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Sleep Problems in Children with Attention Deficit/Hyperactivity Disorder: Current Status of Knowledge and Appropriate Management

  • Sleep Disorders (P Gehrman, Section Editor)
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Abstract

Attention deficit hyperactivity disorder (ADHD) affects approximately 5 % of children and adolescents, and sleep problems are common in these patients. There is growing evidence informing the significant importance of sleep problems in youth with ADHD. The sleep problems in children with ADHD include specific sleep disorders and sleep disturbances due to comorbid psychiatric disorders or ADHD medications. The specific sleep disorders of ADHD children include behaviorally based insomnia, sleep-disordered breathing, and restless legs syndrome/periodic limb movement disorder. Current practices on the management of sleep problems for ADHD children are based mostly on expert consensus, whereas more evidence-based literature can be found only recently. Assessment of the sleep conditions in ADHD children before initiation of pharmacotherapy is the currently recommended guideline, and good sleep hygiene can be considered as the first-line treatment option. In addition to modifying the dose regimens, formulation, or alternative stimulants when sleep problems are encountered in ADHD children, atomoxetine, once daily guanfacine extended release, and melatonin are potential choices for ADHD children with more severe sleep problems. In this review, we aimed to provide the most updated information, preferably based on meta-analyses, systemic review, and randomized controlled trials published in the latest 3 years, in order to be clinically useful for practitioners and clinicians.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance, •• Of major importance

  1. Sung V, Hiscock H, Sciberras E, Efron D. Sleep problems in children with attention-deficit/hyperactivity disorder: prevalence and the effect on the child and family. Arch Pediatr Adolesc Med. 2008;162:336–42.

    Article  PubMed  Google Scholar 

  2. Um YH, Jeong JH, Hong SC, Kim TW, Lim HK, Seo HJ, et al. Association between sleep parameters and cognitive function in drug-naïve children with attention-deficit hyperactivity disorder: a polysomnographic study. Sleep Med. doi:10.1016/j.sleep.2015.11.016. This study documented the relationship between sleep parameters and cognitive function in drug-naïve children with ADHD, while most subjects in previous studies were on medication, which is a potent confounding factor.

  3. Mulraney M, Giallo R, Lycett K, Mensah F, Sciberras E. The bidirectional relationship between sleep problems and internalizing and externalizing problems in children with ADHD: a prospective cohort study. Sleep Med. 2016;17:45–51.

    Article  PubMed  Google Scholar 

  4. Katzman MA, Sternat T. A review of OROS methylphenidate (Concerta®) in the treatment of attention-deficit/hyperactivity disorder. CNS Drugs. 2014;28:1005–33.

    Article  CAS  PubMed  Google Scholar 

  5. Becker SP, Pfiffner LJ, Stein MA, Burns GL, McBurnett K. Sleep habits in children with attention-deficit/hyperactivity disorder predominantly inattentive type and associations with comorbid psychopathology symptoms. Sleep Med. 2015;11:S1389–9457.

    Google Scholar 

  6. Canals J, Morales-Hidalgo P, Jané MC, Domènech E. ADHD prevalence in Spanish preschoolers: comorbidity, socio-demographic factors, and functional consequences. J Atten Disord. 2016. doi:10.1177/1087054716638511.

  7. Yallop L, Brownell M, Chateau D, Walker J, Warren M, Baillis D, et al. Lifetime prevalence of attention-deficit/hyperactivity disorder in young adults: examining variations in the socioeconomic gradient. Can J Psychiatry. 2015;60:432–40.

    PubMed  PubMed Central  Google Scholar 

  8. Wang KY. Updated findings on neurodevelopmental disorders in Taiwan: impact of the institutionalized national healthcare system on prevalence and health outcomes. Curr Opin Psychiatry. 2016;29:144–8.

    Article  PubMed  Google Scholar 

  9. Aquirre Castaneda RL, Kumar S, Voigt RG, Leibson CL, Barbaresi WJ, et al. Childhood attention-deficit/hyperactivity disorder, sex, and obesity: a longitudinal population-based study. Mayo Clin Proc. 2016;91:352–61.

    Article  Google Scholar 

  10. van Lieshout M, Luman M, Twisk JW, van Ewijk H, Groenman AP, Thissen AJ, et al. A 6-year follow-up of a large European cohort of children with attention-deficity/hyperactivity disorder-combined subtype: outcomes in late adolescence and young adulthood. Eur Child Adolesc Psychiatry. 2016. doi:10.1007/s00787-016-0820-y.

