.
Lotan Y, Pearle MS. Cost-effectiveness of primary prevention strategies for nephrolithiasis. J Urol. 2011;186(2):550–5.
Lotan Y, Buendia Jimenez I, Lenoir-Wijnkoop I, Daudon M, Molinier L, Tack I, et al. Primary prevention of nephrolithiasis is cost-effective for a national healthcare system. BJU Int. 2012;110(11 Pt C):E1060–7.
Lotan Y. Economics and cost of care of stone disease. Adv Chronic Kidney Dis. 2009;16(1):5–10.
Pearle MS, Goldfarb DS, Assimos DG, Curhan G, Denu-Ciocca CJ, Matlaga BR, et al. Medical management of kidney stones: AUA guideline. J Urol. 2014;192(2):316–24.
Chandhoke PS. When is medical prophylaxis cost-effective for recurrent calcium stones? J Urol. 2002;168(3):937–40.
Lotan Y, Cadeddu JA, Roerhborn CG, Pak CY, Pearle MS. Cost-effectiveness of medical management strategies for nephrolithiasis. J Urol. 2004;172(6 Pt 1):2275–81.
Lotan Y, Cadeddu JA, Pearle MS. International comparison of cost effectiveness of medical management strategies for nephrolithiasis. Urol Res. 2005;33(3):223–30.
Strohmaier WL. Economic aspects of evidence-based metaphylaxis. Urol A. 2006;45(11):1406–9.
Strohmaier WL. Socioeconomic aspects of urinary calculi and metaphylaxis of urinary calculi. Urol A. 2000;39(2):166–70.
Strohmaier WL. Economics of stone disease/treatment. Arab J Urol. 2012;10(3):273–8.
Borghi L, Schianchi T, Meschi T, Guerra A, Allegri F, Maggiore U, et al. Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. N Engl J Med. 2002;346(2):77–84.
Taylor EN, Fung TT, Curhan GC. DASH-style diet associates with reduced risk for kidney stones. J Am Soc Nephrol. 2009;20(10):2253–9.
Pauly MV, Burns LR. Price transparency for medical devices. Health Aff (Millwood). 2008;27(6):1544–53.
Robinson JC. Value-based purchasing for medical devices. Health Aff (Millwood). 2008;27(6):1523–31.
Landman J, Lee DI, Lee C, Monga M. Evaluation of overall costs of currently available small flexible ureteroscopes. Urology. 2003;62(2):218–22.
Collins JW, Keeley FX Jr, Timoney A. Cost analysis of flexible ureterorenoscopy. BJU Int. 2004;93(7):1023–6.
Gurbuz C, Atis G, Arikan O, Efilioglu O, Yildirim A, Danacioglu O, et al. The cost analysis of flexible ureteroscopic lithotripsy in 302 cases. Urolithiasis. 2014;42(2):155–8.
Somani BK, Robertson A, Kata SG. Decreasing the cost of flexible ureterorenoscopic procedures. Urology. 2011;78(3):528–30.
User HM, Hua V, Blunt LW, Wambi C, Gonzalez CM, Nadler RB. Performance and durability of leading flexible ureteroscopes. J Endourol. 2004;18(8):735–8.
Antonelli JA. Innovations in surgical stone disease. Curr Opin Urol. 2016;26(3):240–7.
Isaacson D, Ahmad T, Metzler I, Tzou DT, Taguchi K, Usawachintachit M, et al. Defining the costs of reusable flexible ureteroscope reprocessing using time-driven activity-based costing. J Endourol. 2017;31(10):1026–31.
Kramolowsky E, McDowell Z, Moore B, Booth B, Wood N. Cost analysis of flexible ureteroscope repairs: evaluation of 655 procedures in a community-based practice. J Endourol. 2016;30(3):254–6.
Tosoian JJ, Ludwig W, Sopko N, Mullins JK, Matlaga BR. The effect of repair costs on the profitability of a ureteroscopy program. J Endourol. 2015;29(4):406–9.
