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Recent advances in research on successful or healthy aging

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Abstract

This article reports a selective review of biopsychosocial research on successful or healthy aging published in 2005 and 2006. We describe a number of studies that advance the understanding of the definitions, predictors, mechanisms, and potential interventions for successful aging. Successful aging is a multidimensional construct that awaits a standardized definition. A broad array of phenotypes beyond longevity has been examined, including neurocognition, subjective quality of life, and biological age. Considerable progress has been made toward understanding possible mechanisms of successful aging through translational research. Interventions to augment healthy lifestyles have great potential to enhance global healthy aging.

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References and Recommended Reading

  1. Rowe JW, Kahn RL: Human aging: usual and successful. Science 1987, 237:143–149.

    Article  PubMed  CAS  Google Scholar 

  2. Lupien SJ, Wan N: Successful ageing: from cell to self. Philos Trans R Soc Lond B Biol Sci 2004, 359:1413–1426.

    Article  PubMed  CAS  Google Scholar 

  3. Bowling A: The concepts of successful and positive ageing. Fam Pract 1993, 10:449–453.

    Article  PubMed  CAS  Google Scholar 

  4. Peel NM, Bartlett HB, McClure RJ: Healthy ageing how is it defined and measured? Australas J Ageing 2004, 23:115–119.

    Article  Google Scholar 

  5. Depp CA, Jeste DV: Definitions and predictors of successful aging: a comprehensive review of larger quantitative studies. Am J Geriatr Psychiatry 2006, 14:6–20.

    Article  PubMed  Google Scholar 

  6. Karasik D, Demissie S, Cupples LA, Kiel DP: Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures. J Gerontol A Biol Sci Med Sci 2005, 60:574–587.

    PubMed  Google Scholar 

  7. Christensen K, Johnson TE, Vaupel JW: The quest for genetic determinants of human longevity: challenges and insights. Nat Rev Genet 2006, 7:436–448.

    Article  PubMed  CAS  Google Scholar 

  8. Perls TT: The different paths to 100. Am J Clin Nutr 2006, 83:484S–487S.

    PubMed  CAS  Google Scholar 

  9. Motta M, Bennati E, Ferlito L, et al.: Successful aging in centenarians: myths and reality. Arch Gerontol Geriatr 2005, 40:241–251.

    Article  PubMed  CAS  Google Scholar 

  10. Almeida OP, Norman P, Hankey G, et al.: Successful mental health aging: results from a longitudinal study of older Australian men. Am J Geriatr Psychiatry 2006, 14:27–35.

    Article  PubMed  Google Scholar 

  11. Ostbye T, Krause KM, Norton MC, et al.: Ten dimensions of health and their relationships with overall self-reported health and survival in a predominately religiously active elderly population: the cache county memory study. J Am Geriatr Soc 2006, 54:199–209.

    Article  PubMed  Google Scholar 

  12. Bowling A, Dieppe P: What is successful ageing and who should define it? BMJ 2005, 331:1548–1551.

    Article  PubMed  Google Scholar 

  13. Montross LP, Depp C, Daly J, et al.: Correlates of self-rated successful aging among community-dwelling older adults. Am J Geriatr Psychiatry 2006, 14:43–51.

    Article  PubMed  Google Scholar 

  14. Eiseman B: When blue turns gray: postwarranty performance. Am J Geriatr Psychiatry 2006, 14:21–26.

    Article  PubMed  Google Scholar 

  15. Matsubayashi K, Ishine M, Wada T, et al.: Older adults’ views of “successful aging”: comparison of older Japanese and Americans. J Am Geriatr Soc 2006, 54:184–187.

    Article  PubMed  Google Scholar 

  16. Aviv A, Levy D, Mangel M: Growth, telomere dynamics and successful and unsuccessful human aging. Mech Ageing Dev 2003, 124:829–837.

    Article  PubMed  CAS  Google Scholar 

  17. Stewart SA, Weinberg RA: Telomeres: cancer to human aging. Annu Rev Cell Dev Biol 2006, 22:531–557.

    Article  PubMed  CAS  Google Scholar 

  18. Klemera P, Doubal S: A new approach to the concept and computation of biological age. Mech Ageing Dev 2006, 127:240–248.

    Article  PubMed  Google Scholar 

  19. Kalichman L, Kobyliansky E, Seibel MJ, et al.: Repeated measurement study of hand osteoarthritis in an apparently healthy Caucasian population. Am J Hum Biol 2005, 17:611–621.

    Article  PubMed  Google Scholar 

  20. Peel NM, McClure RJ, Bartlett HP: Behavioral determinants of healthy aging. Am J Prev Med 2005, 28:298–304.

    Article  PubMed  Google Scholar 

  21. Chiuve SE, McCullough ML, Sacks FM, et al.: Healthy lifestyle factors in the primary prevention of coronary heart disease among men: benefits among users and nonusers of lipid-lowering and antihypertensive medications. Circulation 2006, 114:160–167.

    Article  PubMed  Google Scholar 

  22. Kurth T, Moore SC, Gaziano JM, et al.: Healthy lifestyle and the risk of stroke in women. Arch Intern Med 2006, 166:1403–1409.