  11. Casas M, Rösler M, Sandra Kooij JJ, Ginsberg Y, Ramos-Quiroga JA, Heger S, et al. Efficacy and safety of prolonged-release OROS methylphenidate in adults with attention-deficit/hyperactivity disorder: a 13-week, randomized, double-blind, placebo-controlled, fixed-dose study. World J Biol Psychiatry. 2013;14:268–81.

    Article  PubMed  Google Scholar 

  12. Rönnlund H, Elovainio M, Virtanen I, Matomäki J, Lapinleimu H. Poor parental sleep and the reported sleep quality of their children. Pediatrics. 2016. doi:10.1542/peds.2015-3425.

  13. Kronholm E, Puusniekka R, Jokela J, Villberg J, Urrila AS, Paunio T, et al. Trends in self-reported sleep problems, tiredness and related school performance among Finnish adolescents from 1984 to 2011. J Sleep Res. 2015;24:3–10.

    Article  PubMed  Google Scholar 

  14. Hysing M, Pallesen S, Stormark KM, Lundervold AJ, Sivertsen B. Sleep patterns and insomnia among adolescents: a population-based study. J Sleep Res. 2013;22:549–56.

    Article  PubMed  Google Scholar 

  15. Efron D, Lycett K, Sciberras E. Use of sleep medication in children with ADHD. Sleep Med. 2014;15:472–5.

    Article  PubMed  Google Scholar 

  16. Corkum P, Davidson F, MacPherson M. A framework for the assessment and treatment of sleep problems in children with attention-deficit/hyperactivity disorder. Pediatr Clin N Am. 2011;58:667–83.

    Article  Google Scholar 

  17. Cortese S, Lecendreux M, Mouren MC, Konofal E. ADHD and insomnia. J Am Acad Child Adolesc Psychiatry. 2006;45:384–5.

    Article  PubMed  Google Scholar 

  18. Mitchison GM, Njardvik U. Prevalence and gender differences of ODD, anxiety, and depression in a sample of children with ADHD. J Atten Disord. 2015. doi:10.1177/1087054715608442.

  19. Lee MJ, Yang KC, Shyu YC, Yuan SS, Yang CJ, Lee SY, et al. Attention-deficit hyperactivity disorder, its treatment with medication and the probability of developing a depressive disorder: a nationwide population-based study in Taiwan. J Affect Disord. 2016;189:110–7.

    Article  PubMed  Google Scholar 

  20. Spruyt K, Gozal D. Sleep disturbances in children with attention-deficit/hyperactivity disorder. Expert Rev Neurother. 2011;11:565–77.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Sciberras E, Lycett K, Efron D, Mensah F, Gerner B, Hiscock H. Anxiety in children with attention-deficit/hyperactivity disorder. Pediatrics. 2014;133:801–8.

    Article  PubMed  Google Scholar 

  22. Kidwell KM, Van Dyk TR, Lundahl A, Nelson TD. Stimulant medications and sleep for youth with ADHD: a meta-analysis. Pediatrics. 2015;136:1144–53. This is a recent published meta-analysis of stimulant medication regarding its effects of longer sleep latency, worse sleep efficiency, and shorter sleep duration.

    Article  PubMed  Google Scholar 

  23. Santisteban JA, Stein MA, Bergmame L, Gruber R. Effect of extended-release dexmethylphenidate and mixed amphetamine salts on sleep: a double-blind, randomized, crossover study in youth with attention-deficit hyperactivity disorder. CNS Drugs. 2014;28:825–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. LeBourgeois MK, Giannotti F, Cortesi F, Wolfson AR, Harsh J. The relationship between reported sleep quality and sleep hygiene in Italian and American adolescents. Pediatrics. 2005;115:257–65.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Meltzer LJ, Brimeyer C, Russell K, Avis KT, Biggs S, Reynolds AC, et al. The children’s report of sleep patterns: validity and reliability of the sleep hygiene index and sleep disturbance scale in adolescents. Sleep Med. 2014;15:1500–7.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Weiss MD, Salpekar J. Sleep problems in the child with attention-deficit/hyperactivity disorder: defining etiology and appropriate treatments. CNS Drugs. 2010;24:811–28.

    Article  CAS  PubMed  Google Scholar 

  27. Sciberras E, Fulton M, Efron D, Oberklaid F, Hiscock H. Managing sleep problems in school aged children with ADHD: a pilot randomized controlled trial. Sleep Med. 2011;12:932–5.