Sung JC, Springhart WP, Marguet CG, L'Esperance JO, Tan YH, Albala DM, et al. Location and etiology of flexible and semirigid ureteroscope damage. Urology. 2005;66(5):958–63.
Monga M, Best S, Venkatesh R, Ames C, Lee C, Kuskowski M, et al. Durability of flexible ureteroscopes: a randomized, prospective study. J Urol. 2006;176(1):137–41.
Carey RI, Gomez CS, Maurici G, Lynne CM, Leveillee RJ, Bird VG. Frequency of ureteroscope damage seen at a tertiary care center. J Urol. 2006;176(2):607–10 discussion 10.
Defidio L, De Dominicis M, Di Gianfrancesco L, Fuchs G, Patel A. Improving flexible ureterorenoscope durability up to 100 procedures. J Endourol. 2012;26(10):1329–34.
Multescu R, Geavlete B, Georgescu D, Geavlete P. Improved durability of flex-Xc digital flexible ureteroscope: how long can you expect it to last? Urology. 2014;84(1):32–5.
•• Martin CJ, SB MA, Abdul-Muhsin H, Lim VM, Nunez-Nateras R, Tyson MD, et al. The economic implications of a reusable flexible digital ureteroscope: a cost-benefit analysis. J Urol. 2017;197(3 Pt 1):730–5. Disposable flexible ureteroscopes are most economically beneficial at centers with low case volume, yet are valuable in high volume centers when cases pose a high risk of damage to the scope.
• Hennessey DB, Fojecki GL, Papa NP, Lawrentschuk N, Bolton D. Single-use disposable digital flexible ureteroscopes: an ex vivo assessment and cost analysis. BJU Int. 2018;121(Suppl 3):55–61. The LithoVue disposable ureteroscope device is equivalent to reusable ureteroscopes by technical standards and purchase price is the most important determinant of the economic benefit of disposable scopes.
Ozimek T, Schneider MH, Hupe MC, Wiessmeyer JR, Cordes J, Chlosta PL, et al. Retrospective cost analysis of a single-center reusable flexible ureterorenoscopy program: a comparative cost simulation of disposable fURS as an alternative. J Endourol. 2017;31(12):1226–30.
• Taguchi K, Usawachintachit M, Tzou DT, Sherer BA, Metzler I, Isaacson D, et al. Micro-costing analysis demonstrates comparable costs for LithoVue compared to reusable flexible fiberoptic ureteroscopes. J Endourol. 2018;32(4):267–73. Acquisition costs of disposable ureteroscopes are higher, yet savings are realized in the areas of maintenance, labor, and consumables. The cost per case of using a disposable and a reusable ureteroscope are very similar.
Al-Balushi K, Martin N, Loubon H, Baboudjian M, Michel F, Sichez PC, et al. Comparative medico-economic study of reusable vs. single-use flexible ureteroscopes. Int Urol Nephrol. 2019;51(10):1735–41.
Preminger GM, Assimos DG, Lingeman JE, Nakada SY, Pearle MS, Wolf JS Jr, et al. Chapter 1: AUA guideline on management of staghorn calculi: diagnosis and treatment recommendations. J Urol. 2005;173(6):1991–2000.
Kim SC, Kuo RL, Lingeman JE. Percutaneous nephrolithotomy: an update. Curr Opin Urol. 2003;13(3):235–41.
Koo V, Beattie I, Young M. Improved cost-effectiveness and efficiency with a slower shockwave delivery rate. BJU Int. 2010;105(5):692–6.
Lotan Y, Pearle MS. Economics of stone management. Urol Clin North Am. 2007;34(3):443–53.
Hyams ES, Shah O. Percutaneous nephrostolithotomy versus flexible ureteroscopy/holmium laser lithotripsy: cost and outcome analysis. J Urol. 2009;182(3):1012–7.
Akman T, Binbay M, Akcay M, Tekinarslan E, Kezer C, Ozgor F, et al. Variables that influence operative time during percutaneous nephrolithotomy: an analysis of 1897 cases. J Endourol. 2011;25(8):1269–73.
