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New developments in the neurobiology of borderline personality disorder

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Abstract

Within the past several years, research on the clinical phenomena and neurobiology of borderline personality disorder has increased substantially. Borderline personality disorder is currently best thought of in terms of dimensions rather than as a categorical disorder. This article reviews the most recent findings on two of the core dimensions— affective dysregulation and impulsivity. Most of the neuropsychologic, physiologic, endocrinologic, and neuroimaging data support the theory that a dual brain pathology, affecting prefrontal and limbic circuits, may underlie this hyperarousal-dyscontrol syndrome.

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Authors and Affiliations

  1. Central Institute of Mental Health Mannheim, University of Heidelberg, J 5, 68159, Mannheim, Germany

    Martin Bohus MD

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  1. Martin Bohus MD
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  2. Christian Schmahl MD
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  3. Klaus Lieb MD
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Bohus, M., Schmahl, C. & Lieb, K. New developments in the neurobiology of borderline personality disorder. Curr Psychiatry Rep 6, 43–50 (2004). https://doi.org/10.1007/s11920-004-0038-4

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