    Article  PubMed  Google Scholar 

  28. Hiscock H, Sciberras E, Mensah F, Gerner B, Efron D, Khano S, et al. Impact of a behavioral sleep intervention on symptoms and sleep in children with attention-deficit/hyperactivity disorder, and parental mental health: randomized controlled trial. BMJ. 2015;350:h68. This study providing evidence-based information using RCT documenting the effect of behavior sleep intervention on ADHD children with sleep problems.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Vidal R, Castells J, Richarte V, Palomar G, Garcia M, Nicolau R, et al. Group therapy for adolescents with attention-deficit/hyperactivity disorder: a randomized controlled trial. J Am Acad Child Adolesc Psychiatry. 2015;54:275–82. This study is the latest and an important RCT documenting the effect of group therapy for adolescents with ADHD.

    Article  PubMed  Google Scholar 

  30. Santisteban JA, Stein MA, Bergmame L, Gruber R. Effect of extended-release dexmethylphenidate and mixed amphetamine salts on sleep: a double-blind, randomized, crossover study in youth with attention-deficit hyperactivity disorder. CNS Drugs. 2014;28:825–33. This study highlights that higher stimulant doses are associated with reduced sleep duration and later sleep start times, regardless of medication class.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Bock DE, Roach-Fox E, Seabrook JA, Rieder MJ, Matsui D. Sleep-promoting medications in children: physician prescribing habits in Southwestern Ontario. Canada Sleep Med. 2016;17:52–6.

    Article  PubMed  Google Scholar 

  32. Golmirzaei J, Mahboobi H, Yazdanparast M, Mushtag G, Kamal MA, Hamzei E. Psychopharmacology of attention-deficit hyperactivity disorder: effects and side effects. Curr Pharm Des. 2016;22:590–4.

    Article  CAS  PubMed  Google Scholar 

  33. Furster C, Hallerbäck MU. The use of melatonin in Swedish children and adolescents—a register-based study according to age, gender, and medication of ADHD. Eur J Clin Pharmacol. 2015;71:877–81.

    Article  CAS  PubMed  Google Scholar 

  34. Dalsgaard S, Nielsen HS, Simonsen M. Five-fold increase in national prevalence rates of attention-deficit/hyperactivity disorder medications for children and adolescents with autism spectrum disorder, attention-deficit/hyperactivity disorder, and other psychiatric disorders: a Danish register-based study. J Child Adolesc Psychopharmacol. 2013;23:432–9.

    Article  PubMed  PubMed Central  Google Scholar 

  35. van der Heijden KB, Smits MG, Van Someren EJ, Gunning WB. Idiopathic chronic sleep onset insomnia in attention-deficit/hyperactivity disorder: a circadian rhythm sleep disorder. Chronobiol Int. 2005;22:559–70.

    Article  PubMed  Google Scholar 

  36. van Geijlswijk IM, Korzilius HP, Smits MG. The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep. 2010;33:1605–14.

    PubMed  PubMed Central  Google Scholar 

  37. Bendz LM, Scates AC. Melatonin treatment for insomnia in pediatric patients with attention-deficit/hyperactivity disorder. Ann Pharmacother. 2010;44:185–91.

    Article  CAS  PubMed  Google Scholar 

  38. Gringras P, Gamble C, Jones AP, Wiggs L, Williamson PR, Sutcliffe A, et al. Melatonin for sleep problems in children with neurodevelopmental disorders: randomized double masked placebo controlled trial. BMJ. 2012;345:e6664.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Hoebert M, van der Heijden KB, van Geijlswijk IM, Smits MG. Long-term follow-up of melatonin treatment in children with ADHD and chronic sleep onset insomnia. J Pineal Res. 2009;47:1–7.

    Article  CAS  PubMed  Google Scholar 

  40. Sallee F, Connor DF, Newcorn JH. A review of the rationale and clinical utilization of α2-adrenoceptor agonists for the treatment of attention-deficit/hyperactivity and related disorders. J Child Adolesc Psychopharmacol. 2013;23:308–19.

    Article  CAS  PubMed  Google Scholar 

  41. Prince JB, Wilens TE, Biederman J, Spencer TJ, Wozniak JR. Clonidine for sleep disturbances associated with attention-deficit hyperactivity disorder: a systemic chart review of 62 cases. J Am Acad Child Adolesc Psychiatry. 1996;35:599–605.

    Article  CAS  PubMed  Google Scholar 

  42. Wilens TE, Biederman J, Spencer T. Clonidine for sleep disturbances associated with attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 1994;33:424–6.

    Article  CAS  PubMed  Google Scholar 

  43. Jain R, Segal S, Kollins SH, Khayrallah M. Clonidine extended-release tablets for pediatric patients with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2011;50:171–9.