    Article  PubMed  Google Scholar 

  23. Stampfer MJ, Hu FB, Manson JE, et al.: Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med 2000, 343:16–22.

    Article  PubMed  CAS  Google Scholar 

  24. Zubenko GS, Hughes HB, 3rd, Zubenko WN, et al.: Genome survey for loci that influence successful aging: results at 10-cM resolution. Am J Geriatr Psychiatry 2006. [Epub ahead of print].

  25. Marchegiani F, Marra M, Spazzafumo L, et al.: Paraoxonase activity and genotype predispose to successful aging. J Gerontol A Biol Sci Med Sci 2006, 61:541–546.

    PubMed  Google Scholar 

  26. Hu P, Bretsky P, Crimmins EM, et al.: Association between serum beta-carotene levels and decline of cognitive function in high-functioning older persons with or without apolipoprotein E 4 alleles: MacArthur studies of successful aging. J Gerontol A Biol Sci Med Sci 2006, 61:616–620.

    PubMed  Google Scholar 

  27. Seeman TE, Huang MH, Bretsky P, et al.: Education and APOE-e4 in longitudinal cognitive decline: MacArthur studies of successful aging. J Gerontol B Psychol Sci Soc Sci 2005, 60:P74–P83.

    PubMed  Google Scholar 

  28. Mattson MP, Magnus T: Ageing and neuronal vulnerability. Nat Rev Neurosci 2006, 7:278–294.

    Article  PubMed  CAS  Google Scholar 

  29. Karlamangla AS, Singer BH, McEwen BS, et al.: Allostatic load as a predictor of functional decline. MacArthur studies of successful aging. J Clin Epidemiol 2002, 55:696–710.

    Article  PubMed  Google Scholar 

  30. Karlamangla AS, Singer BH, Seeman TE: Reduction in allostatic load in older adults is associated with lower all-cause mortality risk: MacArthur studies of successful aging. Psychosom Med 2006, 68:500–507.

    Article  PubMed  Google Scholar 

  31. Daselaar SM, Fleck MS, Dobbins IG, et al.: Effects of healthy aging on hippocampal and rhinal memory functions: an event-related fMRI study. Cereb Cortex 2006. [Epub ahead of print].

  32. Velanova K, Lustig C, Jacoby LL, Buckner RL: Evidence for frontally mediated controlled processing differences in older adults. Cereb Cortex 2006. [Epub ahead of print].

  33. Lee HK, Min SS, Gallagher M, et al.: NMDA receptor-independent long-term depression correlates with successful aging in rats. Nat Neurosci 2005, 8:1657–1659.

    Article  PubMed  CAS  Google Scholar 

  34. Perls TT: Anti-aging quackery: human growth hormone and tricks of the trade—more dangerous than ever. J Gerontol A Biol Sci Med Sci 2004, 59:682–691.

    PubMed  Google Scholar 

  35. Kramer A, Erickson KI, Colcombe SJ: Exercise, cognition and the aging brain. J Appl Physiol 2006, 101:1237–1242.

    Article  PubMed  Google Scholar 

  36. Heyn P, Abreu BC, Ottenbacher KJ: The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil 2004, 85:1694–1704.

    Article  PubMed  Google Scholar 

  37. Olshansky SJ, Passaro DJ, Hershow RC, et al.: A potential decline in life expectancy in the United States in the 21st century. N Engl J Med 2005, 352:1138–1145.

    Article  PubMed  CAS  Google Scholar 

  38. Sitzer DI, Twamley EW, Jeste DV: Cognitive training in Alzheimer’s disease: a meta-analysis of the literature. Acta Psychiatr Scand 2006, 114:75–90.

    Article  PubMed  CAS  Google Scholar 

  39. Mahncke HW, Connor BB, Appelman J, et al.: Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study. Proc Natl Acad Sci U S A 2006, 103:12523–12528.

    Article  PubMed  CAS  Google Scholar 

  40. Menec VH: The relation between everyday activities and successful aging: a 6-year longitudinal study. J Gerontol B Psychol Sci Soc Sci 2003, 58:S74–S82.

    PubMed  Google Scholar 

  41. Loucks EB, Berkman LF, Gruenewald TL, et al.: Relation of social integration to inflammatory marker concentrations in men and women 70 to 79 years. Am J Cardiol 2006, 97:1010–1016.

    Article  PubMed  CAS  Google Scholar 

  42. Stampfer MJ, Kang JH, Chen J, et al.: Effects of moderate alcohol consumption on cognitive function in women. N Engl J Med 2005, 352:245–253.

    Article  PubMed  CAS  Google Scholar 

  43. Lang JE, Anderson L, LoGerfo J, et al.: The Prevention Research Centers Healthy Aging Research Network. Prev Chronic Dis 2006, 3:A17.

    PubMed  Google Scholar 

  44. Rejeski WJ, Fielding RA, Blair SN, et al.: The lifestyle interventions and independence for elders (LIFE) pilot study: design and methods. Contemp Clin Trials 2005, 26:141–154.

    Article  PubMed  Google Scholar 

  45. Perls TT, Reisman NR, Olshansky SJ: Provision or distribution of growth hormone for “antiaging”: clinical and legal issues. JAMA 2005, 294:2086–2090.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Colin A. Depp PhD.

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Depp, C.A., Glatt, S.J. & Jeste, D.V. Recent advances in research on successful or healthy aging. Curr Psychiatry Rep 9, 7–13 (2007). https://doi.org/10.1007/s11920-007-0003-0

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