Tanriverdi O, Boylu U, Kendirci M, Kadihasanoglu M, Horasanli K, Miroglu C. The learning curve in the training of percutaneous nephrolithotomy. Eur Urol. 2007;52(1):206–11.
Raman JD, Bagrodia A, Bensalah K, Pearle MS, Lotan Y. Residual fragments after percutaneous nephrolithotomy: cost comparison of immediate second look flexible nephroscopy versus expectant management. J Urol. 2010;183(1):188–93.
May DJ, Chandhoke PS. Efficacy and cost-effectiveness of extracorporeal shock wave lithotripsy for solitary lower pole renal calculi. J Urol. 1998;159(1):24–7.
Lotan Y, Gettman MT, Roehrborn CG, Cadeddu JA, Pearle MS. Management of ureteral calculi: a cost comparison and decision making analysis. J Urol. 2002;167(4):1621–9.
Huang CY, Chen SS, Chen LK. Cost-effectiveness of treating ureteral stones in a Taipei City Hospital: shock wave lithotripsy versus ureteroscopy plus lithoclast. Urol Int. 2009;83(4):410–5.
Parker BD, Frederick RW, Reilly TP, Lowry PS, Bird ET. Efficiency and cost of treating proximal ureteral stones: shock wave lithotripsy versus ureteroscopy plus holmium:yttrium-aluminum-garnet laser. Urology. 2004;64(6):1102–6 discussion 6.
Izamin I, Aniza I, Rizal AM, Aljunid SM. Comparing extracorporeal shock wave lithotripsy and ureteroscopy for treatment of proximal ureteric calculi: a cost-effectiveness study. Med J Malaysia. 2009;64(1):12–21.
Wu CF, Chen CS, Lin WY, Shee JJ, Lin CL, Chen Y, et al. Therapeutic options for proximal ureter stone: extracorporeal shock wave lithotripsy versus semirigid ureterorenoscope with holmium:yttrium-aluminum-garnet laser lithotripsy. Urology. 2005;65(6):1075–9.
Bierkens AF, Hendrikx AJ, De La Rosette JJ, Stultiens GN, Beerlage HP, Arends AJ, et al. Treatment of mid- and lower ureteric calculi: extracorporeal shock-wave lithotripsy vs laser ureteroscopy. A comparison of costs, morbidity and effectiveness. Br J Urol. 1998;81(1):31–5.
Wolf JS Jr, Carroll PR, Stoller ML. Cost-effectiveness v patient preference in the choice of treatment for distal ureteral calculi: a literature-based decision analysis. J Endourol. 1995;9(3):243–8.
Chang CP, Huang SH, Tai HL, Wang BF, Yen MY, Huang KH, et al. Optimal treatment for distal ureteral calculi: extracorporeal shockwave lithotripsy versus ureteroscopy. J Endourol. 2001;15(6):563–6.
Matlaga BR, Jansen JP, Meckley LM, Byrne TW, Lingeman JE. Economic outcomes of treatment for ureteral and renal stones: a systematic literature review. J Urol. 2012;188(2):449–54.
Curhan GC. Epidemiology of stone disease. Urol Clin North Am. 2007;34(3):287–93.
Resnick MI, Persky L. Summary of the National Institutes of Arthritis, Diabetes, Digestive and Kidney Diseases conference on urolithiasis: state of the art and future research needs. J Urol. 1995;153(1):4–9.
Saigal CS, Joyce G, Timilsina AR. Urologic Diseases in America P. Direct and indirect costs of nephrolithiasis in an employed population: opportunity for disease management? Kidney Int. 2005;68(4):1808–14.
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Roberson, D., Sperling, C., Shah, A. et al. Economic Considerations in the Management of Nephrolithiasis. Curr Urol Rep 21, 18 (2020). https://doi.org/10.1007/s11934-020-00971-6
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DOI: https://doi.org/10.1007/s11934-020-00971-6