    Article  PubMed  Google Scholar 

  44. Blumer JL, Findling RL, Shih WJ, Soubrane C, Reed MD. Controlled clinical trial of zolpidem for the treatment of insomnia associated with attention-deficit/hyperactivity disorder in children 6 to 17 years of age. Pediatrics. 2009;123:e770–6.

    Article  PubMed  Google Scholar 

  45. Sedky K, Carvalho K, Lippmann S. Attention deficit hyperactivity disorder and sleep disordered breathing in children. J Pediatr Biochem. 2013;3:61–7.

    Google Scholar 

  46. Gruber R, Xi T, Frenette S, Robert M, Vannashin P, Carrier J. Sleep disturbances in prepubertal children with attention deficit hyperactivity disorder: a home polysomnography study. Sleep. 2009;32:343–50.

    PubMed  PubMed Central  Google Scholar 

  47. Amiri S, AbdollahiFakhim S, Lotfi A, Bayazian G, Sohrabpour M, Hemmatjoo T. Effect of adenotonsillectomy on ADHD symptoms of children with adenotonsillar hypertrophy and sleep disordered breathing. Int J Pediatr Otorhinolaryngol. 2015;79:1213–7. This study documented the significant effect of adenotonsillectomy on ADHD children with sleep disordered breathing.

    Article  PubMed  Google Scholar 

  48. Mostofsky SH, Cooper KL, Kates WR, Denckla MB, Kaufmann WE. Smaller prefrontal and premotor volumes in boys with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2002;52:785–94.

    Article  PubMed  Google Scholar 

  49. Song SA, Tolisano AM, Cable BB, Camacho M. Neurocognitive outcomes after pediatric adenotonsillectomy for obstructive sleep apnea: a systemic review and meta-analysis. Int J Pediatr Otorhinolaryngol. 2016;83:205–10. This study documented the significant effect of adenotonsillectomy on obstructive sleep apnea, which leads to improved neurocognitive outcomes.

    Article  PubMed  Google Scholar 

  50. Huang YS, Guilleminault C, Li HY, Yang CM, Wu YY, Chen NH. Attention-deficit/hyperactivity disorder with obstructive sleep apnea: a treatment outcome study. Sleep Med. 2007;8:18–30.

    Article  CAS  PubMed  Google Scholar 

  51. Sedky K, Bennett DS, Carvalho KS. Attention deficit hyperactivity disorder and sleep disordered breathing in pediatric populations: a meta-analysis. Sleep Med Rev. 2014;18:349–56.

    Article  PubMed  Google Scholar 

  52. Picchietti MA, Picchietti DL. Advances in pediatric restless legs syndrome: iron, genetics, diagnosis and treatment. Sleep Med. 2010;11:643–51.

    Article  PubMed  Google Scholar 

  53. de Weerd A, Arico I, Silvestri R. Presenting symptoms in pediatric restless legs syndrome patients. J Clin Sleep Med. 2013;9:1077–80.

    PubMed  PubMed Central  Google Scholar 

  54. Oner P, Dirik EB, Taner Y, Caykoylu A, Anlar O. Association between low serum ferritin and restless legs syndrome in patients with attention deficit hyperactivity disorder. Tohoku J Exp Med. 2007;213:269–76.

    Article  CAS  PubMed  Google Scholar 

  55. Paulo Daubian-Nose P, Frank MK, Esteves AM. Sleep disorders: review of the interface between restless legs syndrome and iron metabolism. Sleep Sci. 2014;7:234–7.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Sharon D. Nonpharmacologic management of restless legs syndrome (Willis-Ekbom Disease): myths or science. Sleep Med Clin. 2015;10:263–78.

    Article  PubMed  Google Scholar 

  57. Silber MH, Becker PM, Earley C, Garcia-Borreguero D, Ondo WG, Medical Advisory Board of the Willis-Ekbom Disease Foundation. Willis-Ekbom Disease Foundation revised consensus statement on the management of restless legs syndrome. Mayo Clin Proc. 2013;88:977–86.

    Article  PubMed  Google Scholar 

  58. Rinaldi F, Galbiati A, Marelli S, Ferini Strambi L, Zucconi M. Treatment options in intractable restless legs syndrome/Willis-Ekbom Disease (RLS/WED). Curr Treat Options Neurol. 2016;18:7.

    Article  PubMed  Google Scholar 

  59. Weinstock LB, Walters AS. Restless legs syndrome is associated with irritable bowel syndrome and small intestinal bacterial overgrowth. Sleep Med. 2011;12:610–3.

    Article  PubMed  Google Scholar 

  60. Trenkwalder C, Allen R, Högl B, Paulus W, Winkelmann J. Restless legs syndrome associated with major diseases: a systematic review and new concept. Neurology. 2016;86:1336–43. This article provides the latest updated information regarding restless legs syndrome being as a continuous spectrum with a major genetic contribution and a major comorbid disease of other entities.

    Article  CAS  PubMed  Google Scholar 

  61. Allen RP, Adler CH, Du W, Butcher A, Bregman DB, Earley CJ. Clinical efficacy and safety of IV ferric carboxymaltose (FCM) treatment of RLS: a multi-centred, placebo-controlled preliminary clinical trial. Sleep Med. 2011;12:906–13.

    Article  PubMed  Google Scholar 

  62. Schneider J, Krafft A, Manconi M, Hübner A, Baumann C, Werth E, et al. Open-label study of the efficacy and safety of intravenous ferric carboxymaltose in pregnant women with restless legs syndrome. Sleep Med. 2015;16:1342–7.

    Article  PubMed  Google Scholar 

  63. Grim K, Lee B, Sung AY, Kotagal S. Treatment of childhood-onset restless legs syndrome and periodic limb movement disorder using intravenous iron sucrose. Sleep Med. 2013;14:1100–4.

    Article  PubMed  Google Scholar 

  64. Tilma J, Tilma K, Norregaard O, Ostergaard JR. Early childhood-onset restless legs syndrome: symptoms and effect of oral iron treatment. Acta Paediatr. 2013;105:e221–6.

    Article  Google Scholar 

  65. Konofal E, Lecendreux M, Arnulf I, Mouren MC. Iron deficiency in children with attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med. 2004;158:1113–5.

    Article  PubMed  Google Scholar 

  66. Konofal E, Lecendreux M, Deron J, Marchand M, Cortese S, Zaim M, et al. Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatr Neurol. 2008;38:20–6.

    Article  PubMed  Google Scholar 

  67. England SJ, Picchietti DL, Couvadelli BV, Fisher BC, Siddigui F, Wagner ML, et al. L-Dopa improves restless legs syndrome and periodic limb movements in sleep but not attention-deficit/hyperactivity disorder in a double-blind trial in children. Sleep Med. 2011;12:471–7.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Ferri R, Bruni O, Novelli L, Picchietti MA, Picchietti DL. Time structure of leg movement activity during sleep in attention-deficit/hyperactivity disorder and effects of levodopa. Sleep Med. 2013;14:359–66.

    Article  PubMed  Google Scholar 

  69. Walters AS, Mandelbaum DE, Lewin DS, Kugler S, England SJ, Miller M. Dopaminergic therapy in children with restless legs/periodic limb movements in sleep and ADHD. Dopaminergic Therapy Study Group. Pediatr Neurol. 2000;22:182–6.

    Article  CAS  PubMed  Google Scholar 

  70. Konofal E, Arnulf I, Lecendreux M, Mouren MC. Ropiniole in a child with attention-deficit hyperactivity disorder and restless legs syndrome. Pediatr Neurol. 2005;32:350–1.

    Article  PubMed  Google Scholar 

  71. Gagliano A, Arico I, Calarese T, et al. Restless leg syndrome in ADHD children: levetiracetam as a reasonable therapeutic option. Brain Dev. 2011;33:480–6.

    Article  PubMed  Google Scholar 

  72. Garcia-Borreguero D, Kohnen R, Silber MH, Winkelman JW, Earley CJ, Högl B, et al. The long-term treatment of restless legs syndrome/Willis-Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the international restless legs syndrome study group. Sleep Med. 2013;14:675–84.

    Article  PubMed  Google Scholar 

  73. Cuffe SP, Visser SN, Holbrook JR, Danielson ML, Geryk LL, Wolraich ML, et al. ADHD and psychiatric comorbidity: functional outcomes in a school-based sample of children. J Atten Disord. 2015. doi:10.1177/1087054715613437.

  74. Becker SP, Langberg JM, Evans SW. Sleep problems predict comorbid externalizing behaviors and depression in young adolescents with attention-deficit/hyperactivity disorder. Eur Child Adolesc Psychiatry. 2015;24:897–907. This article highlights the importance of sleep problems as the important predictor of externalizing behavior and depression in ADHD adolescents.

    Article  PubMed  Google Scholar 

  75. Shanahan L, Copeland WE, Angold A, Bondy CL, Costello EJ. Sleep problems predict and are predicted by generalized anxiety/depression and oppositional defiant disorder. J Am Acad Child Adolesc Psychiatry. 2014;53:550–8. This is the first study documenting sleep problems can predict and be predicted by generalized anxiety/depression and oppositional defiant disorder.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Cortese S, Brown TE, Corkum P, Gruber R, O’Brien LM, Stein M, et al. Assessment and management of sleep problems in youths with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2013;52:784–96. This is the expert consensus and meta-analysis regarding the latest assessment and management of sleep problems in youths with ADHD.

    Article  PubMed  Google Scholar 

  77. Papadopoulos N, Sciberras E, Hiscock H, Mulraney M, McGillivray J, Rinehart N. The efficacy of a brief behavioral sleep intervention in school-aged children with ADHD and comorbid autism spectrum disorder. J Atten Disord. 2015. doi:10.1177/1087054714568565.

  78. Sciberras E, Mulraney M, AndersonV, Rapee RM, Nicholson JM, Efron D, et al. Managing anxiety in children with ADHD using cognitive-behavioral therapy: a pilot randomized controlled trial. J Atten Disord. 2015. doi:10.1177/1087054715584054.

  79. Storebø OJ, Ramstad E, Krogh HB, Nilausen TD, Skoog M, Holmskov M, et al. Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD). Cochrane Database Syst Rev. 2015;11:CD009885. This is the latest systemic review and meta-analysis regarding the stimulant effects on children with ADHD.

    PubMed  Google Scholar 

  80. Storebø OJ, Krogh HB, Ramstad E, Moreira-Maia CR, Holmskov M, Skoog M, et al. Methylphenidate for attention-deficit/hyperactivity disorder in children and adolescents: Cochrane systemic review with meta-analyses and trial sequential analyses of randomized clinical trials. BMJ. 2015;351:h5203. This study focusing on whether methylphenidate beneficial or harmful for treatment of ADHD children concludes caution regarding the use of methylphenidate, since it is associated with an increased risk of non-serious adverse events.

  81. Huang YS, Tsai MH. Long-term outcomes with medications for attention-deficit hyperactivity disorder: current status of knowledge. CNS Drugs. 2011;25:539–54.

    Article  PubMed  Google Scholar 

  82. Becker SP, Froehlich TE, Epstein JN. Effects of methylphenidate on sleep functioning in children with attention-deficit/hyperactivity disorder. J Dev Behav Pediatr. 2016;37(5):395–404.

  83. Wang LJ, Chen CK, Huang YS. Gender differences in the behavioral symptoms and neuropsychological performance of patients with attention-deficit/hyperactivity disorder treated with methylphenidate: a two-year follow-up study. J Child Adolesc Psychopharmacol. 2015;25:501–8.

    Article  CAS  PubMed  Google Scholar 

  84. Konofal E, Lecendreux M, Cortese S. Sleep and ADHD. Sleep Med. 2010;11:652–8.

    Article  PubMed  Google Scholar 

  85. Wang LJ, Chen CK, Huang YS. Neurocognitive performance and behavioral symptoms in patients with attention-deficit/hyperactivity disorder during twenty-four months of treatment with methylphenidate. J Child Adolesc Psychopharmacol. 2015;25:246–53.

    Article  PubMed  CAS  Google Scholar 

  86. Lecendreux M, Lavault S, Lopez R, Inocente CO, Konofal E, Cortese S, et al. Attention-deficit/hyperactivity disorder (ADHD) symptoms in pediatric narcolepsy: a cross-sectional study. Sleep. 2015;38:1285–95.

    PubMed  PubMed Central  Google Scholar 

  87. Coghill DR, Banaschewski T, Lecendreux M, Soutullo C, Zuddas A, Adeyi B, et al. Post hoc analyses of the impact of previous medication on the efficacy of lisdexamfetamine dimesylate in the treatment of attention-deficit/hyperactivity disorder in a randomized, controlled trial. Neuropsychiatr Dis Treat. 2014;10:2039–47.

    CAS  PubMed  PubMed Central  Google Scholar 

  88. Simonoff E, Taylor E, Baird G, Bernard S, Chadwick O, Liang H, et al. Randomized controlled double-blind trial of optimal dose methylphenidate in children and adolescents with severe attention deficit hyperactivity disorder and intellectual disability. J Child Psychol Psychiatry. 2013;54:527–35.

    Article  PubMed  Google Scholar 

  89. Gruner JA, Marcy VR, Lin YG, Bozyczko-Coyne D, Marino MJ, Gasior M. The roles of dopamine transport inhibition and dopamine release facilitation in wake enhancement and rebound hypersomnolence induced by dopaminergic agents. Sleep. 2009;32:1425–38.

    PubMed  PubMed Central  Google Scholar 

  90. Roskell NS, Setyawan J, Zimovetz EA, Hodgkins P. Systemic evidence synthesis of treatments for ADHD in children and adolescents: indirect treatment comparisons of lisdexamfetamine with methylphenidate and atomoxetine. Curr Med Res Opin. 2014;30:1673–85.

    Article  CAS  PubMed  Google Scholar 

  91. Coghill DR, Caballero B, Sorooshian S, Civil R. A systemic review of the safety of lisdexamfetamine dimesylate. CNS Drugs. 2014;28:497–511.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. Dittmann RW, Cardo E, Nagy P, Anderson CS, Adeyi B, Caballero B, et al. Treatment response and remission in a double-blind, randomized, head-to-head study of lisdexamfetamine dimesylate and atomoxetine in children and adolescents with attention-deficit hyperactivity disorder. CNS Drugs. 2014;28:1059–69. This study compared the efficacy and side effects of lisdexamfetamine dimesylate and atomoxetine in children with ADHD.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Warrer P, Thomsen PH, Dalsgaard S, Hansen EH, Aagaard L, Wallach Kildemoes H, et al. Switch in therapy from methylphenidate to atomoxetine in children and adolescents with attention-deficit/hyperactivity disorder: an analysis of patient records. J Child Adolesc Psychopharmacol. 2016;26(4):354–61.

  94. Prasad S, Steer C. Switching from neurostimulant therapy to atomoxetine in children and adolescents with attention-deficit hyperactivity disorder: clinical approaches and review of current available evidence. Pediatr Drugs. 2008;10:39–47.

    Article  Google Scholar 

  95. Schwartz S, Correll CU. Efficacy and safety of atomoxetine in children and adolescents with attention-deficit/hyperactivity disorder: results from a comprehensive meta-analysis and metaregression. J Am Acad Child Adolesc Psychiatry. 2014;53:174–87. This study using meta-analysis documented the efficacy and safety of atomoxetine, and concluded it as the alternative choice for children and adolescents with ADHD.

    Article  PubMed  Google Scholar 

  96. Hervas A, Huss M, Johnson M, McNicholas F, van Stralen J, Sreckovic S, et al. Efficacy and safety of extended-release guanfacine hydrochloride in children and adolescents with attention-deficit/hyperactivity disorder: a randomized, controlled, phase III trial. Eur Neuropsychopharmacol. 2014;24:1861–72.

    Article  CAS  PubMed  Google Scholar 

  97. Stein MA, Sikirica V, Weiss MD, Robertson B, Lyne A, Newcorn JH. Does guanfacine extended release impact functional impairment in children with attention-deficit/hyperactivity disorder? Results from a randomized controlled trial. CNS Drugs. 2015;29:953–62. This updated RCT documented guanfacine extended release treatment is associated with reductions in ADHD symptoms, and has tolerable adverse events.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  98. Dittmann RW, Cardo E, Nagy P, Anderson CS, Bloomfield R, Caballero B, et al. Efficacy and safety of lisdexamfetamine dimesylate and atomoxetine in the treatment of attention-deficit/hyperactivity disorder: a head-to-head, randomized, double-blind, phase IIIb study. CNS Drugs. 2013;27:1081–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Daviss WB, Patel NC, Robb AS, McDermott MP, Bukstein OG, Pelham Jr WE, et al. Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis. J Am Acad Child Adolesc Psychiatry. 2008;47:189–98.

    Article  PubMed  Google Scholar 

  100. Ming X, Mulvey M, Mohanty S, Patel V. Safety and efficacy of clonidine and clonidine extended-release in the treatment of children and adolescents with attention deficit and hyperactivity disorders. Adolesc Health Med Ther. 2011;2:105–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Graham J, Banaschewski T, Buitelaar J, Coghill D, Danckaerts M, Dittmann RW, et al. European guidelines on managing adverse effects of medication for ADHD. Eur Child Adolesc Psychiatry. 2011;20:17–37.

    Article  CAS  PubMed  Google Scholar 

  102. Owens JA, Spirito A, McGuinn M. The Children’s Sleep Habits Questionnaire (CSHQ): psychometric properties of a survey instrument for school-aged children. Sleep. 2000;23:1043–51.

    CAS  PubMed  Google Scholar 

  103. Weiss MD, Wasdell MB, Bomben MM, Rea KJ, Freeman RD. Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia. J Am Acad Child Adolesc Psychiatry. 2006;45:512–9.

    Article  PubMed  Google Scholar 

  104. Cortese S, Holtmann M, Banaschewski T, Buitelaar J, Coghill D, Dittmann RW, et al. Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. J Child Psychol Psychiatry. 2013;54:227–46.

    Article  PubMed  Google Scholar 

  105. Hvolby A. Associations of sleep disturbance with ADHD: implications for treatment. Atten Defic Hyperact Disord. 2015;7:1–18.

    Article  PubMed  Google Scholar 

  106. Kim HW, Yoon IY, Cho SC, Kim BN, Chung S, Lee H, et al. The effect of OROS methylphenidate on the sleep of children with attention-deficit/hyperactivity disorder. Int Clin Psychopharmacol. 2010;25:107–15.

    Article  PubMed  Google Scholar 

  107. Wilens TE, Bukstein O, Brams M, Cutler AJ, Childress A, Rugino T, et al. A controlled trial of extended-release guanfacine and psychostimulants for attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2012;51:74–85.

    Article  PubMed  Google Scholar 

  108. Newcorn JH, Stein MA, Childress AC, Youcha S, White C, Enright G, et al. Randomized, double-blind trial of guanfacine extended release in children with attention-deficit/hyperactivity disorder: morning or evening administration. J Am Acad Child Adolesc Psychiatry. 2013;52:921–30.

    Article  PubMed  Google Scholar 

  109. Sallee FR, McGough J, Wigal T, Donahue J, Lyne A, Biederman J, et al. Guanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder: a placebo-controlled trial. J Am Acad Child Adolesc Psychiatry. 2009;48:155–65.

    Article  PubMed  Google Scholar 

  110. Block SL, Kelsey D, Coury D, Lewis D, Quintana H, Sutton V, et al. Once-daily atomoxetine for treating pediatric attention-deficit/hyperactivity disorder: comparison of morning and evening dosing. Clin Pediatr. 2009;48:723–33.

    Article  Google Scholar 

  111. Cortese S, Panei P, Arcieri R, Germinario EA, Capuano A, Margari L, et al. Safety of methylphenidate and atomoxetine in children with attention-deficit/hyperactivity disorder (ADHD): data from the Italian National ADHD Registry. CNS Drugs. 2015;29:865–77.

    Article  CAS  PubMed  Google Scholar 

  112. Shang CY, Pan YL, Lin HY, Huang LW, Gau SS. An open-label, randomized trial of methylphenidate and atomoxetine treatment in children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2015;25:566–73.

    Article  CAS  PubMed  Google Scholar 

  113. Mohammadi MR, Mostafavi SA, Keshavarz SA, Eshraghian MR, Hosseinzadeh P, Hosseinzadeh-Attar MJ, et al. Melatonin effects in methylphenidate treated children with attention deficit hyperactivity disorder: a randomized double blind clinical trial. Iran J Psychiatry. 2012;7:87–92.

    PubMed  PubMed Central  Google Scholar 

  114. Kratochvil CJ, Lake M, Pliszka SR, Walkup JT. Pharmacological management of treatment-induced insomnia in ADHD. J Am Acad Child Adolesc Psychiatry. 2004;44:499–501.

    Article  Google Scholar 

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Acknowledgments

This material is the result of work supported with resources and the use of facilities at the Yunlin Chang Gung Memorial Hospital, Yunlin, Taiwan, Republic of China.

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Authors and Affiliations

  1. Division of Pediatric Neonatology and Hematology/Oncology, Department of Pediatrics, Chang Gung Memorial Hospital, Yunlin, Taiwan

    Ming-Horng Tsai

  2. College of Medicine, Chang Gung University, Taoyuan, Taiwan

    Ming-Horng Tsai, Jen-Fu Hsu & Yu-Shu Huang

  3. Sleep Center and Child Psychiatry Department, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan

    Jen-Fu Hsu & Yu-Shu Huang

  4. Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Jen-Fu Hsu

  5. Department of Child Psychiatry and Sleep Center, Chang Gung Memorial Hospital, 5, Fu-Shing St., Kwei-Shan, Taoyuan, 333, Taiwan

    Yu-Shu Huang

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  1. Ming-Horng Tsai
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Correspondence to Yu-Shu Huang.

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Ming-Horng Tsai, Jen-Fu Hsu, and Yu-Shu Huang declare that they have no conflict of interest.

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This article is part of the Topical Collection on Sleep Disorders

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Tsai, MH., Hsu, JF. & Huang, YS. Sleep Problems in Children with Attention Deficit/Hyperactivity Disorder: Current Status of Knowledge and Appropriate Management. Curr Psychiatry Rep 18, 76 (2016). https://doi.org/10.1007/s11920-016-0711-4

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